Syndrome News and Research

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Investigation finds 'disarray' in institutions for housing developmentally disabled

O. D. Heck is one of nine large institutions in New York that house the developmentally disabled, those with cerebral palsy, autism, Down syndrome and other conditions.

6 Jun 2011

First Edition: June 6, 2011

Kaiser Health News staff writer Christopher Weaver reports: "Short on cash and time, officials in California and at least a dozen other states have turned to philanthropies to help pay for the extra work required under the federal health law".

6 Jun 2011

Cancer risk assessment in Lynch syndrome

Among various genetic mutations for individuals with Lynch syndrome, a hereditary cancer syndrome that carries a high risk of colon cancer and an above-normal risk of other cancers, researchers have identified mutations associated with a lower cancer risk and mutations associated with an increased risk for ovarian and endometrial cancer, according to a study in the June 8 issue of JAMA, a theme issue on cancer.

6 Jun 2011

Androgen deprivation therapy may increase risk of diabetes in men with prostate cancer

Men with prostate cancer are at higher risk of developing diabetes or diabetes risk factors if they receive androgen deprivation therapy (ADT) to block the production or action of male hormones that can fuel the growth of this cancer.

6 Jun 2011

Denali, Can-Fite sign agreement to conclude ophthalmology spinoff

Can-Fite BioPharma Ltd, a biotechnology company developing small molecule drugs for the treatment of inflammatory, ophthalmic, and liver diseases, traded on the Tel Aviv Stock Exchange, signed today an agreement to spin off its ophthalmic indications to a US based public company, Denali Concrete Management Inc.

6 Jun 2011

Interim results from CTI, Chroma Therapeutics' tosedostat phase II trial on AML presented at ASCO

Cell Therapeutics, Inc. and Chroma Therapeutics Ltd. announced that interim results from the phase II OPAL study of tosedostat in elderly patients with relapsed or refractory acute myeloid leukemia (AML) were presented by Jorge Cortes, M.D. and discussed at the 2011 Annual Meeting of the American Society of Clinical Oncology (ASCO) by Farhad Ravandi, M.D., who presided over the ASCO discussion session, both of the University of Texas M.D. Anderson Cancer Center.

6 Jun 2011

Promising results from Exelixis' cabozantinib phase 2 trial against metastatic ovarian cancer

Exelixis, Inc. reported longer follow-up data from a fully enrolled cohort of patients with advanced epithelial ovarian cancer, primary peritoneal carcinoma, or fallopian tube carcinoma treated with cabozantinib (XL184) in an ongoing phase 2 adaptive randomized discontinuation trial. Cabozantinib shows promising activity in these patients independent of prior response to platinum-based therapies.

6 Jun 2011

New E. coli outbreak alarms Europe

An Escherichia coli (E. coli) outbreak of disease in Germany has left 22 people dead and it is alarming populations across Europe.

5 Jun 2011

Preliminary data from Ion PGM sequencer reveals German E. coli outbreak is a new hybrid strain

Life Technologies Corporation today announced that preliminary data from DNA sequencing performed in cooperation with the University Hospital Muenster, Germany, on the Ion Personal Genome Machine strongly suggests that the bacterium at the root of the deadly outbreak in Germany is a new hybrid type of pathogenic E. coli strains.

4 Jun 2011

BGI genome sequencing identifies new super-toxic bacteria as cause of current European epidemic

The recent outbreak of an E. coli infection in Germany has resulted in serious concerns about the potential appearance of a new deadly strain of bacteria.

4 Jun 2011

Scientists identify chromosomal mutation responsible for excessive hair growth

Researchers in the Keck School of Medicine of the University of Southern California (USC), together with scientists in Beijing, China, have discovered a chromosomal mutation responsible for a very rare condition in which people grow excess hair all over their bodies.

4 Jun 2011

European E. coli strain never seen before in humans, scientists say

The food safety office of the WHO on Thursday announced that the bacterium responsible for the E. coli outbreak in Europe is a strain never seen before in humans and could mean "the infection could prove unusually difficult to bring under control," Nature News reports.

