Xenograft News and Research

RSS

Xenograft are the cells of one species transplanted to another species.

Insights gained from genetically modified pig heart transplantation

Researchers described a genetically engineered pig cardiac xenotransplantation in a 57-year-old male patient.

3 Jul 2023

Analyzing the role of LP-284 Hodgkin's lymphoma models and in DNA damage repair

A new research paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, "LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair."

13 Jun 2023

Research opens door to new, more efficient drug combinations for acute myeloid leukemia

Acute myeloid leukemia (AML) is a very aggressive disease in which cells proliferate abnormally, invading the bone marrow and interfering with normal blood cell production. It is the most common acute leukemia in adults with the worst prognosis.

5 Jun 2023

Study shows impacts of ASO-based MALAT1-inhibition on MAPK-pathway gene regulation in melanoma

A new research paper was published in Oncotarget's Volume 14 on May 26, 2023, entitled, "Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment."

30 May 2023

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Research unveils the significance of uridine as a metabolic fuel in pancreatic ductal adenocarcinoma (PDA) cells under glucose-deprived conditions. Uridine utilization, mediated by uridine phosphorylase 1 (UPP1), supports redox balance, survival, and proliferation in PDA, highlighting its potential as a novel therapeutic target in the treatment of this resistant cancer.

23 May 2023

New liquid biopsy tool shows 30% increased sensitivity in detecting ctDNA

Pancreatic cancer is the seventh leading cause of cancer death worldwide and despite the increasing incidence of this disease, effective treatments are lacking and prognosis for patients with this tumor type remains poor, with approximately 70% of patients dying within one year of diagnosis.

16 May 2023

High-grade gliomas remodel neural circuits: promoting tumor progression and impaired cognition

Researchers investigated whether functional connectivity between glioblastoma and the brain affected neural circuits.

9 May 2023

New approach to CAR T-cell therapy shows promise against small cell lung cancer in preclinical study

A new approach to chimeric antigen receptor T-cell (CAR T) therapy has shown great promise against small cell lung cancer (SCLC) in a preclinical study.

25 Apr 2023

Study reveals DCAF1 protein's role in colon cancer development through EZH2 phosphorylation

A recent study reveals that DCAF1 is overexpressed and phosphorylates EZH2 in colon cancer cells.

18 Apr 2023

Johns Hopkins Medicine surgeons to receive $21.4 million to advance xenotransplantation research

As part of the worldwide effort to facilitate a research and clinical pathway toward successful xenotransplantation -; the transplantation of living cells, tissues and organs from one species to another -; two Johns Hopkins Medicine surgeons, Kazuhiko Yamada, M.D., Ph.D., and Andrew Cameron, M.D., Ph.D., will receive a total of $21.4 million in funding over the next two years under two sponsored research agreements with biotechnology company United Therapeutics Corporation.

29 Mar 2023

New imaging method could help make better decisions on personalized cancer treatment

Decisions on cancer treatment could become better tailored to individual patients with the adoption of a new imaging method being developed by University of Michigan researchers that maps the chemical makeup of a patient’s tumor.

1 Mar 2023

New funding to accelerate development of potential anti-cancer compound into the clinic

For the past few decades, Dr. Iwao Ojima has been working in his Stony Brook University Department of Chemistry Laboratory and through the Institute of Chemical Biology & Drug Discovery (ICB&DD) to develop next-generation anti-cancer agents.

28 Feb 2023

Ants show the potential to become a fast, efficient, inexpensive, and non-invasive tool for the detection of human tumors

Researchers demonstrated the use of ants as olfactory bio-detectors of human tumors.

31 Jan 2023

Study elucidates the potential role of STRO-001 in B-cell non-Hodgkin lymphoma

A new research paper was published in Oncotarget's Volume 14 on January 12, 2023, entitled, "Targeting CD74 in B-cell non-Hodgkin lymphoma with the antibody-drug conjugate STRO-001."

18 Jan 2023

Study uncovers a new role for Slit2 signaling in stimulating Ewing sarcoma growth

A new research paper was published in Genes & Cancer on December 14, 2022, entitled, "Slit2 signaling stimulates Ewing sarcoma growth."

13 Jan 2023

New cooling strategy could prevent the growth of glioblastoma

Cooling brain tumor cells to stop them from dividing without killing healthy cells extended the survival of glioblastoma (GBM) animal models dramatically in a study led by a UT Southwestern resident.

12 Jan 2023

Simple method increases the efficacy of T cell therapy by cytokine conjugation

The recent years have seen a wave of adoptive cell therapies (ACTs), a type of immunotherapy in which T cells (T cell transfer therapy) and other immune cells are obtained from patients, activated and multiplied outside the body, and infused in larger numbers back into the blood circulation to help fight cancers.

11 Jan 2023