siRNA News and Research

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Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 nucleotides in length, that play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g., as an antiviral mechanism or in shaping the chromatin structure of a genome; the complexity of these pathways is only now being elucidated.
From Our Bench to Yours: Antibody Advice from Proteintech

From Our Bench to Yours: Antibody Advice from Proteintech

RNAi therapy shown to alleviate preeclampsia in animal model

RNAi therapy shown to alleviate preeclampsia in animal model

Combination therapy enhances wound healing

Combination therapy enhances wound healing

Alnylam announces positive results from Phase 1/2 study of lumasiran for treating primary hyperoxaluria-1

Alnylam announces positive results from Phase 1/2 study of lumasiran for treating primary hyperoxaluria-1

Alnylam submits CTA application to MHRA to initiate Phase 1/2 study of ALN-AAT02

Alnylam submits CTA application to MHRA to initiate Phase 1/2 study of ALN-AAT02

Alnylam reports further progress on broadening the therapeutic potential of RNAi

Alnylam reports further progress on broadening the therapeutic potential of RNAi

Alnylam announces positive results from Phase 3 Study of givosiran for treating acute hepatic porphyria

Alnylam announces positive results from Phase 3 Study of givosiran for treating acute hepatic porphyria

Antioxidant in green tea helps sneak therapeutic RNAs into cells

Antioxidant in green tea helps sneak therapeutic RNAs into cells

Researchers describe novel mechanism that links epigenetic change to translational control

Researchers describe novel mechanism that links epigenetic change to translational control

EC grants marketing authorization for ONPATTRO (patisiran) in Europe

EC grants marketing authorization for ONPATTRO (patisiran) in Europe

Researchers describe link between poor oocyte development and oxidative stress in obese mice

Researchers describe link between poor oocyte development and oxidative stress in obese mice

FDA approves first targeted RNA-based treatment for rare, fatal genetic disease

FDA approves first targeted RNA-based treatment for rare, fatal genetic disease

Alnylam’s patisiran receives positive opinion from CHMP for treating hATTR amyloidosis

Alnylam’s patisiran receives positive opinion from CHMP for treating hATTR amyloidosis

Alnylam announces new positive results from Phase 1/2 study of lumasiran in patients with PH1

Alnylam announces new positive results from Phase 1/2 study of lumasiran in patients with PH1

Alnylam achieves delivery of novel siRNAs conjugates to the central nervous system

Alnylam achieves delivery of novel siRNAs conjugates to the central nervous system

Scientists discover a small family of proteins that control inclusion of DNA methylation marks in genome

Scientists discover a small family of proteins that control inclusion of DNA methylation marks in genome

Sylentis presents clinical study results of new treatment for dry eye syndrome

Sylentis presents clinical study results of new treatment for dry eye syndrome

Novel cell-based screening array reduces time and cost of drug discovery

Novel cell-based screening array reduces time and cost of drug discovery

Newly designed three-part molecule shows promise to treat breast cancers

Newly designed three-part molecule shows promise to treat breast cancers

New study shows advantages of DNA barcoding technique for identifying nanoparticles

New study shows advantages of DNA barcoding technique for identifying nanoparticles