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Treatment with rheumatoid arthritis drug saved transplanted kidney and achieved remission

A drug approved for the treatment of rheumatoid arthritis may also turn out to be the first targeted therapy for one of the most common forms of kidney disease, a condition that almost inevitably leads to kidney failure.

11 Nov 2013

Levels of BPA in components of dialysis machines may be toxic to patients' immune cells

Levels of bisphenol A (BPA) in components of dialysis machines may be toxic to the immune cells circulating in kidney failure patients' blood, according to a study that will be presented at ASN Kidney Week 2013 November 5-10 at the Georgia World Congress Center in Atlanta, GA.

8 Nov 2013

Study reveals that lower dose of BPA contributes to large range of health problems in humans

Bisphenol A (BPA) is a known endocrine disruptor that hijacks the normal responses of hormones. Yet, traditional toxicology studies indicate that only very high doses of this chemical affect exposed animals-doses as high as 50 mg/kg/day.

8 Nov 2013

Researchers identify new class of anti-inflammatory drugs may be used to treat IBD

Researchers in UCD Conway Institute and Systems Biology Ireland have identified a way that a new class of anti-inflammatory drugs may be used to treat inflammatory bowel disease (IBD).

7 Nov 2013

Researchers discover relationship between TGFb signalling pathways and CXCR4 in HCC

Researchers from the Biological clues of the invasive and metastatic phenotype group of the Bellvitge Biomedical Research Institute (IDIBELL) led by Isabel Fabregat have discovered the relationship between the TGFb signalling pathways and CXCR4 in hepatocellular carcinoma (HCC) .

7 Nov 2013

One Lambda gets CE mark approval in Europe for C1qScreen assay

One Lambda Inc., part of Thermo Fisher Scientific and a leading producer of in vitro diagnostic products for the human leukocyte antigen transplant community, has received CE mark approval in Europe for its C1qScreen assay.

6 Nov 2013

Bruker to hold NMR webinar in late November

One of the world's leading analytical instrumentation companies is presenting an educational webinar on nuclear magnetic resonance (NMR) later this month.

From Bruker BioSpin - NMR, EPR and Imaging 5 Nov 2013

Oncology drug development services: an interview with Dr. Jean-Pierre Wery, President of Crown Bioscience, Inc.

Crown serves pharmaceutical companies and biotech companies. We have two areas of focus: oncology and metabolic diseases. In the oncology space we focus on pre-clinical services. Essentially, we have all the tools to help our customers move from target discovery, target validation, to a clinical candidate.

31 Oct 2013

Researchers receive grant to develop new device that identifies healthy sperm cells for IVF

The World Health Organization estimates more than 70 million couples worldwide are unable to conceive each year, with close to a third of those cases attributable solely to issues with male fertility-including low sperm count and low sperm motility (a limited ability to swim).

31 Oct 2013

New understanding of sperm capacitation may improve IVF success rates

Two new papers from reproductive biologists at the University of Massachusetts Amherst, with international partners, report advances in understanding the basic processes of sperm capacitation that may one day improve success rates of in vitro fertilization (IVF) by providing a shortcut to bypass problems, and may eventually lead to a male contraceptive.

29 Oct 2013

Current drugs may harbor small-cell lung cancer promise

Scientists have identified several existing non-oncology drug classes that may have potential as a treatment for small-cell lung cancer, especially for patients with chemoresistant and metastatic disease.

28 Oct 2013

Whitehead Institute scientists identify novel Parkinson's disease drug target

Using a discovery platform whose components range from yeast cells to human stem cells, Whitehead Institute scientists have identified a novel Parkinson's disease drug target and a compound capable of repairing neurons derived from Parkinson's patients.

25 Oct 2013

Diffregen awarded SBIR Phase 1 grant to advance Angiocidin towards human clinical trials

Diffregen LLC, a Temple University startup company, has been awarded a small business innovation research Phase 1 grant by the National Cancer Institute to advance Angiocidin, a university-created therapeutic to treat acute myeloid leukemia, to the doorstep of human clinical trials.

24 Oct 2013

Functional biomarker could help guide treatment of patients with BRAF-mutant melanomas

A functional biomarker that can predict whether BRAF-mutant melanomas respond to drugs targeting BRAF could help guide the treatment of patients with these cancers, according to results presented here at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19 - 23.

23 Oct 2013

Verastem presents positive results from VS-6063 clinical and preclinical studies at 2013 AACR-NCI-EORTC meeting

Verastem, Inc., focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced positive results from the Phase 1 portion of its Phase 1/1b study of defactinib (VS-6063) in combination with paclitaxel in patients with ovarian cancer that were presented at the 2013 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston.

21 Oct 2013

Wnt5A signaling pathway helps researchers determine who may respond to BRAF inhibitors

One of the challenges of understanding cancer is trying to determine the mechanisms that drive metastasis, or the process by which tumor cells are able to spread throughout the body.

19 Oct 2013

CIRM President Steps Down After Six Years

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18 Oct 2013

Stem Cell Therapeutics Nabs Sirpa Protein-Targeting Mabs

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18 Oct 2013

Study finds increase in use of donor eggs for in vitro fertilization

Between 2000 and 2010 in the United States the number of donor eggs used for in vitro fertilization increased, and outcomes for births from those donor eggs improved, according to a study published by JAMA. The study is being released early online to coincide with its presentation at the American Society for Reproductive Medicine and the International Federation of Fertility Societies joint annual meeting.

18 Oct 2013

Stem Cell Therapeutics Nabs Sirpa Protein-Targeting Mabs

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17 Oct 2013

in vitro News and Research

Treatment with rheumatoid arthritis drug saved transplanted kidney and achieved remission

Levels of BPA in components of dialysis machines may be toxic to patients' immune cells

Study reveals that lower dose of BPA contributes to large range of health problems in humans

Researchers identify new class of anti-inflammatory drugs may be used to treat IBD

Researchers discover relationship between TGFb signalling pathways and CXCR4 in HCC

One Lambda gets CE mark approval in Europe for C1qScreen assay

Bruker to hold NMR webinar in late November

Oncology drug development services: an interview with Dr. Jean-Pierre Wery, President of Crown Bioscience, Inc.

Researchers receive grant to develop new device that identifies healthy sperm cells for IVF

New understanding of sperm capacitation may improve IVF success rates

Current drugs may harbor small-cell lung cancer promise

Whitehead Institute scientists identify novel Parkinson's disease drug target

Diffregen awarded SBIR Phase 1 grant to advance Angiocidin towards human clinical trials

Functional biomarker could help guide treatment of patients with BRAF-mutant melanomas

Verastem presents positive results from VS-6063 clinical and preclinical studies at 2013 AACR-NCI-EORTC meeting

Wnt5A signaling pathway helps researchers determine who may respond to BRAF inhibitors

CIRM President Steps Down After Six Years

Stem Cell Therapeutics Nabs Sirpa Protein-Targeting Mabs

Study finds increase in use of donor eggs for in vitro fertilization

Stem Cell Therapeutics Nabs Sirpa Protein-Targeting Mabs

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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