Therapeutics News and Research

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Combination of REGN910 and aflibercept inhibits tumor angiogenesis in animal models

Combining the investigational agents REGN910 and aflibercept yielded statistically significant improvements in antitumor effects in animal models compared with either agent alone, according to results presented at the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, held Nov. 12-16, 2011.

14 Nov 2011

Amplification of ALK gene may drive rapid breast cancer metastasis

Amplification of anaplastic lymphoma kinase, which has been reported in other cancers such as non-small cell lung cancers, may be a primary driver of the rapid metastasis that patients with inflammatory breast cancer experience.

14 Nov 2011

Researchers show how ER-positive breast cancer tumors become resistant to tamoxifen

Researchers have shown how estrogen receptor-positive breast cancer tumors become resistant to tamoxifen, the only approved hormonal therapy for premenopausal patients with this type of breast cancer.

14 Nov 2011

Exelixis reports cabozantinib phase 2 trial data on bone metastases

Exelixis, Inc. today reported interim data on pain relief and related reduction in narcotic analgesic use with cabozantinib in castration-resistant prostate cancer (CRPC) patients with bone metastases.

14 Nov 2011

New data on TetraLogic's TL32711 cancer drug to be presented at AACR-NCI-EORTC conference

TetraLogic Pharmaceuticals, a biopharmaceutical company developing novel small molecule Smac mimetic drugs to treat cancer, today announced presentations of new data on its Smac mimetic drug candidate TL32711 at the 2011 AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics in San Francisco.

14 Nov 2011

Patients with KRAS mutant NSCLC should respond well to antifolates

Patients with non-small cell lung cancer who have mutations in the KRAS gene should respond well to the antifolate class of drugs, according to results of a recent study conducted by Quintiles comparing human lung cancer cell lines and patients.

14 Nov 2011

Renowned cardiologist wins TCT 2011 Geoffrey O. Hartzler Master Clinical Operator Award

Horst Sievert, MD, PhD, a renowned interventional cardiologist, was presented the TCT 2011 Geoffrey O. Hartzler Master Clinical Operator Award in a ceremony held today during the 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation.

14 Nov 2011

NovaUCD to showcase 15 new high-tech ventures at annual start-up awards

NovaUCD will showcase 15 new high-tech and knowledge-intensive ventures emerging from University College Dublin (UCD) research programmes during its annual start-up awards evening next week.

13 Nov 2011

NeoStem third quarter revenues increase to $17.8 million

NeoStem, Inc., an international biopharmaceutical company with a focus on cell based therapeutics development, today reported third quarter results and recent progress in its business.

11 Nov 2011

Elixir Medical announces initiation of DESolve Novolimus Eluting Bioresorbable Coronary Scaffold System study

Elixir Medical Corporation, a developer of products that combine state-of-the-art medical devices with advanced pharmaceuticals, announced enrollment initiation for a 120-patient, international pivotal clinical study to evaluate the safety and efficacy of the DESolve Novolimus Eluting Bioresorbable Coronary Scaffold System designed to resorb in the body within 1 to 2 years after implantation and return the patients' coronary vessel to de novo state.

11 Nov 2011

Worm model to evaluate drugs for Parkinson's disease

Researchers at The University of Texas at Austin have devised a simple test, using dopamine-deficient worms, for identifying drugs that may help people with Parkinson's disease.

11 Nov 2011

Study examines potential cost effectiveness of TAVR versus SAVR

The cost effectiveness of transcatheter aortic valve implantation (TAVR) compared to surgical aortic valve replacement (SAVR) depends on whether TAVR is performed via the femoral artery or transapically, through a small incision in the chest, according to a new study.

11 Nov 2011

Drug effectively combats obesity in “couch potato” monkeys” Study

According a new study an experimental anti-cancer drug could help fight obesity. The drug chokes off the blood supply to fat cells and helped obese monkeys slim down in the experiments.

