binding affinity News and Research

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Triple drug regimen proven effective against non-structural protein-1 of SARS-CoV-2

Researchers evaluated the synergistic activity of drugs acting against non-structural protein 1 of SARS-CoV-2 to decrease the viral infectivity.

2 Mar 2022

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

Researchers used deep mutational scans to measure the effect of each amino-acid mutation in the receptor-binding domain of SARS-CoV-2 Wuhan-Hu-1, Alpha, Beta, Delta, and Eta variants.

1 Mar 2022

Biophysical fitness profile of SARS-CoV-2 Delta variant

In a recent study posted to the bioRxiv* preprint server, researchers investigated the biophysical fitness landscape of the receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant.

1 Mar 2022

Research explains how SARS-CoV-2 variants evade some antibodies

A recent study published in the iScience Journal assessed the influence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on coronavirus disease 2019 (COVID-19) infectivity and viral neutralization.

22 Feb 2022

Molecular characteristics of SARS-CoV-2 variants enabling antibody escape

A new review paper published in PLoS Pathogens discusses the new variants and the structural mechanism underlying antibody-mediated neutralization as well as mutational antibody escape.

21 Feb 2022

Inhalable antibody fragments offer broad protection from SARS-CoV-2 variants

A new study describes a potential new approach to treating COVID-19 in the form of single-chain fragment variable (scFv) antibodies.

20 Feb 2022

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Researchers investigated the connecting link between viral genetic variability and clinical heterogeneity of COVID-19 by analyzing the effect of several missense mutations on the ACE2 receptor coding sequence.

18 Feb 2022

Study explores the high viral loads of SARS-CoV-2 Delta and Alpha variants

In a new study, scientists evaluated the cycle threshold values from 1,297 COVID-19-positive saliva samples obtained at a testing lab in the USA.

17 Feb 2022

A novel consensus-based computational pipeline that reliably predicts hACE2-RBD binding affinity

Researchers developed a novel computational model to predict the binding affinity between the hACE2 receptor and the RBD of S protein of SARS-CoV-2.

17 Feb 2022

Children with severe COVID-19 show low mucosal neutralizing activity against SARS-CoV-2

A new study examines neutralizing responses to the ancestral variant of SARS-CoV-2, as well as against later variants of concern.

16 Feb 2022

Study explores how the electrostatic charge of the SARS-CoV-2 spike protein has changed over time

In a new study, researchers examined the effect of electrostatic changes on the ability of the SARS-CoV-2 Omicron variant to escape immunity.

16 Feb 2022

Antiviral activity assessment of remdesivir against 10 current and former SARS-CoV-2 variant clinical isolates

A new study published demonstrated the in vitro potencies of RDV and GS-441524 through PRA, and nucleoprotein ELISA against SARS-CoV-2 and other VOC/VOIs isolates with specific substitutions in Nsp12.

15 Feb 2022

Study describes a β-CoV spike protein target for protective antibodies that may facilitate pan-β-CoV vaccine development

In a recent study published in Science Translational Medicine, researchers characterized a human antibody targeting betacoronaviruses (β-CoVs).

14 Feb 2022

Rapid generation and evaluation of an mRNA vaccine candidate specific to Omicron

A recent study demonstrated the development of a potential SARS-CoV-2 Omicron variant-specific mRNA vaccine candidate.

10 Feb 2022

The effect of Omicron mutations at the fundamental atomic scale level

The present study provided interesting insights into the interactions of AAs at the interface between SARS-CoV-2 spike and human ACE2 receptors.

10 Feb 2022

Investigating taraxerol as a protease inhibitor against SARS-CoV-2

In a recent study posted to the Research Square preprint* server, a team of researchers investigated the toxicity and absorption, distribution, metabolism, and excretion (ADME) characteristics of a potent herbal drug, taraxerol, in the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The paper is under consideration for publication in the Structural Chemistry journal.

7 Feb 2022

binding affinity News and Research

Triple drug regimen proven effective against non-structural protein-1 of SARS-CoV-2

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

Biophysical fitness profile of SARS-CoV-2 Delta variant

Research explains how SARS-CoV-2 variants evade some antibodies

Molecular characteristics of SARS-CoV-2 variants enabling antibody escape

Inhalable antibody fragments offer broad protection from SARS-CoV-2 variants

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Study explores the high viral loads of SARS-CoV-2 Delta and Alpha variants

A novel consensus-based computational pipeline that reliably predicts hACE2-RBD binding affinity

Children with severe COVID-19 show low mucosal neutralizing activity against SARS-CoV-2

Study explores how the electrostatic charge of the SARS-CoV-2 spike protein has changed over time

Antiviral activity assessment of remdesivir against 10 current and former SARS-CoV-2 variant clinical isolates

Study describes a β-CoV spike protein target for protective antibodies that may facilitate pan-β-CoV vaccine development

Rapid generation and evaluation of an mRNA vaccine candidate specific to Omicron

The effect of Omicron mutations at the fundamental atomic scale level

Investigating taraxerol as a protease inhibitor against SARS-CoV-2

Evolutionary history of ACE2 binding across a diverse range of sarbecoviruses and ACE2 orthologs

Booster vaccines found to augment T-cell responses to SARS-CoV-2 Omicron

Predicting immunity evasion of SARS-CoV-2 Omicron variant of concern

Molecular simulations provide insight into SARS-CoV-2 variant RBD interactions with ACE2 and mAbs

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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