Syndrome News and Research

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Longer looks: Romney and abortion politics

The heart attacks never came. Four days later, Chris woke up. It was not the awakening of Hollywood movies in which the patient comes to, just as he was, speaking full sentences and completely mobile. Three years later, Chris still cannot talk. Although he breathes on his own, his lungs battle a steady barrage of infections; a feeding tube provides all his sustenance, and his muscles have contracted into short, twisted knots. He can move only the slightest bit. … Still, Wayne and Judy say that his cognition is improving.

9 Dec 2011

Recommendations to address challenges associated with chronic inflammatory diseases

A dramatic increase in the incidence of chronic inflammatory diseases such as asthma, allergy, and irritable bowel syndrome, has led to concern about how modern lifestyles may trigger physiological defense mechanisms.

8 Dec 2011

Massive and consistent changes in inflammatory gene expression seen in trauma, burns

Serious traumatic injuries, including major burns, set off a "genomic storm" in human immune cells, altering around 80 percent of the cells' normal gene expression patterns. In a report to appear in the December Journal of Experimental Medicine, members of a nationwide research collaborative describe the initial results of their investigation into the immune system response to serious injury, findings which have overturned some longstanding assumptions.

8 Dec 2011

Donated permanent pacemakers safe and effective for Indian heart patients

Many heart patients in India are too poor to afford pacemakers. But a study has found that removing pacemakers from deceased Americans, resterilizing the devices and implanting them in Indian patients "is very safe and effective."

From Medtronic 7 Dec 2011

Testing athletes for concussions may induce mental fatigue

Testing athletes for concussions may induce mental fatigue in subjects whether or not they have a head injury, according to Penn State researchers.

7 Dec 2011

INT-777 shows promise against metabolic syndrome

Heart disease is a major cause of death in industrialised countries, and is strongly associated with obesity and diabetes. Many scientists believe that what links these conditions is a chronic, low-grade inflammation.

7 Dec 2011

Fatty livers burn more fat, not less

When our livers become loaded with fat, it isn't because they are slacking. A new study of human patients in the December Cell Metabolism shows that fatty livers actually burn more fat, not less. All that "hard work" may be at the root of the organ damage that comes with nonalcoholic fatty liver disease (NAFLD), a condition associated with insulin resistance that affects about one in three in the U.S. population.

6 Dec 2011

EnVivo presents positive EVP-6124 Phase 2b trial data on schizophrenia at 50th ACNP meeting

EnVivo Pharmaceuticals, a company dedicated to developing a broad range of novel central nervous system (CNS) therapies, announced today that it is presenting the comprehensive analysis of a recently completed Phase 2b clinical trial of EVP-6124, a novel, orally bioavailable nicotinic alpha-7 agonist, in schizophrenia at the American College of Neuropsychopharmacology 50th Anniversary Annual Meeting.

5 Dec 2011

Factors associated with increased risk of in-hospital falls after total hip or knee replacement surgery

Investigators from Hospital for Special Surgery have identified factors that are associated with an increased risk of in-hospital falls after total hip or knee replacement surgery.

5 Dec 2011

The head plays key role in tiring endurance performances

Researchers from the University of Zurich have now studied in detail what sportsmen and women know from experience: The head plays a key role in tiring endurance performances.

5 Dec 2011

Moffitt investigators to participate with 16 oral and 50 posters presentations at 53rd ASH meeting

When the American Society of Hematology convenes its 53rd Annual Meeting and Exposition on Dec. 10-13 in San Diego, Calif., researchers from Moffitt Cancer Center will break a new record for Moffitt participants with one plenary presentation, 16 oral presentations and more than 50 poster presentations on new research results in a variety of meeting programs that focus on blood cancer basic science and clinical applications, including bone marrow transplantation and clinical trials results.

5 Dec 2011

Scientists discover new candidate gene for Dravet syndrome

Dravet syndrome is a severe genetic epilepsy that appears early in life. About 75 percent of cases can be attributed to mutations in the SCN1A gene encoding the sodium channel NaV1.1. The remaining patients with this syndrome are without a definitive molecular genetic diagnosis. Research presented today at the American Epilepsy Society's 65th Annual Meeting has found a non-SCN1A candidate gene and suggests that Dravet syndrome may be caused by any one of a number of yet unidentified genes.

