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CD98hc molecule appears to be necessary for rapid and effective skin renewal

These mechanisms, described in vivo in mice, engage molecule CD98hc, which is involved in epidermis renewal and could be an indicator of the skin's capacity for regeneration.

23 Jan 2013

UB scientists propose first genomic explanation for schizophrenia

New University at Buffalo research demonstrates how defects in an important neurological pathway in early development may be responsible for the onset of schizophrenia later in life.

23 Jan 2013

Imaging supports Braak Parkinson’s staging

A magnetic resonance imaging study supports the hypothesis that degeneration occurs in the substantia nigra pars compacta before the basal forebrain in patients with Parkinson’s disease.

22 Jan 2013

Neuronal reprogramming may help treat neurodegenerative diseases

A new finding by Harvard stem cell biologists turns one of the basics of neurobiology on its head - demonstrating that it is possible to turn one type of already differentiated neuron into another within the brain.

22 Jan 2013

Biophysical Society Annual Meeting to highlight innovations in medicine, physics, and more

Honeybee silk-inspired materials; a deconstruction of the Ebola virus; how microbes evolve resistance to antibiotics; and a possible connection between Alzheimer's disease and type II diabetes are just some of the intriguing topics that will be presented at the 57th Annual Meeting of the Biophysical Society (BPS).

22 Jan 2013

G-quadruplexes also exist within the human genome

In 1953, Cambridge researchers Watson and Crick published a paper describing the interweaving 'double helix' DNA structure - the chemical code for all life.

21 Jan 2013

Positive data from NinePoint Medical endomicroscopy study on Barrett's esophagus

NinePoint Medical, Inc., an emerging leader in the development of medical devices for in vivo imaging, today announced that data demonstrating positive results related to a new tethered capsule endomicroscopy technology, licensed from Massachusetts General Hospital (MGH), were published online this week in the journal Nature Medicine.

18 Jan 2013

Over-expression of NEK2 in cancer cells significantly enhances drug resistance

Increased NEK2 gene expression linked to increased drug resistance, faster cancer growth, and poorer patient outcome - The finding may improved diagnostic and prognostic tools for cancer care and could lead to improved cancer therapies

16 Jan 2013

New hope for people with sound-induced deafness

Preliminary results from a study in mice suggest it may be possible to regenerate cochlear hair cells that have been damaged due to excessive noise exposure.

15 Jan 2013

Biguanide mechanism discovered

Researchers have discovered a novel mechanism by which biguanides exert their glucose-lowering effect, potentially leading to new therapeutic approaches to the treatment of diabetes and insulin resistance.

14 Jan 2013

Scientists wrestle to understand why Huntington's can produce variable symptoms

Scientists have wrestled to understand why Huntington's disease, which is caused by a single gene mutation, can produce such variable symptoms. An authoritative review by a group of leading experts summarizes the progress relating cell loss in the striatum and cerebral cortex to symptom profile in Huntington's disease, suggesting a possible direction for developing targeted therapies.

9 Jan 2013

Scientists discover process by which mda-9/syntenin contributes to melanoma metastasis

After recently announcing success in eliminating melanoma metastasis in laboratory experiments, scientists at Virginia Commonwealth University Massey Cancer Center have made another important discovery in understanding the process by which the gene mda-9/syntenin contributes to metastasis in melanoma (the spread of skin cancer) and possibly a variety of other cancers.

4 Jan 2013

New insight into structure of Cathepsin B protein

Using the world's most powerful X-ray free-electron laser, an international team of researchers, including scientists of the Max Planck Institute for Medical Research in Heidelberg, has obtained new insight into the structure of a medicinally important protein that may serve as a blueprint for the development of drugs to fight sleeping sickness. Science magazine have chosen the experimental study as one of the top ten scientific breakthroughs of the year.

21 Dec 2012

Iron oxide nanoparticles could help track transplanted human endothelial cells

A team of researchers from three medical institutions in Guangzhou, China, have found that iron oxide nanoparticles (INOPS) are a useful contrast agent for in vivo magnetic resonance tracking of transplanted human endothelial cells.

21 Dec 2012

Researchers track adipose tissue-derived stromal cells after transplantation

Using mesenchymal stromal cells derived from adipose (fat) tissues, genetically modified to express a bioluminescent marker, researchers in Italy have tracked cells after transplantation. The cells were followed from their injection into the spleen of mice modeling liver disease, to their characterization as "hepatic precursors," and to their subsequent migration through the spleen before engrafting at regenerating sites in the liver by bioluminescent imaging.

21 Dec 2012

Lymphocyte clue to multiple sclerosis drug response

Patients with rapid recovery of CD4-positive T cells after alemtuzumab treatment for multiple sclerosis are at risk for disease progression or relapse, research suggests.

18 Dec 2012

AHA/ASA identify top cardiovascular and stroke research advances for 2012

Resuscitation, cell regeneration, a new high blood pressure treatment and developments in devices for treating stroke are among the key scientific findings that make up this year's top cardiovascular and stroke research identified by the American Heart Association and American Stroke Association.

18 Dec 2012

Pairing statins with cyclin-dependent kinase inhibitors might effectively treat melanomas

A novel approach to identifying potential anticancer drug combinations revealed that pairing cholesterol-reducing drugs called statins with cyclin-dependent kinase inhibitors might provide an effective approach to treating intractable melanomas driven by mutations in the NRAS and KRAS gene.

14 Dec 2012

Ultradian Diagnostics announces publication of clinical study results for Biologue

Ultradian Diagnostics LLC, an early-stage medical device company based in Rensselaer, New York, today announced the publication of clinical study results for Biologue, the Company's minimally invasive continuous glucose monitoring (CGM) system, in the November 2012 issue of the Journal of Diabetes Science and Technology.

13 Dec 2012

Interim results from Inspiration’s OBI-1 and IB1001 hemophilia clinical study

Inspiration Biopharmaceuticals, Inc. (Inspiration) announced interim clinical results for the company's two lead product candidates, an intravenous recombinant porcine FVIII (OBI-1) in the treatment of serious bleeds in acquired hemophilia A (AHA) and an intravenous recombinant FIX (IB1001) for the treatment and prevention of bleeding in children less than 12 years of age with hemophilia B.

13 Dec 2012