siRNA News and Research

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Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 nucleotides in length, that play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g., as an antiviral mechanism or in shaping the chromatin structure of a genome; the complexity of these pathways is only now being elucidated.
Experimental drug protects mice from sudden death due to blood vessel rupture

Experimental drug protects mice from sudden death due to blood vessel rupture

Should siRNA-based antivirals be added to the COVID toolbox?

Should siRNA-based antivirals be added to the COVID toolbox?

What is the optimal LDL cholesterol level for patients with cardiovascular diseases?

What is the optimal LDL cholesterol level for patients with cardiovascular diseases?

New nanoparticles effectively stopped the growth and spread of ovarian, liver tumors in mice

New nanoparticles effectively stopped the growth and spread of ovarian, liver tumors in mice

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Researchers pursue a new way to use milk for delivering cancer-fighters to the brain

Researchers pursue a new way to use milk for delivering cancer-fighters to the brain

The promise of RNA medicine is targeted and personalized

The promise of RNA medicine is targeted and personalized

Investigating the role of cyclins and cyclin-dependent kinases in host restriction of SARS-CoV-2 infection

Investigating the role of cyclins and cyclin-dependent kinases in host restriction of SARS-CoV-2 infection

Probenecid shows activity against respiratory syncytial virus

Probenecid shows activity against respiratory syncytial virus

RNA interference triggers that target SARS-CoV-2 genome

RNA interference triggers that target SARS-CoV-2 genome

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Experimental siRNA therapeutic shows promise to reduce an important driver of heart disease risk

Experimental siRNA therapeutic shows promise to reduce an important driver of heart disease risk

Research demonstrates potential of local siRNA delivery as COVID antiviral therapy in the lung

Research demonstrates potential of local siRNA delivery as COVID antiviral therapy in the lung

Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Antiviral functions of interferon regulatory factors during human coronavirus infection

Antiviral functions of interferon regulatory factors during human coronavirus infection

Study identified multiple siRNAs spanning the SARS-CoV-2 genome with potent antiviral activity

Study identified multiple siRNAs spanning the SARS-CoV-2 genome with potent antiviral activity

Importance of Numb-associated kinases in SARS-CoV-2 infection

Importance of Numb-associated kinases in SARS-CoV-2 infection

Current and future perspectives of mRNA technology

Current and future perspectives of mRNA technology

Analyzing transcriptomic landscape of SARS-CoV-2-infected lung cells

Analyzing transcriptomic landscape of SARS-CoV-2-infected lung cells

Application of various nanoparticle-capsulated siRNA as therapeutics for SARS-CoV-2 infection

Application of various nanoparticle-capsulated siRNA as therapeutics for SARS-CoV-2 infection