in vivo News and Research

RSS

Allele-specific lncRNA regulates cancer metabolism

Long non-coding RNAs (lncRNA) are unusual in that they don't encode proteins like normal RNA. Yet they do play a role in regulating cellular functions and interest cancer researchers.

21 Apr 2015

New combination therapy could overcome treatment resistance, relapse in breast cancer

Researchers from The University of Manchester working with drug development company Evgen Pharma, have developed a new combination of drugs which could overcome treatment resistance and relapse in breast cancer.

21 Apr 2015

New mathematical model to predict pharmacodynamic activity may help improve drug discovery

A new mathematical model that uses drug-target kinetics to predict how drugs work in vivo may provide a foundation to improve drug discovery, which is frequently hampered by the inability to predict effective doses of drugs.

21 Apr 2015

Ibrutinib (IMBRUVICA) may be effective for pancreatic ductal adenocarcinoma

Ibrutinib (IMBRUVICA) data presented yesterday by Pharmacyclics, Inc. at the American Association for Cancer Research Annual Meeting suggest that ibrutinib may be an effective therapeutic option for pancreatic ductal adenocarcinoma (PDAC), as shown in both a transgenic mouse model and an in-vivo model of patient-derived xenograft (PDX) mice (grafts of tissue taken from a pancreatic cancer patient and grafted into a mouse).

20 Apr 2015

Maple syrup makes disease-causing bacteria more susceptible to antibiotics, study shows

A concentrated extract of maple syrup makes disease-causing bacteria more susceptible to antibiotics, according to laboratory experiments by researchers at McGill University.

17 Apr 2015

Electronic micropump combined with anticonvulsant drug may treat brain diseases

Many potentially efficient drugs have been created to treat neurological disorders, but they cannot be used in practice. Typically, for a condition such as epilepsy, it is essential to act at exactly the right time and place in the brain.

16 Apr 2015

Houston Methodist researchers discover new, ex vivo lung cancer model to study tumor progression

Without good models to study cancer metastasis -- the spread of cancer cells from one organ to another -- cancer researchers have struggled to understand tumor progression fully, and new therapies targeting the main causes of death are slow to come.

16 Apr 2015

LaVision BioTec reports on the Beatson Institute for Cancer Research and their use of multiphoton microscopy to understand the behaviour of cells in cancer metastasis

LaVison BioTec, developers of advanced microscopy solutions for the life sciences, report on the research of Professor Kurt I Anderson and his groups' studies of cell migration in the context of cancer metastasis at the Beatson Institute for Cancer Research...

14 Apr 2015

Watching the blood flow

Optical microangiography (OMAG), a technique based on optical coherence tomography, can be used to visualize the microvasculature network under inflamed skin condition. It opens up new vistas for clinical trials of treatment and diagnosis of inflammatory skin disorders.

7 Apr 2015

Journal of Drugs in Dermatology publishes findings on new injectable drug ATX-101

The Journal of Drugs in Dermatology is pleased to publish findings on a new injectable drug currently under development by Kythera Biopharmaceuticals, Inc. (Westlake Village, CA) that may provide a non-surgical alternative for people with double chins.

6 Apr 2015

Penn Med's BLINKER Team named one of 16 finalists in NIH 'Follow that Cell Challenge'

James Eberwine, PhD, the Elmer Holmes Bobst Professor of Systems Pharmacology and Experimental Therapeutics, at the Perelman School of Medicine at the University of Pennsylvania, was named one of 16 finalists in the first phase of the Follow that Cell Challenge funded by the National Institutes of Health. The competition was run by crowdsourcing company Innocentive and 687 designated "solvers" entered initially.

2 Apr 2015

Iron oxide nanoparticles selectively target cell surface markers in tumor microenvironments

Nanoparticles hold great promise for cancer diagnostics and therapies, but only to the extent that they can be selectively guided to tumors and cancer cells.

30 Mar 2015

Mitochondrial DNA movement: an interview with Professor Jiri Neuzil, Griffith University

According to our understanding, mitochondria undergo cycles of fusion-fission, i.e. they divide within the constraints of a cell and, upon cell division, each of the two daughter cells gets its ‘share’ of mitochondria.