10 Nov 2011

Positive results from BIOTRONIK Pantera Lux Paclitaxel Releasing Balloon study presented at TCT 2011

Six-month results from the DELUX registry and 12-month results from the PEPPER study, both demonstrating excellent safety and efficacy results for the Pantera Lux Paclitaxel Releasing Balloon, were presented on Tuesday and Wednesday at the Transcatheter Cardiovascular Therapeutics (TCT 2011) conference by Dr. Ralph Toelg, MD, Segeberger Heart Center Clinic, Bad Segeberg, Germany, and Prof. Christoph Hehrlein, MD, University Medical Center, Freiburg, Germany, respectively.

10 Nov 2011

CCCBD scientist to receive 2011 V Foundation Translational Research Grant

Scientists at the Children's Center for Cancer and Blood Diseases (CCCBD) and the Keck School of Medicine of the University of Southern California, have been awarded a highly competitive translational research grant of $600,000 from The V Foundation for Cancer Research.

10 Nov 2011

Tailored anti-platelet therapy optimizes treatment for patients wtih common genetic variant

Tailored anti-platelet therapy, made possible through a novel point-of-care genetic test, optimizes treatment for patients who carry a common genetic variant, researchers at the University of Ottawa Heart Institute (UOHI) have found.

10 Nov 2011

World-renowned cardiologist receives 2011 TCT Career Achievement Award

Eric J. Topol, MD, a world-renowned cardiologist and physician-scientist, was presented the 2011 TCT Career Achievement Award in a ceremony held today during the 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation.

10 Nov 2011

Positive results from InSeal's intravascular large bore puncture closure device trial

InSeal Medical Ltd., developer of percutaneous vascular closure devices for large bore punctures, today announced the successful treatment of three patients with its investigational intravascular large bore puncture closure device.

10 Nov 2011

Carotid artery stenting could treat severe disease lesions

Patients who are not candidates for traditional surgery for severe carotid artery disease lesions could be treated with carotid artery stenting, according to results of a small feasibility study by cardiologists at The University of Texas Health Science Center at Houston.

9 Nov 2011

Salix to acquire Oceana Therapeutics

Oceana Therapeutics LLC, a privately owned global company focused on commercializing best-in-class specialty therapeutics, today announced it has entered into a definitive agreement for the sale of its operating subsidiary, Oceana Therapeutics, Inc. to Salix Pharmaceuticals, Ltd. of Raleigh, NC.

9 Nov 2011

Therapeutics News and Research

Combination of REGN910 and aflibercept inhibits tumor angiogenesis in animal models

Amplification of ALK gene may drive rapid breast cancer metastasis

Researchers show how ER-positive breast cancer tumors become resistant to tamoxifen

Exelixis reports cabozantinib phase 2 trial data on bone metastases

New data on TetraLogic's TL32711 cancer drug to be presented at AACR-NCI-EORTC conference

Patients with KRAS mutant NSCLC should respond well to antifolates

Renowned cardiologist wins TCT 2011 Geoffrey O. Hartzler Master Clinical Operator Award

NovaUCD to showcase 15 new high-tech ventures at annual start-up awards

NeoStem third quarter revenues increase to $17.8 million

Elixir Medical announces initiation of DESolve Novolimus Eluting Bioresorbable Coronary Scaffold System study

Worm model to evaluate drugs for Parkinson's disease

Study examines potential cost effectiveness of TAVR versus SAVR

Drug effectively combats obesity in “couch potato” monkeys” Study

Positive results from BIOTRONIK Pantera Lux Paclitaxel Releasing Balloon study presented at TCT 2011

CCCBD scientist to receive 2011 V Foundation Translational Research Grant

Tailored anti-platelet therapy optimizes treatment for patients wtih common genetic variant

World-renowned cardiologist receives 2011 TCT Career Achievement Award

Positive results from InSeal's intravascular large bore puncture closure device trial

Carotid artery stenting could treat severe disease lesions

Salix to acquire Oceana Therapeutics

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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