4 Jun 2011

Cancer vaccine shows improved response rate in patients

A vaccine for one of the most lethal cancers, advanced melanoma, has improved response rate and progression-free survival for patients when combined with the immunotherapy drug Interleukin-2, according to research led by scientists from The University of Texas MD Anderson Cancer Center and Indiana University Health Goshen Center for Cancer Care.

3 Jun 2011

Preclinical study: Combination therapy of SPX-106 and D-tagatose reduces triglycerides and cholesterol

Spherix Incorporated, an innovator in biotechnology for therapy in diabetes, metabolic syndrome and atherosclerosis, and providers of technical and regulatory consulting services to food, supplement, biotechnology and pharmaceutical companies, today announced that its drug candidate, SPX-106, achieved statistically significant reductions in triglycerides and cholesterol when administered in combination with D-tagatose for nine weeks to genetically engineered mice prone to dyslipidemia.

3 Jun 2011

E coli outbreak in Germany continues

As the current virulent Shiga toxin-producing Escherichia coli (STEC) outbreak in Germany spreads, experts from The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) are concerned not only about the pressure health facilities are being put under, but also the use of antibiotics and broader implications for preparedness across Europe to cope, both now and in the future.

3 Jun 2011

'Switching off' critical disease causing gene can reestablish Rett syndrome in adult animals

An IRSF funded study published today in the journal Science has shown that the childhood disorder Rett syndrome, can be reestablished in adult animals by "switching off" a critical disease causing gene in healthy adult animals.

3 Jun 2011

Teva completes patient enrollment in COPAXONE Phase III trial for treatment of multiple sclerosis

Teva Pharmaceutical Industries Ltd. today announced completion of patient enrollment for the GALA (Glatiramer Acetate Low-frequency Administration) trial.

3 Jun 2011

Scientists identify protein sorting mechanism used by salivary gland

University of Louisville researchers are one step closer to helping millions of people whose salivary glands no longer work because of disease or damage from treatment of diseases.

3 Jun 2011

Seaside Therapeutics commences STX209 Phase 3 study in fragile X syndrome

Seaside Therapeutics, Inc. announced today the initiation of a randomized, double-blind, placebo-controlled Phase 3 study to evaluate the effects of STX209 on social impairment in adolescents and adults with fragile X syndrome.

2 Jun 2011

Final analysis of AVEO's tivozanib Phase 2 trial on kidney cancer patients presented at ASCO 2011

AVEO Pharmaceuticals, Inc., today announced data from the final analysis of its Phase 2 randomized discontinuation trial evaluating tivozanib, its lead product candidate designed to optimally block the VEGF pathway by inhibiting all three VEGF receptors, in patients with advanced renal cell carcinoma.

2 Jun 2011

Syndrome News and Research

Investigation finds 'disarray' in institutions for housing developmentally disabled

First Edition: June 6, 2011

Cancer risk assessment in Lynch syndrome

Androgen deprivation therapy may increase risk of diabetes in men with prostate cancer

Denali, Can-Fite sign agreement to conclude ophthalmology spinoff

Interim results from CTI, Chroma Therapeutics' tosedostat phase II trial on AML presented at ASCO

Promising results from Exelixis' cabozantinib phase 2 trial against metastatic ovarian cancer

New E. coli outbreak alarms Europe

Preliminary data from Ion PGM sequencer reveals German E. coli outbreak is a new hybrid strain

BGI genome sequencing identifies new super-toxic bacteria as cause of current European epidemic

Scientists identify chromosomal mutation responsible for excessive hair growth

European E. coli strain never seen before in humans, scientists say

Cancer vaccine shows improved response rate in patients

Preclinical study: Combination therapy of SPX-106 and D-tagatose reduces triglycerides and cholesterol

E coli outbreak in Germany continues

'Switching off' critical disease causing gene can reestablish Rett syndrome in adult animals

Teva completes patient enrollment in COPAXONE Phase III trial for treatment of multiple sclerosis

Scientists identify protein sorting mechanism used by salivary gland

Seaside Therapeutics commences STX209 Phase 3 study in fragile X syndrome

Final analysis of AVEO's tivozanib Phase 2 trial on kidney cancer patients presented at ASCO 2011

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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