iQue® Poster Presentation Snapshots: Advanced Flow Cytometry, Quantifying in vitro Complement-Dependent Cytotoxicity


In recent decades, rapid progression of monoclonal antibody (mAb) development has culminated in approvals for more than one hundred therapeutics in the United States. 

mAbs enhance the immune response through three key Fc-mediated functions: antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP) and complement-dependent cytotoxicity (CDC). 

CDC is initiated when a mAb triggers activation of the complement cascade, which ultimately results in tumor cell lysis.

This poster video presents a simple, high-throughput, miniaturized assay for measuring CDC, using the iQue® Advanced Flow Cytometry Platform, with its integrated iQue Forecyt® software.  Thus streamlining antibody characterization and drug discovery processes.

Quantifying in vitro Complement-Dependent Cytotoxicity (CDC) using Advanced Flow Cytometry Video | Sartorius

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