siRNA News and Research

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Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 nucleotides in length, that play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g., as an antiviral mechanism or in shaping the chromatin structure of a genome; the complexity of these pathways is only now being elucidated.

Experimental drug found to be effective at reducing bad cholesterol

Twice-yearly injections of an experimental cholesterol-lowering drug, inclisiran, were effective at reducing low-density lipoprotein (LDL) cholesterol, often called bad cholesterol, in patients already taking the maximum dose of statin drugs, according to data of the ORION-10 trial presented Saturday, Nov. 16, at the American Heart Association's Scientific Sessions 2019.

17 Nov 2019

Peptide-based nanoparticles can suppress pancreatic cancer growth without adverse effects

Despite advances in cancer survival, more than 90 percent of people with pancreatic cancer die within five years. Most patients with pancreatic tumors (and half of those with colorectal cancers) carry a mutation in the KRAS gene, which normally controls cell growth and death.

21 Oct 2019

Common gout medications can kill elephantiasis-causing parasites

Treatment with two common FDA-approved gout medications have been found to cause rapid death to the parasites that cause elephantiasis.

3 Oct 2019

New platform uses nanoparticles to deliver anti-cancer agent to cells

Scientists from the University of Cambridge have developed a platform that uses nanoparticles known as metal-organic frameworks to deliver a promising anti-cancer agent to cells.

16 Sep 2019

Researchers identify new transmembrane protein as chloride ion channel

In the human body the salt content of cells and their surrounding is regulated by sophisticated transport systems.

14 Aug 2019

Newborn mouse model yields clues to cause of devastating gut disease in anemic preemies

Physicians have long suspected that red blood cell transfusions given to premature infants with anemia may put them in danger of developing necrotizing enterocolitis, or NEC, a potentially lethal inflammatory disease of the intestines.

From Johns Hopkins Medicine 13 Aug 2019

A non-coding RNA may play major role in memory formation

You could call this a neat discovery. Researchers at the University of Alabama at Birmingham have found that a tissue-specific, non-coding RNA called NEAT1 has a major, previously undescribed role in memory formation.

3 Jul 2019

Investigating RNA-based regulation of the cardiovascular system

Goethe University and TU Munich have jointly obtained a new Collaborative Research Centre (Sonderforschungsbereich - SFB), which will receive approximately € 11 million in funding from the German Research Foundation over the next four years.

27 May 2019

Low-dose radiation therapy may increase uptake of therapeutic nanoparticles by brain tumors

A new study led by Massachusetts General Hospital (MGH) investigators finds that radiation therapy may increase the uptake of therapeutic nanoparticles by glioblastomas, raising the possibility of using both growth-factor-targeted and immune-system-based therapies against the deadly brain tumor.

28 Mar 2019

Researchers outline targeted therapeutic strategy for triple-negative breast cancer

New findings put forth by the University of Maryland Fischell Department of Bioengineering and researchers from four other academic institutions outline a targeted therapeutic strategy to treat triple-negative breast cancer - a potential first for the particularly aggressive form of breast cancer.

26 Feb 2019

A new treatment for Chlamydia via Canadian researchers

A new way to prevent and treat one of the commonest sexually transmitted infections (STIs) has been developed by the researchers at the University of Manitoba and the University of Waterloo. This new method is more of a gene therapy than antibiotic therapy against the infection.

6 Feb 2019

Researchers develop new way to prevent and treat Chlamydia

Researchers at the University of Waterloo have developed a new way to prevent and treat Chlamydia, the most common sexually transmitted bacterial infection in the world.

6 Feb 2019

Lab model reveals the formation of new blood vessels

To provide sufficient oxygen to tissues and organs within the body, blood vessels need to sprout new offshoots to form a widespread blood supply network, much like the trunk, branches, and twigs of a tree.

31 Jan 2019

From Our Bench to Yours: Antibody Advice from Proteintech

An interview with Dr. Karolina Szczesna, discussing the tell-tale signs of a good antibody and how Proteintech are working to improve experimental results for scientists.

From Proteintech Group, Inc 5 Dec 2018

RNAi therapy shown to alleviate preeclampsia in animal model

Researcher have used a small interfering RNA (siRNA) to reduce preeclampsia symptoms in an animal model. The approach could provide a new way of treating preeclampsia in humans.

19 Nov 2018

Combination therapy enhances wound healing

By incorporating a gene-suppressing drug into an over-the-counter gel, researchers at Albert Einstein College of Medicine and their colleagues cut healing time by half and significantly improved healing outcomes compared to control treatments.

25 Oct 2018

Alnylam announces positive results from Phase 1/2 study of lumasiran for treating primary hyperoxaluria-1

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today updated positive results from its Phase 1/2 clinical study of lumasiran, an investigational, subcutaneously administered RNAi therapeutic targeting glycolate oxidase for the treatment of primary hyperoxaluria type 1.

4 Oct 2018

Alnylam submits CTA application to MHRA to initiate Phase 1/2 study of ALN-AAT02

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today that it has submitted a Clinical Trial Authorization application to the Medicines and Healthcare products Regulatory Agency to initiate a Phase 1/2 study of ALN-AAT02, an investigational RNAi therapeutic targeting alpha-1 antitrypsin for the treatment of AAT deficiency-associated liver disease.

3 Oct 2018

Alnylam reports further progress on broadening the therapeutic potential of RNAi

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today further progress on the Company's platform efforts in extrahepatic delivery of novel siRNA conjugates, including central nervous system (CNS) and ocular delivery in rat and non-human primates (NHPs).