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Study finds association between ERBB4 gene, LVOT malformations

A gene known to be important in cardiac development has been newly associated with congenital heart malformations that result in obstruction of the left ventricular outflow tract. These are the findings from a study conducted by Nationwide Children's Hospital and appearing in the journal Birth Defects Research Part A.

30 Apr 2011

Scientists develop novel genetic model of premature aging disorders

Working with a group of national and international researchers, scientists from the Florida campus of The Scripps Research Institute have developed a new genetic model of premature aging disorders that could shed light on these rare conditions in humans and provide a novel platform for large-scale screening of compounds to combat these and other age-related diseases.

29 Apr 2011

Curis reports first quarter net loss of $6.8 million

Curis, Inc., a drug development company seeking to develop next generation targeted small molecule drug candidates for cancer treatment, today reported its financial results for the first quarter ended March 31, 2011.

28 Apr 2011

New microchip sensor can detect individual's respiratory rate

Researchers at Tyndall National Institute, UCC, Cork, have developed a microchip sensor that can detect a person's respiratory rate without any contact with the person under observation.

28 Apr 2011

Study finds increase in implementation of evidence-based therapies for myocardial infarction

In an analysis of data from a coronary care registry in Sweden, between 1996-2007 there was an increase in the prevalence of use of evidence-based invasive procedures and pharmacological therapies for treatment of a certain type of heart attack, and a decrease in the rate of death at 30 days and one year after a heart attack for these patients, according to a study in the April 27 issue of JAMA.

28 Apr 2011

Positive results from Shire's Vyvanse clinical trial in schizophrenia

Shire plc, the global specialty biopharmaceutical company, today announced positive results from a signal-finding study of Vyvanse(R) Capsules assessing its effect in a prospective examination of adults with negative symptom predominant schizophrenia.

28 Apr 2011

GSN receives NIH grant for non-invasive prenatal test trial in genetic abnormalities

Gene Security Network announced today that they have received a $2 million grant from the National Institutes of Health to conduct a clinical trial applying Parental Support technology for non-invasive prenatal diagnosis.

28 Apr 2011

New control point for suppressing cancer cell growth

Dana-Farber Cancer Institute scientists have discovered new details of how cancer cells escape from tumor suppression mechanisms that normally prevent these damaged cells from multiplying. They also demonstrated a potential link between this cell proliferation control mechanism and the cognitive deficits caused by Down syndrome.

28 Apr 2011

Researchers begin approved drugs screening for clinical use against rare diseases

Researchers have begun screening the first definitive collection of thousands of approved drugs for clinical use against rare and neglected diseases. They are hunting for additional uses of the drugs hoping to find off-label therapies, for some of the 6,000 rare diseases that afflict 25 million Americans.

28 Apr 2011

GPs could offer simple test for early detection of ovarian cancer

Health experts have said that hundreds of lives could be saved a year if GPs were quicker to spot symptoms of the disease - dubbed a “silent killer” because it is hard to diagnose early enough. Ovarian cancer kills almost 4,400 women in Britain every year. It kills one every two hours that makes it the fourth most common cancer in females. While almost three times as many die from breast cancer, those diagnosed with ovarian cancer are far more likely to die earlier.

28 Apr 2011

Novel strategy for physicians to detect Autism Syndrome Disorder in babies

A novel strategy developed by autism researchers at the University of California, San Diego School of Medicine, called "The One-Year Well-Baby Check Up Approach," shows promise as a simple way for physicians to detect cases of Autism Syndrome Disorder, language or developmental delays in babies at an early age.

28 Apr 2011

Tips for parents to identify concussions in young athletes

A recent study found that many parents feel they lack the knowledge to adequately detect symptoms of head injuries in their children. Yet keeping young athletes off the field until they've fully healed from a concussion is key to preventing serious and potentially fatal complications.

27 Apr 2011

Blueberries may help fight obesity

Recently a study out of the Texas Women's University looked at whether blueberries with their high polyphenol content could help in fighting obesity. Blueberries after all have already been cited as having positive health effects on other conditions like cardiovascular disease and metabolic syndrome. The study was conducted in Petri dishes (not live animals) using a blueberry polyphenol extract and tissue cultures from mice.

27 Apr 2011

Colorectal cancer patients with genetic mutation can benefit from new class of drugs

A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.

26 Apr 2011

Researchers discover molecular mechanisms behind autoimmunity

Researchers from Boston University School of Medicine have discovered that human proteins with an affinity for Dermatan Sulfate have the propensity to become autoantigens. In a companion article, the researchers also found that DS physically interacts with dead cells and that the resulting DS-autoantigen complexes drive autoreactive B-1a cell responses and autoantibody production both in-vitro and in mouse models.

26 Apr 2011

Kadmon Pharmaceuticals and Nano Terra announce worldwide licensing agreement

Kadmon Pharmaceuticals LLC, and Nano Terra, Inc., today announced that they have entered into an agreement under which Kadmon has been granted a perpetual, worldwide exclusive license to three novel, clinical-stage product candidates owned by Nano Terra as well as rights to Nano Terra’s drug discovery platform, Pharmacomer™ Technology. The product candidates and technology platform will be transferred to a newly formed joint venture, NT Life Sciences (“NT Life”), co-owned by Kadmon and Nano Terra, which will act as the licensor and recipient of any licensing or royalty fees subject to the agreement. Terms of the agreement were not disclosed.

25 Apr 2011

New research provides insight into mechanism behind cardiac development

During embryonic development, cells migrate to their eventual location in the adult body plan and begin to differentiate into specific cell types. Thanks to new research at the University of Pennsylvania, there is new insight into how these processes regulate tissues formation in the heart.

25 Apr 2011

Symposium to explore energy balance in physiologically maladaptive Homo sapiens

In the human body, an incessant competition is raging between energy storing-anabolic-processes and the less abundant energy using-catabolic-processes. In most people, energy balance varies within a narrow range.

25 Apr 2011

Nano Terra, Kadmon sign deal to license novel product candidates

25 Apr 2011

Cardiologist pioneers new test to detect sudden death syndrome in young athletes

When a high school athlete drops dead, the rare but fatal condition called "sudden death syndrome" dominates the headlines. For reasons that remain a mystery to scientists, some young athletes - especially young males - begin to experience an unusual heart arrhythmia. With over-exertion, their hearts stop pumping, leading to sudden death.

22 Apr 2011