siRNA News and Research

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Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 nucleotides in length, that play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g., as an antiviral mechanism or in shaping the chromatin structure of a genome; the complexity of these pathways is only now being elucidated.
Chinese scientists reveal key role of lysosome cell death regulator in lung tumor survival

Chinese scientists reveal key role of lysosome cell death regulator in lung tumor survival

SARS-CoV-2 VOCs dependent on IFITM2 for efficient infection establishment

SARS-CoV-2 VOCs dependent on IFITM2 for efficient infection establishment

Recycling tubular endosomes are associated with effective delivery of mRNA-based therapeutics, study finds

Recycling tubular endosomes are associated with effective delivery of mRNA-based therapeutics, study finds

An assessment of pH-sensitive cationic lipid nanoparticles for drug delivery

An assessment of pH-sensitive cationic lipid nanoparticles for drug delivery

Nanoengineers develop a new approach to effectively deliver mRNA into cells

Nanoengineers develop a new approach to effectively deliver mRNA into cells

Using metal nanoparticles to fight SARS-CoV-2

Using metal nanoparticles to fight SARS-CoV-2

IFITM proteins are important replication cofactors for SARS-CoV-2, including Delta variant

IFITM proteins are important replication cofactors for SARS-CoV-2, including Delta variant

P681H mutation helps SARS-CoV-2 VOCs replicate faster and resist innate immunity

P681H mutation helps SARS-CoV-2 VOCs replicate faster and resist innate immunity

New method for safe engineering of therapeutic cells with photothermal nanofibers

New method for safe engineering of therapeutic cells with photothermal nanofibers

Scientists develop an extremely potent siRNA with broad activity against SARS-CoVs

Scientists develop an extremely potent siRNA with broad activity against SARS-CoVs

The role of inhibiting palmitoylation of the SARS-CoV-2 spike protein on viral infectivity

The role of inhibiting palmitoylation of the SARS-CoV-2 spike protein on viral infectivity

Role of S-acylation in SARS-CoV-2 infectivity

Role of S-acylation in SARS-CoV-2 infectivity

Research reveals nucleolar RNA interference based on C. elegans as a model organism

Research reveals nucleolar RNA interference based on C. elegans as a model organism

Design of mRNA vaccines to combat COVID-19

Design of mRNA vaccines to combat COVID-19

Pinning down Pin1: Potential COVID-19 therapy

Pinning down Pin1: Potential COVID-19 therapy

Study shows how SARS-CoV-2 viral proteases can be targeted to stop virus replication

Study shows how SARS-CoV-2 viral proteases can be targeted to stop virus replication

Nanoparticles-assisted delivery of antiviral-siRNA for treatment of COVID-19

Nanoparticles-assisted delivery of antiviral-siRNA for treatment of COVID-19

Researchers use amphibian foam to deliver drugs for the first time

Researchers use amphibian foam to deliver drugs for the first time

SARS-CoV-2 destabilizes host RNA to improve fitness

SARS-CoV-2 destabilizes host RNA to improve fitness

Study pinpoints an enzyme with a significant impact on SARS-CoV-2 replication

Study pinpoints an enzyme with a significant impact on SARS-CoV-2 replication