5 Dec 2011

U-M scientists generate Dravet-derived neurons

Scientists investigating the fundamental cause of Dravet syndrome, a severe childhood epilepsy, have reprogrammed fibroblasts, a type of skin cell, from Dravet patients and generated patient-specific neurons.

5 Dec 2011

Bromide shows promise against SCN1A-associated Dravet syndrome with intractable seizures

In the mid-nineteenth century Charles Locock, physician to Queen Victoria, introduced bromide as the first effective treatment for epilepsy. The drug was little used in treating the disorder until 1868, however, when its efficacy against seizures was first demonstrated in a clinical trial. Bromide was the sole anticonvulsant available until 1912 and the introduction of phenobarbital.

5 Dec 2011

Novartis to showcase 160 presentations on breast cancer, hematological disease drugs at SABCS and ASH

Novartis Pharmaceuticals Corporation will showcase more than one hundred and sixty presentations on data from its robust oncology portfolio at two key medical congresses this month, demonstrating significant advances for patients with cancers and hematological diseases.

3 Dec 2011

World Cell Race pulls 70 entries for title of world's fastest cell

A "team" of fast-moving, bone marrow stem cells from a research laboratory in Singapore has run away with the first World Cell Race, finishing first with a cellular speed record of 5.2 microns per minute (or 0.000204 inches per minute) in results announced today at the 51st Annual Meeting of the American Society for Cell Biology (ASCB).

3 Dec 2011

Longer looks: Life of a Medicare demo project; Broken hearts; AIDS funding

Today's Medicare demonstration project might determine how physicians interact with the program tomorrow, so naturally such projects generate a lot of buzz in the health care community. Lately, some of that buzz has been about how demos might provide part of the solution for Medicare's payment problems.

2 Dec 2011

ASH recognizes abstract presenters at 53rd annual meeting in San Diego

The American Society of Hematology (ASH) recognizes the following abstract presenters at the 53rd ASH annual meeting in San Diego, CA, with the highest scoring abstracts in the categories of undergraduate student, medical student, graduate student, resident physician, and postdoctoral fellow.

2 Dec 2011

Einstein, Montefiore receive NINDS grant to establish clinical site for NeuroNEXT

In a development that could pave the way for treatment for rare neurological diseases and clues to more common ones, physician-scientists at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center, the University Hospital for Einstein, have secured a grant to establish a clinical site for the Network for Excellence in Neuroscience Clinical Trials.

2 Dec 2011

Burnout should be regarded as a risk factor for depressive disorders

In the media, burnout is a topic covered with repetitive regularity. In spite of this, no agreed definition exists, and neither does a valid instrument to diagnose burnout syndrome.

2 Dec 2011

Syndrome News and Research

Longer looks: Romney and abortion politics

Recommendations to address challenges associated with chronic inflammatory diseases

Massive and consistent changes in inflammatory gene expression seen in trauma, burns

Donated permanent pacemakers safe and effective for Indian heart patients

Testing athletes for concussions may induce mental fatigue

INT-777 shows promise against metabolic syndrome

Fatty livers burn more fat, not less

EnVivo presents positive EVP-6124 Phase 2b trial data on schizophrenia at 50th ACNP meeting

Factors associated with increased risk of in-hospital falls after total hip or knee replacement surgery

The head plays key role in tiring endurance performances

Moffitt investigators to participate with 16 oral and 50 posters presentations at 53rd ASH meeting

Scientists discover new candidate gene for Dravet syndrome

U-M scientists generate Dravet-derived neurons

Bromide shows promise against SCN1A-associated Dravet syndrome with intractable seizures

Novartis to showcase 160 presentations on breast cancer, hematological disease drugs at SABCS and ASH

World Cell Race pulls 70 entries for title of world's fastest cell

Longer looks: Life of a Medicare demo project; Broken hearts; AIDS funding

ASH recognizes abstract presenters at 53rd annual meeting in San Diego

Einstein, Montefiore receive NINDS grant to establish clinical site for NeuroNEXT

Burnout should be regarded as a risk factor for depressive disorders

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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