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Cordyceps sinensis shown to alleviate idiopathic pulmonary fibrosis in mice

A recent study from China has reported that Cordyceps sinensis (CS), a traditional Chinese medicinal fungus, can ameliorate idiopathic pulmonary fibrosis (IPF) in mice by inhibiting mitochondrion-mediated oxidative stress.

25 Jul 2024

Novel antisense therapy targets α-synuclein pathologies in neurodegenerative diseases

TMDU researchers demonstrate proof of concept of antisense nucleic acid therapy to prevent the spread of α-synuclein pathologies in synucleinopathies.

25 Jul 2024

Oligodendrocytes identified as key amyloid β producers in Alzheimer's disease

Researchers discovered that oligodendrocytes, not just neurons, produce amyloid β in Alzheimer's disease, and suppressing their activity improves disease pathology. This finding suggests new therapeutic targets for Alzheimer's treatment.

24 Jul 2024

Breakthrough in acute myeloid leukemia treatment targets stem cells

Acute myeloid leukemia is one of the deadliest cancers. Leukemic stem cells responsible for the disease are highly resistant to treatment.

24 Jul 2024

Study unveils key mechanisms behind colorectal cancer metastasis to the liver

In cases where cancer is fatal, nine out of ten times the culprit is metastasis.

24 Jul 2024

Creating the first genetically susceptible mice for late-onset Alzheimer's

Mice don't get Alzheimer's-;and while that's good news for mice, it's a big problem for biomedical researchers seeking to understand the disease and test new treatments.

24 Jul 2024

Oral-gut axis: How mouth bacteria impact your overall health

A recent review in Nature Reviews Microbiology highlights how oral and gut microbiomes interact, impacting overall human health. Oral microorganisms can enter the gut, contributing to dysbiosis and various diseases, necessitating further research on these complex interactions.

24 Jul 2024

New strategy for mRNA nanocarriers using triphenyl phosphonium

Among the vastly different ways of tackling a disease, controlling the genetic expression of cells is undoubtedly one of the most powerful. Over the past few decades, scientists have come up with dozens of innovative strategies that involve using messenger RNA (mRNA) to 'force' cells to build specific proteins. These mRNA-based therapies have recently gained prominence as vaccines against infectious diseases like COVID-19. Additionally, they hold significant potential for treating cancer and genetic disorders.

23 Jul 2024

Research may pave the way for systemic targeted therapy for patients with pseudomyxoma peritonei

Published in Clinical Cancer Research, results of a preclinical study led by investigators of the Vall d'Hebron Institute of Oncology's (VHIO) Stem Cells and Cancer Group, headed by Héctor G. Palmer, pave the way for systemic targeted therapy in patients with pseudomyxoma peritonei, a rare form of cancer with very few therapeutic options available.

19 Jul 2024

Hydrogel implant technology offers new hope for women seeking reversible sterilization and endometriosis treatment

Hydrogel implants for reversible fallopian tube occlusion, providing contraception and preventing endometriosis.

19 Jul 2024

Distinct signaling pathway drives the transformation of epithelial cells into aggressive tumors

A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells.

18 Jul 2024

Novel neutrophil-engineered nanovesicles could transform infectious wound treatment

A recent study has developed nanovesicles (NVs) from activated neutrophils, showcasing their ability to perform molecular debridement and accelerate healing in infectious wounds.

18 Jul 2024

Researchers find a special group of "first responder" cells crucial for triggering blood sugar response

How does our body control blood sugar so precisely? An international research team led by scientists from the Paul Langerhans Institute Dresden (PLID) of the German Center for Diabetes Research brought us a step closer to the answer.

17 Jul 2024

Study highlights the role of RGS16 in glioma progression

Gang Li et al., at Department of Neurosurgery, Qilu Hospital, Shandong University, China, presented a comprehensive study on the role of regulator of G-protein signaling 16 (RGS16) in the progression of glioma, a highly aggressive central nervous system tumor.

17 Jul 2024

Researchers identify ORF6 protein as key to SARS-CoV-2 immune evasion

An article published in the journal Cell describes a study that enabled a group of researchers to discover how SARS-CoV-2 evades the cytotoxic immune response by identifying a protein called ORF6 that is a key factor in this mechanism.

16 Jul 2024

CePA: Novel nanomedicine for alleviating MASH via mTOR repression

Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most common chronic liver diseases, primarily caused by metabolic disorders and systemic inflammatory responses.

16 Jul 2024

ARPA-H funding boosts Wyss Institute's RNA therapeutic project

With the award for up to $27 million from the Advanced Research Projects Agency for Health (ARPA-H), a collaborative research project at the Wyss Institute for Biologically Inspired Engineering at Harvard University will advance a disease-agnostic novel RNA therapeutic with the potential to treat diverse diseases, and to be effectively and rapidly deployable.

15 Jul 2024

Mogrify appoints Dr. Jonathan Appleby as Chief Scientific Officer

Strategic hire bolsters executive leadership team as Company progresses multiple therapeutic programs toward and into clinical development.

From Mogrify 15 Jul 2024

One-time prime editing targets common genetic cause of cystic fibrosis

Researchers optimized prime editing for the efficient correction of the cystic fibrosis transmembrane conductance regulator F508del mutation in human airway epithelial cells, achieving high correction efficiencies and functional restoration with minimal off-target effects.

15 Jul 2024

Twincretin drug Tirzepatide shows unmatched efficacy in weight loss and diabetes management

Tirzepatide, a novel twincretin drug, significantly improves weight loss and glycemic control in obese and type 2 diabetes patients, outperforming traditional treatments in clinical trials.

15 Jul 2024