Hysitron® BioSoft™ In-Situ Indenter from Bruker Nano Surfaces

Bruker’s   Hysitron®   BioSoft™   In-Situ   Indenter is a first-of-its-kind instrument specifically designed  for  multiscale  quantitative mechanical  testing  of  biological  materials  and soft matter, such as hydrogels. BioSoft synchronizes   powerful   mechanical and optical characterization techniques to achieve a comprehensive understanding of the mechanics  of  biomaterials. This portable system integrates with existing inverted optical microscopes to bring advanced biomechanical testing capabilities into your laboratory.

Maximized Test Flexibility

  • Integrates with inverted microscopes to characterize a broad range of biological materials
  • Easily transports into any laboratory with the included watertight carrying case
  • Enables biomechanical testing while maintaining the capability to perform complex experiments with simple operation and multi-user software
  • Achieves results quickly with easy changing between a wide variety of probes in under a minute

1 mm spherical probe in contact with osteoblast cell.

1 mm spherical probe in contact with osteoblast cell. Courtesy of Bruker Nano Surfaces.

Quantitative Soft Biomaterials Characterization

Incorporating decades of knowledge in soft matter testing, Bruker’s Hysitron BioSoft provides a unique combination of force sensitivity and displacement range to provide quantitative mechanical property measurements on sub-cellular to tissue levels. Streamlined system operation delivers the results you need quickly, minimizing the need to become an experimental expert and providing an easy portal to biomechanical characterization.

ioSoft In-Situ Indenter Features

  • Quantitative mechanical characterization for your optical microscope
  • Seamless integration with inverted microscopes for maximum test flexibility
  • Synchronized mechanical and optical characterization techniques
  • Characterization of specimens on sub-cellular to tissue levels
  • In-situ observation during mechanical testing
  • Advanced targeting and precision
  • Access to physiological pressures from Pa to kPa
  • Open platform for testing in fluid and environmental control
  • Customizable probes


Normal Loading (Quasi-static Testing)

Maximum Force: 10 mN Load Noise Floor: <750 nN

Normal Force Bit Resolution: 1 nN


Normal Displacement (Quasi-static Testing)

Maximum Displacement: 150 µm Displacement Noise Floor: <1 nm

Normal Displacement Bit Resolution: 0.006 nm Thermal Drift of Sensor: ≤0.05 nm/sec

BioMech Control Module Specifications

Maximum Data Acquisition Rate

96 kHz

Maximum Data Sampling Rate

48 kHz

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