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Curcumin boosts brain delivery of HIV drug, curbing inflammation and oxidative stress

Study shows curcumin enhances antiretroviral delivery and reduces inflammation and oxidative stress in HIV, offering potential improvements in treating HIV-associated neurocognitive disorders.

16 Nov 2023

Senolytics show promise in combating brain aging and COVID-19 neuropathology

Study reveals that senolytics can reduce aging in human brain organoids and mitigate COVID-19 neuropathology, suggesting their potential as a therapeutic strategy against brain aging and coronavirus-related neurological complications.

15 Nov 2023

Cancer stem cells induce macrophage aging, creating conditions for tumor formation

Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.

14 Nov 2023

Non-invasive device detects Alzheimer's and Parkinson's biomarkers with high accuracy

An international team of researchers has developed a handheld, non-invasive device that can detect biomarkers for Alzheimer's and Parkinson's Diseases.

13 Nov 2023

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

A prospective path for allogeneic cellular immunotherapies.

13 Nov 2023

Crown Bioscience launches large-scale organoid panel screening platform for accelerated preclinical oncology drug discovery

Crown Bioscience, a global contract research organization (CRO) and JSR Life Sciences company, today announced the launch of its ground-breaking service offering, OrganoidXploreTM.

13 Nov 2023

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

In this study, researchers harnessed crowdsourcing and open science to develop new antivirals against SARS-CoV-2, focusing on its main protease, Mpro. Their approach led to the discovery of potent compounds, including one with high efficacy in cell lines and cross-reactivity against various COVID-19 variants, demonstrating the potential of collaborative and transparent drug discovery in tackling global health crises.

12 Nov 2023

Brazzein and monellin: Safe alternatives to sugar, new research confirms

Toxicity assessments of monellin and brazzein.

10 Nov 2023

Blooming health: Unfolding the petal-perfect virtues of edible flowers

A comprehensive review of the nutritional and therapeutic benefits of edible flowers highlights their role in health, food security, and environmental sustainability. This study provides insight into the nutritional content of flowers, their potential health benefits due to bioactive compounds, and innovative sustainable uses like phytoremediation and natural dyes.

9 Nov 2023

Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

In this groundbreaking study, researchers developed a mucosal adenoviral-vector vaccine, ChAd-SARS-CoV-2-S, which demonstrated sustained and robust immunity against a challenging Omicron variant in nonhuman primates, indicating a promising direction for durable COVID-19 protection strategies. Unlike traditional intramuscular vaccines, this mucosal vaccine elicited a comprehensive immune response, potentially paving the way for more effective and long-lasting COVID-19 vaccines.

9 Nov 2023

Preclinical discovery could point the way toward better treatments for type 2 diabetes

A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes, according to a new study by Weill Cornell Medicine investigators.

9 Nov 2023

Researchers identify a novel bacterial protein that can keep human cells healthy

Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden.

9 Nov 2023

New device could keep implantable "living pharmacy" cells alive for months

In 2021, a Northwestern University-led research team received a Defense Advanced Research Projects Agency (DARPA) contract worth up to $33 million to develop an implantable "living pharmacy" to control the human body's sleep/wake cycles.

9 Nov 2023

Cannabis and derivatives show promise in reducing weight and waist circumference, with nuanced effects on body fat

The study in the International Journal of Obesity reports that cannabis and its derivatives may influence weight and waist circumference, with different effects on body fat, suggesting potential as a therapeutic aid in obesity management.

8 Nov 2023

New antifungal molecule shows promise in combatting fungal infections without toxicity

A new antifungal molecule, devised by tweaking the structure of prominent antifungal drug Amphotericin B, has the potential to harness the drug's power against fungal infections while doing away with its toxicity, researchers at the University of Illinois Urbana-Champaign and collaborators at the University of Wisconsin-Madison report in the journal Nature.

8 Nov 2023

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

Researchers at the Centre for Genomic Regulation and Vall d'Hebron Institute of Oncology have shown that the simultaneous inhibition of two different proteins may represent a new strategy for tackling triple-negative breast cancer, the most aggressive and drug-resistant form of breast cancer.

8 Nov 2023

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

Researchers discover the BA.2.86 Omicron lineage with higher transmission potential than current dominant strains, yet show that existing antivirals remain effective. Despite its higher infectivity, BA.2.86 exhibits lower pathogenicity in hamsters, indicating decreased replication capacity may lead to less severe infections.

7 Nov 2023

Scientists develop tissue adhesive gelatin hydrogels to speed up wound healing, prevent infections

Open wounds, whether caused by accidents or from medical procedures like surgery, require proper management to speed up healing and prevent infections.

6 Nov 2023

Marijuana-like compound shows promise as new treatment for skin lupus

A marijuana-like compound holds out promise as a new treatment for a severe autoimmune skin disease called skin lupus, according to a study published recently by a multicenter team including researchers at the George Washington University.

2 Nov 2023

Seaweed symbionts reveal treasure trove of potential drug compounds

Marine macroalgae-associated Bacillota reveal a trove of bioactive compounds with potential pharmacological benefits, from antibacterial to anticancer properties. This comprehensive review illuminates the promising yet underexplored therapeutic applications of these marine microorganisms.

1 Nov 2023

in vitro News and Research

Curcumin boosts brain delivery of HIV drug, curbing inflammation and oxidative stress

Senolytics show promise in combating brain aging and COVID-19 neuropathology

Cancer stem cells induce macrophage aging, creating conditions for tumor formation

Non-invasive device detects Alzheimer's and Parkinson's biomarkers with high accuracy

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

Crown Bioscience launches large-scale organoid panel screening platform for accelerated preclinical oncology drug discovery

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

Brazzein and monellin: Safe alternatives to sugar, new research confirms

Blooming health: Unfolding the petal-perfect virtues of edible flowers

Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

Preclinical discovery could point the way toward better treatments for type 2 diabetes

Researchers identify a novel bacterial protein that can keep human cells healthy

New device could keep implantable "living pharmacy" cells alive for months

Cannabis and derivatives show promise in reducing weight and waist circumference, with nuanced effects on body fat

New antifungal molecule shows promise in combatting fungal infections without toxicity

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

Scientists develop tissue adhesive gelatin hydrogels to speed up wound healing, prevent infections

Marijuana-like compound shows promise as new treatment for skin lupus

Seaweed symbionts reveal treasure trove of potential drug compounds

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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