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Olive oil-based emulsion shows promise for mycobacterial treatment of bladder cancer

Researchers at the Universitat Autònoma de Barcelona with the collaboration of the Institute for Bioengineering of Catalonia, led by the professor of the UAB Department of Genetics and Microbiology Esther Julián, announced one year ago that the cells of the Mycobacterium brumae offer an improved alternative to current bladder cancer treatments such as BCG (an immunotherapy based on the Mycobacterium bovis), which can cause infections.

23 Jun 2016

Highly efficient bacterial agent could improve treatment of Wilson disease

In the 'Journal of Clinical Investigation', scientists at the Helmholtz Zentrum München describe a small peptide that very efficiently binds excess copper from liver cells. This molecule comes from a bacterium's bag of tricks and could be suitable for treating Wilson disease.

21 Jun 2016

Novel methods may help assess multipotent or unipotent fate of mammary gland, prostate stem cells

Stem cells ensure the development of tissues, their daily maintenance and their repair following injuries. One of the key questions in the field of stem cell biology is to define the different cell lineages in which stem cells can differentiate into.

9 Jun 2016

Drug candidate delivered by plant-virus-based carrier shows promise for triple-negative breast cancer

In a pair of firsts, researchers at Case Western Reserve University and Massachusetts Institute of Technology have shown that the drug candidate phenanthriplatin can be more effective than an approved drug in vivo, and that a plant-virus-based carrier successfully delivers a drug in vivo.

9 Jun 2016

Mathematical approach can help achieve optimal dosing for various drugs

In treating diseases with drugs, dosing is critical; too little is ineffective, while too much can be lethal. Colorado State University's Brad Reisfeld takes a mathematical approach to achieving optimal dosing for various drugs.

9 Jun 2016

Boosting mitochondria transport may facilitate neuronal regeneration

Researchers at the National Institute of Neurological Disorders and Stroke have discovered that boosting the transport of mitochondria along neuronal axons enhances the ability of mouse nerve cells to repair themselves after injury.

8 Jun 2016

Coagadex now available for rare bleeding disorder patients in the UK

Bio Products Laboratory, Limited (BPL) today announced that Coagadex is now available for patients in the UK.

7 Jun 2016

Innovative mouse model could provide new strategy to arrest growth of pancreatic cancer

Pancreatic ductal adenocarcinoma, the most common of pancreatic cancers, is extraordinarily lethal, with a 5-year survival rate of just 6 percent. Chemotherapy treatments are poorly effective, in part due to a high degree of drug-resistance to currently used regimens.

7 Jun 2016

Researchers establish new method to culture kidney progenitor cells for regenerative medicine

Research into kidney regeneration, an organ that has been extremely difficult to regenerate, has taken a great stride forward with research coming out of a collaboration between Kumamoto University, Japan and the National Cancer Institute of the US.

7 Jun 2016

UA researcher aims to identify imaging biomarkers for effective screening of ovarian cancer

University of Arizona researcher Jennifer Barton is leading a two-year, $1 million project funded by the National Cancer Institute to identify imaging biomarkers of ovarian cancer, the most deadly gynecological cancer in the United States.

1 Jun 2016

New CRISPR-EZ method makes genome editing much easier in mice

University of California, Berkeley scientists have developed a quicker and more efficient method to alter the genes of mice with CRISPR-Cas9, simplifying a procedure growing in popularity because of the ease of using the new gene-editing tool.

28 May 2016

Applying deep neural networks to predict pharmacologic properties of drugs and drug repurposing

Deep learning, frequently referred to as artificial intelligence, a branch of machine learning utilizing multiple layers of neurons to model high-level abstractions in data, has outperformed humans in tasks including image, text and voice recognition, autonomous driving and others, and is now being applied to drug discovery and biomarker development.

28 May 2016

External stimulation guides brain circuit’s early development

A healthy brain has just the right ratio of cells that enhance signals (excitatory neurons) and cells that tone down signals (inhibitory neurons). These two sets of neurons start out looking exactly the same, so what determines their roles?

27 May 2016

Technical advances in neuroimaging offer new promise to clinicians

The current special issue of Technology and Innovation, Journal of the National Academy of Inventors, Volume 18, Number 1 (all open access), is devoted to the evolution of neuroimaging technology, with seven articles chronicling the latest advances in this critical area.

25 May 2016

Cornell researchers develop nanoparticle-based drug delivery mechanism for combination cancer therapy

A team of researchers from Cornell University in Ithaca, New York demonstrated a drug delivery mechanism that utilizes two independent vehicles, allowing for delivery of chemically and physically dis-tinct agents.

23 May 2016

Small lipid nanocarrier may deliver chemotherapeutic drug more efficiently to brain tumor cells

Great discoveries do come in small packages. Few know that better than Ann-Marie Broome, Ph.D., who feels nanotechnology holds the future of medicine with its ability to deliver powerful drugs in tiny, designer packages.

23 May 2016

New Spherical Brain Mapping for dementia diagnosis

Diagnosis, treatment and care of dementia is one of the major concerns in neurology research and associated healthcare programs. Dementia affects older age groups with a greater frequency, and as our population ages, the burden of dementia on public health is rapidly increasing.

23 May 2016

Natural proteins could be used to test new replacement hip, knee joints

A new study suggests that natural proteins can be used to effectively test new replacement hip and knee joints in the laboratory. The work could help with improving design in order to reduce wear and tear and increase the lifespan of such prosthetics.

20 May 2016

Innovative research technique may help understand early stage kidney disease

UT Dallas scientists are developing an innovative research technique that could help urologists better understand the early stages of kidney disease.

19 May 2016

Pediatric feasibility study results set stage for clinical trial of world’s first bioabsorbable heart valve enabling Endogenous Tissue Restoration

One-year follow-up results from a pediatric feasibility study of Xeltis bioabsorbable cardiovascular pulmonary graft have been presented as late-breaker at the 96th American Association for Thoracic Surgery annual meeting today.

19 May 2016

in vivo News and Research

Olive oil-based emulsion shows promise for mycobacterial treatment of bladder cancer

Highly efficient bacterial agent could improve treatment of Wilson disease

Novel methods may help assess multipotent or unipotent fate of mammary gland, prostate stem cells

Drug candidate delivered by plant-virus-based carrier shows promise for triple-negative breast cancer

Mathematical approach can help achieve optimal dosing for various drugs

Boosting mitochondria transport may facilitate neuronal regeneration

Coagadex now available for rare bleeding disorder patients in the UK

Innovative mouse model could provide new strategy to arrest growth of pancreatic cancer

Researchers establish new method to culture kidney progenitor cells for regenerative medicine

UA researcher aims to identify imaging biomarkers for effective screening of ovarian cancer

New CRISPR-EZ method makes genome editing much easier in mice

Applying deep neural networks to predict pharmacologic properties of drugs and drug repurposing

External stimulation guides brain circuit’s early development

Technical advances in neuroimaging offer new promise to clinicians

Cornell researchers develop nanoparticle-based drug delivery mechanism for combination cancer therapy

Small lipid nanocarrier may deliver chemotherapeutic drug more efficiently to brain tumor cells

New Spherical Brain Mapping for dementia diagnosis

Natural proteins could be used to test new replacement hip, knee joints

Innovative research technique may help understand early stage kidney disease

Pediatric feasibility study results set stage for clinical trial of world’s first bioabsorbable heart valve enabling Endogenous Tissue Restoration

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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