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Combining photoimmunotherapy and gene transduction effective against elusive gastric cancer cells

Researchers report photoimmunotherapy to be effective against elusive gastric cancer cells following transduction with the gene that expresses the extracellular domain protein of HER2. The results are published in the journal Small Molecule Therapeutics in February 2016.

15 Mar 2016

Real maple syrup shows promise in protecting brain health

As part of a two-day symposium at the annual meeting of the American Chemical Society, a group of international scientists shared promising results of 24 studies exploring the beneficial effects of natural products on the prevention of neurodegenerative diseases, particularly Alzheimer's disease.

14 Mar 2016

Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

microRNAs (miRs) are small endogenous noncoding RNA molecules (20–23 nucleotides) derived from imperfectly paired hairpin RNA structures naturally encoded in the genome that act specifically as triggering molecules to control translational repression or mRNA degradation.

11 Mar 2016

Hematopoietic reprogramming can lead to differentiated blood products for cell-replacement therapy

Building upon previous work, researchers at the Icahn School of Medicine at Mount Sinai identified cells in the embryos of mice that are precursors to blood stem cells or hematopoietic stem/progenitor cells.

9 Mar 2016

Metabolic syndrome treatment benefits MS patients

Oral antidiabetic medications have beneficial anti-inflammatory effects in patients with multiple sclerosis and metabolic syndrome, providing support for a link between metabolism and autoimmunity, researchers report.

9 Mar 2016

Renishaw inVia to support development of nanomolecular probes in Kircher Laboratory at Memorial Sloan Kettering

The Kircher laboratory at Memorial Sloan Kettering is developing novel nanoprobes for molecular imaging, image-guided therapy and theranostics.

4 Mar 2016

New robotic platform can help make future robotic surgery much safer, less invasive

Initiated by Professor Yeung Chung-Kwong (Prof Yeung), Honorary Clinical Professor, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, a team of experienced engineers led by Professor Yung Kai-Leung (Prof Yung), Professor and Associate Head of the Department of Industrial and Systems Engineering of The Hong Kong Polytechnic University was invited to develop the system as an engineering partner since 2012.

4 Mar 2016

Unlocking H5N1 virus replication: an interview with Martin Blackledge

We were able to show that one small domain of the polymerase, the part that is essential for entry of a piece of the polymerase into the cell nucleus, changes its conformation to allow it to interact with the transporter protein than takes it into the nucleus.

3 Mar 2016

Researchers discover unexpected mechanism linked to aldosterone-induced heart damage

When the heart begins to fail, the body does everything in its power to fix the situation. But sometimes, those compensatory mechanisms ultimately do more harm than good. Such is the case with the adrenal hormone aldosterone, which stimulates the heart to pump harder, causing greater damage to the heart muscle.

3 Mar 2016

Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Researchers show that the protein CCN4 positively regulates the generation of cartilage matrix, which are depleted in osteoarthritis.

2 Mar 2016

Advances in the field of MPI: an interview with Professor Kannan Krishnan

In around 2004, there was a Phillips paper that discussed a new imaging technique called MPI. At that time, I had an eager, promising graduate student named Matt Ferguson who wanted a project, so I asked him to take a look.

From Bruker BioSpin - NMR, EPR and Imaging 1 Mar 2016

Novel mitochondria-specific ceria nanoparticles can effectively suppress neuronal cell death

The brain is an enormous network of communication, containing over 100 billion nerve cells, or neurons, with branches that connect at more than 100 trillion points. They are constantly sending signals through a vast neuron forest that forms memories, thoughts and feelings; these patterns of activity form the essence of each person.

27 Feb 2016

MR Solutions introduces new 3D in vivo confocal microscope for preclinical research

MR Solutions’ new 3D in vivo confocal microscope for use in preclinical research provides a magnification range of up to 1000 times, allowing researchers to examine cellular details within a live small animal eliminating the need for a surgical biopsy - saving time and substantially reducing costs.

From MR Solutions 24 Feb 2016

New project aims to develop low-cost device that can detect drug allergies within 30 minutes

The Universitat Politècnica de València (Polytechnic University of Valencia, UPV) is at the helm of a new Horizon2020 research project to develop a low-cost biophotonic device that can detect drug allergies within 30 minutes. Going by the acronym "Cobiophad", short for Compact Biophotonic Platform for Drug Allergy Diagnosis, it also receives funding from the European Technology Platform Photonics 21.

19 Feb 2016

Parvus' novel therapeutic approach employing nanomedicines published in Nature

Parvus Therapeutics today announced the publication in Nature of a seminal paper describing the discovery and applications of a novel therapeutic approach employing nanomedicines, referred to as "Navacims"TM, to reprogram white blood cells to become regulatory cells capable of blunting autoimmune responses and restoring the equilibrium of the immune system.

19 Feb 2016

Researchers make some progress in determining causes for glioblastoma multiforme

A research team, with the participation of the University of Granada (UGR), has made some progress in determining the causes for glioblastoma multiforme (GBM), one of the most aggressive brain tumors known, to be resistant to the drugs currently used, which is one of the main limitations of its treatment.

18 Feb 2016

Mtss1 'tumour suppressor' for CML

The metastasis suppressor 1 protein acts a tumour suppressor in chronic myeloid leukaemia stem cells, reveals research published in Leukemia.

17 Feb 2016

Polyphenolic compounds in mango linked to anti-cancer, anti-inflammatory properties

Mangos contain numerous compounds that have been shown to exhibit antioxidant properties. These compounds include vitamin C and beta carotene, as well as several polyphenolic compounds including gallic acid and their larger polymers gallotannins,that have been linked to anti-cancer and anti-inflammatory activities in previous in vitro and in vivo studies.

17 Feb 2016

Understanding the pathophysiology of bipolar disorder

Advances in magnetic resonance imaging (MRI) acquisition and analyses over the last two decades have enabled the identification of neuroanatomical abnormalities in a range of mental disorders, however one question which has consistently surfaced is the extent to which the medications used to treat such disorders may accentuate or ameliorate these abnormalities.

17 Feb 2016

TUM researchers make progress in bringing immunotherapy to fight against cancer, infectious diseases

The quest to bring immunotherapy into widespread clinical use against cancer and infectious diseases has made great strides in recent years.

15 Feb 2016

in vivo News and Research

Combining photoimmunotherapy and gene transduction effective against elusive gastric cancer cells

Real maple syrup shows promise in protecting brain health

Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

Hematopoietic reprogramming can lead to differentiated blood products for cell-replacement therapy

Metabolic syndrome treatment benefits MS patients

Renishaw inVia to support development of nanomolecular probes in Kircher Laboratory at Memorial Sloan Kettering

New robotic platform can help make future robotic surgery much safer, less invasive

Unlocking H5N1 virus replication: an interview with Martin Blackledge

Researchers discover unexpected mechanism linked to aldosterone-induced heart damage

Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Advances in the field of MPI: an interview with Professor Kannan Krishnan

Novel mitochondria-specific ceria nanoparticles can effectively suppress neuronal cell death

MR Solutions introduces new 3D in vivo confocal microscope for preclinical research

New project aims to develop low-cost device that can detect drug allergies within 30 minutes

Parvus' novel therapeutic approach employing nanomedicines published in Nature

Researchers make some progress in determining causes for glioblastoma multiforme

Mtss1 'tumour suppressor' for CML

Polyphenolic compounds in mango linked to anti-cancer, anti-inflammatory properties

Understanding the pathophysiology of bipolar disorder

TUM researchers make progress in bringing immunotherapy to fight against cancer, infectious diseases

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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