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Research brief describes enrollment of first patient with TRK fusion cancer in LOXO-101 Phase 1 trial

The University of Colorado Cancer Center and Loxo Oncology, Inc., a biopharmaceutical company focused on the discovery, development and commercialization of targeted cancer therapies, today announced the publication of a research brief in the online edition of the journal Cancer Discovery, describing the first patient with a tropomyosin receptor kinase (TRK) fusion cancer enrolled in the Phase 1 dose escalation trial of LOXO-101, the only selective TRK inhibitor in clinical development.

28 Jul 2015

New technology enhances investigations of epigenomes

A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation, inflammation and cancer, is reported on today in the research journal Nature Methods.

28 Jul 2015

Scientists reveal potential therapeutic approach to idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis is a very aggressive form of pulmonary fibrosis and has a particularly poor prognosis. This fatal disease, for which so far no causal therapies exist, is characterized by a massive deposition of connective and scar tissue in the lung, which leads to a progressive loss of lung function and ultimately death.

28 Jul 2015

Bosutinib resistance linked to ABCB1 transporter

Resistance to the tyrosine kinase inhibitor bosutinib may be mediated by overexpression of the efflux transporter ABCB1, scientists suggest.

24 Jul 2015

Resveratrol and quercetin may improve efficacy of existing chemotherapeutic cancer drug

Resveratrol and quercetin, two polyphenols that have been widely studied for their health properties, may soon become the basis of an important new advance in cancer treatment, primarily by improving the efficacy and potential use of an existing chemotherapeutic cancer drug.

17 Jul 2015

Impingement testing added to Lucideon’s orthopedic implant testing services

Lucideon, the international materials technology company, has added impingement testing to its range of services for orthopedic implant manufacturers.

From Lucideon 16 Jul 2015

Study shows that 14-3-3 sigma opposes, reverses tumor-promoting metabolic programs

Every parent knows the maxim "feed a cold, starve a fever." In cancer, however, exactly how to feed or starve a tumor has not been easy to determine.

16 Jul 2015

Futura Medical develops new generation of topical pain relief

Futura Medical has developed a "new generation" of topical pain relief with two products that target more active ingredients directly to the point of pain. The new products have the potential to transform the pain relief market, according to chief executive James Barder.

15 Jul 2015

New analysis explores importance of medical imaging in drug development, understanding pathological physiology

The use of small animal models in basic and preclinical research is now an integral part of developing and testing new pharmaceutical drugs prior to commercialisation.

14 Jul 2015

Researchers identify genetic abnormalities that lead to skin SCC

Squamous cell carcinoma (SCC) of the skin is one of the most frequent cancers in humans affecting more than half million new persons every year in the world. The transformation of a normal cell to a cancer cell is caused by an accumulation of genetic abnormalities in the progeny of single cells. The spectrum of genetic anomalies found in a variety of human cancers have been described.

14 Jul 2015

Study shows that Anisina has potential to improve effectiveness of chemotherapy in children with cancer

US-Australian drug discovery company, Novogen Limited, today announced details of an in vivo proof of concept study that demonstrates their lead anti-tropomyosin drug candidate, Anisina, has the potential to improve the effectiveness of chemotherapy in children and reduce life-long side-effects.

14 Jul 2015

MPI applications: an interview with Tobias Knopp, University Hospital Hamburg

Up to now, we've seen a lot of improvements made, but now we're almost at the point of focusing on the application of MPI and proving what the real benefits of this technology are, which is very exciting...

From Bruker BioSpin - NMR, EPR and Imaging 12 Jul 2015

Elsevier, NCI implement two-way linking between research articles on ScienceDirect and datasets in caNanoLab

Elsevier, a world-leading provider of scientific, technical and medical information products and services, and the US National Cancer Institute, a world-leading institute for cancer research, today announced that they have implemented two-way linking between research articles on ScienceDirect and datasets stored in NCI's cancer Nanotechnology Laboratory (caNanoLab) data portal.

