Bruker launches innovative iProbe HRMAS for biomolecular, materials and clinical research

At EUROMAR 2018 conference (www.euromar2018.org), Bruker announced the iProbe™ HRMAS, which now enables full automation of high-resolution magic angle spinning (HRMAS) NMR. Built on the recently introduced iProbe platform, the new HRMAS technology offers for the first time all benefits of automated tuning and matching for all RF-channels, together with accurate automated adjustment of the magic angle position. The automatic sample exchange capabilities of the iProbe HRMAS enable simplified sample handling and experiment optimization, leading to higher reproducibility and productivity in academic, industrial and clinical research.

Similar to liquid NMR, the new iProbe HRMAS provides automatic sample insertion and ejection from the top of the magnet. Automated tuning and matching is performed with the enhanced, 2nd generation ATMA using cartesian coordinates-based algorithms, while the adjustment of the magic angle outperforms the precision and reproducibility of manual optimization.

In combination with Bruker's sample changer line SamplePro™, and routine IconNMR™ acquisition software and TopSolids analysis software, HRMAS NMR spectroscopy now becomes suitable for applied markets, such as metabolic profiling of human tissues, as well as novice HRMAS users in research. The iProbe HRMAS is available for 400, 500 and 600 MHz standard bore magnets.

Falko Busse, Ph.D., President of the Bruker BioSpin Group, stated:

Bruker is very committed to provide our scientific and industrial customers tools for maximum scientific productivity. The forward-thinking architecture behind the iProbe HRMAS concept allows basic research as well as applied science customers the efficient implementation of leading-edge HRMAS experiments, with even better performance, ease of use and stability."

Bruker also presents other novel magnetic resonance based tools for chemistry, biomolecular and material science research at EUROMAR 2018: The Biosolids CryoProbe™ is the latest technology introduction of the high-sensitivity CryoProbe series. Biosolids CryoProbes now allow the investigation of various biological solids, such as membrane proteins or disease aggregates at physiological temperatures, with a three-fold boost in sensitivity. After the extremely successful adoption of cryogenically cooled NMR probes for liquids NMR and MR imaging, the Biosolids CryoProbe represents the 3rd frontier for this breakthrough technology. The probes, designed for standard-bore magnets, are compatible with the CryoPlatform™. They can reach magic angle spinning (MAS) rates of up to 20 kHz.

Bruker's line of Dynamic Nuclear Polarization (DNP) NMR systems has now expanded to include a 263 GHz klystron microwave source for DNP NMR for materials research at 400 MHz, and a 593 GHz gyrotron microwave source for high-field 900 MHz DNP NMR for biological research. The 263 GHz klystron offers DNP at lower cost, and with reduced footprint and facility requirements. Bruker delivered the first 593 GHz DNP system in October 2017 to EPFL in Lausanne, Switzerland. Development included a new gyrotron tube design for 593 GHz, using a 11.7 T gyrotron magnet, custom microwave transmission line, and new 900 MHz low-temperature MAS DNP probes.

The compact AVANCE™ NEO NanoBay now extends the successful line of NEO consoles with dual-channel transmit & dual receive capabilities to routine 300 and 400 MHz NMR. With the novel NEO 'transceiver' architecture, each NMR channel in the AVANCE NEO is a functional spectrometer, thereby enabling a new generation of multi-receive experiments. The small footprint NanoBay supports a wide range of applications, including chemistry research and analysis, high-throughput screening for applied markets and quality control, and to structure verification in drug discovery.

A novel 1.0 GHz NMR TXO CryoProbe™ now also permits 15N direct detection on GigaHertz NMR spectrometers. Prof. Haribabu Arthanari of the Dana-Farber Cancer Institute at Harvard Medical School stated:

New CryoProbes coupled with novel NMR methods that harness the slow relaxation advantages of low-gamma nuclei (15N & 13C) offer great promise for investigating even larger molecular weight proteins and IDPs by NMR. Acquiring high sensitivity 15N detection data on 1.0 GHz NMR is a great opportunity to further enable the investigation of critical interactions between transcription factors and the general transcriptional machinery, and to decipher the secrets of the disordered part of the human proteome sometimes referred to as the 'Dark Proteome'."

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