The Cohort of Concern in Toxicology Testing

The Cohort of Concern in Toxicology Testing

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Toxicological risk assessments commonly aim to identify non-harmful levels of human exposure to specific compounds and chemicals. These chemicals can be investigated at lower levels than ever before with the increase of accurate testing techniques available in analytical chemistry.

Research has shown that unstudied substances can be found in food products, drinking water, and even in the human body. Discriminating between chemicals that require immediate additional research and those that show no tangible risk to human health is required to understand the possible health effects of these varying chemicals.

The Threshold of Toxicological Concern (TTC) is a term given to the degree of human exposure to any non-harmful chemical.

This beneficial technique identifies a safe range for any unstudied chemical discounting any missing toxicology information. The aim of the TTC is to prioritize specific structural groups with higher mutagenic potencies, which pose greater health risks to humans.

The whitepaper Cohort of Concern outlines a group of compounds that are higher than the potency detailed in the TTC. Known as the cohort of concern (CoC), this group is of specific interest to toxicology testing because of their high-carcinogenic and toxicogenic features.

Toxicology services from Jordi Labs

Jordi Labs is a pioneering service supplier for regulatory research. A wide range of toxicology services are provided to assist in regulatory compliance, or to help with the initial assessment of compounds and chemicals of interest in the product.

To learn more, simply contact a member of the Jordi Labs team today.

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About Jordi Labs

Jordi Labs provides the highest quality contract analytical services and polymer HPLC columns to some of the world’s leading consumer products, polymers, pharmaceutical and medical device manufacturers. Our team of PhD analytical chemists specialize in chemical identification. One of core competencies is Extractables & Leachables testing.

We are also worldwide leaders in;

  • Particulates & residue analysis
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  • Polymer failure

We also help companies from Fortune 500s to innovative startups with method development, preparative HPLC, training seminars, depositions and consulting. As a family company, we take pride in the production of all of our products and analytical service offerings. It is our goal to help our customers overcome their analytical challenges by providing excellent products and personal assistance from our highly-trained staff of PhD chemists.

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Last updated: Oct 1, 2020 at 5:10 AM


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