9 Jul 2015

Retinal function, structure changes in proliferative diabetic retinopathy revealed

Patients with proliferative diabetic retinopathy exhibit marked visual dysfunction and structural changes in both the inner and outer retinal layers, research findings indicate.

8 Jul 2015

Dental pulp stem cell transplants can contribute to peripheral nerve regeneration

Peripheral nerve injuries often are caused by trauma or surgical complications and can result in considerable disabilities. Regeneration of peripheral nerves can be accomplished effectively using autologous (self-donated) nerve grafts, but that procedure may sacrifice a functional nerve and cause loss of sensation in another part of the patient's body.

7 Jul 2015

AOSSM to present awards and grants to encourage cutting-edge research in orthopaedic sports medicine

In order to recognize and encourage cutting-edge research in key areas of orthopaedic sports medicine, the American Orthopaedic Society for Sports Medicine will present ten research awards and seven grants during its Annual Meeting, July 9-12 in Orlando, FL.

7 Jul 2015

European Nanomedicine Characterization Lab aims to bring safe, efficient nano-therapeutics to patients

Empa, the Swiss Federal Laboratories for Materials Science and Technology, is part of the European Nanomedicine Characterization Laboratory, a European project funded by the EU framework program «Horizon 2020.

2 Jul 2015

Angiography and MPI: an interview with Professor Mauro Magnani University of Urbino

I am Mauro Magnani, Professor of Biochemistry at the University of Urbino, Italy. My background is essentially the transition of activity from the lab to application. I am also the founder of a spin-off company called EryDel, which uses technology to load materials or drugs inside cells.

From Bruker BioSpin - NMR, EPR and Imaging 30 Jun 2015

Hartmuth Kolb named recipient of 2015 Alzheimer Award

The Journal of Alzheimer's Disease is proud to announce that Hartmuth Kolb, PhD, Head of Neuroscience Biomarkers, Johnson & Johnson, San Diego, CA, has been chosen as the recipient of the 2015 Alzheimer Award presented by the Journal of Alzheimer's Disease in recognition of his outstanding work on the importance and imaging of neurofibrillary tangles (NFTs) and Alzheimer's disease (AD).

26 Jun 2015

Study finds an organic cause for patients with functional dyspepsia

How many times patients with gastrointestinal disorders have been told "There is nothing wrong, nothing organic, it's all you head". But the pain is real.

24 Jun 2015

in vivo News and Research

Research brief describes enrollment of first patient with TRK fusion cancer in LOXO-101 Phase 1 trial

New technology enhances investigations of epigenomes

Scientists reveal potential therapeutic approach to idiopathic pulmonary fibrosis

Bosutinib resistance linked to ABCB1 transporter

Resveratrol and quercetin may improve efficacy of existing chemotherapeutic cancer drug

Impingement testing added to Lucideon’s orthopedic implant testing services

Study shows that 14-3-3 sigma opposes, reverses tumor-promoting metabolic programs

Futura Medical develops new generation of topical pain relief

New analysis explores importance of medical imaging in drug development, understanding pathological physiology

Researchers identify genetic abnormalities that lead to skin SCC

Study shows that Anisina has potential to improve effectiveness of chemotherapy in children with cancer

MPI applications: an interview with Tobias Knopp, University Hospital Hamburg

Elsevier, NCI implement two-way linking between research articles on ScienceDirect and datasets in caNanoLab

Retinal function, structure changes in proliferative diabetic retinopathy revealed

Dental pulp stem cell transplants can contribute to peripheral nerve regeneration

AOSSM to present awards and grants to encourage cutting-edge research in orthopaedic sports medicine

European Nanomedicine Characterization Lab aims to bring safe, efficient nano-therapeutics to patients

Angiography and MPI: an interview with Professor Mauro Magnani University of Urbino

Hartmuth Kolb named recipient of 2015 Alzheimer Award

Study finds an organic cause for patients with functional dyspepsia

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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