29 Mar 2015

Experts unveil strategic roadmap to advance treatments for people with lymphoma

A committee of lymphoma experts today unveiled a strategic roadmap identifying key priority areas in both infrastructure and research that will be critical for advancing treatments for people with lymphoma.

27 Mar 2015

Arno Therapeutics' AR-42 with cisplatin demonstrates anti-tumor effect in bladder cancer models

Arno Therapeutics, Inc., a clinical stage biopharmaceutical company primarily focused on the development of oncology therapeutics, today announced that data from a preclinical study demonstrate its histone-deacetylase (HDAC) inhibitor AR-42 in combination with cisplatin has a synergistic anti-tumor effect in bladder cancer models.

26 Mar 2015

Broad Institute of MIT researcher honored for groundbreaking research using new gene editing tool

The newest gene editing tool - called CRISPR-Cas9 - is leading to new research possibilities in cell biology and neuroscience. This includes the ability to make transgenic animal models more quickly, which helps researchers better study diseases that affect thousands of people each year.

25 Mar 2015

Canfield to become sole supplier of PRIMOS family of 3D optical systems worldwide

Demonstrating its commitment to delivering best-in-class clinical research solutions, Canfield Scientific has been named the exclusive worldwide distributor of the highly respected PRIMOS family of 3D optical systems.

21 Mar 2015

Denator's heat-stabilization system preserves lipids at close-to-in vivo-levels

Denator AB announced today that the company’s heat-stabilization system has been demonstrated to preserve lipids at close-to-in vivo-levels. To preserve lipids in a reliable manner prior to mass spectrometry-based analysis is pivotal to accurately quantify and identify potential biomarkers and perform disease research.

19 Mar 2015

Transplanted regulatory T cells may help in controlling inflammatory diseases

With a $2 million grant from the National Institutes of Health, a team of researchers - including Rensselaer Polytechnic Institute professor Juergen Hahn - will investigate the potential of using transplanted regulatory T cells (Tregs) to reduce inflammation in diseases like inflammatory bowel disease, which currently has no known viable treatment options.

19 Mar 2015

Exposure to diesel exhaust may exacerbate respiratory diseases

Researchers in the UK have, for the first time, shown how exhaust pollution from diesel engines is able to affect nerves within the lung. Air pollution is a significant threat to health, they say, and identifying potential mechanisms linking exposure to diesel exhaust and the exacerbation of respiratory diseases may lead to treatments for those affected.

16 Mar 2015

in vivo News and Research

Allele-specific lncRNA regulates cancer metabolism

New combination therapy could overcome treatment resistance, relapse in breast cancer

New mathematical model to predict pharmacodynamic activity may help improve drug discovery

Ibrutinib (IMBRUVICA) may be effective for pancreatic ductal adenocarcinoma

Maple syrup makes disease-causing bacteria more susceptible to antibiotics, study shows

Electronic micropump combined with anticonvulsant drug may treat brain diseases

Houston Methodist researchers discover new, ex vivo lung cancer model to study tumor progression

LaVision BioTec reports on the Beatson Institute for Cancer Research and their use of multiphoton microscopy to understand the behaviour of cells in cancer metastasis

Watching the blood flow

Journal of Drugs in Dermatology publishes findings on new injectable drug ATX-101

Penn Med's BLINKER Team named one of 16 finalists in NIH 'Follow that Cell Challenge'

Iron oxide nanoparticles selectively target cell surface markers in tumor microenvironments

Mitochondrial DNA movement: an interview with Professor Jiri Neuzil, Griffith University

Experts unveil strategic roadmap to advance treatments for people with lymphoma

Arno Therapeutics' AR-42 with cisplatin demonstrates anti-tumor effect in bladder cancer models

Broad Institute of MIT researcher honored for groundbreaking research using new gene editing tool

Canfield to become sole supplier of PRIMOS family of 3D optical systems worldwide

Denator's heat-stabilization system preserves lipids at close-to-in vivo-levels

Transplanted regulatory T cells may help in controlling inflammatory diseases

Exposure to diesel exhaust may exacerbate respiratory diseases

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News