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First comprehensive, international baseline evidence about pandemics published

Public health officials walking a tightrope between massive demand for vaccines and intense public scrutiny of side effects now have a new standard for evaluating the safety of their vaccination programs.

19 Nov 2009

Astellas Pharma and XenoPort submit NDA in Japan for PMDA approval

Astellas Pharma Inc. and XenoPort, Inc. today announced that a new drug application (NDA) has been filed with the Pharmaceuticals and Medical Device Agency (PMDA) in Japan for ASP8825 (gabapentin enacarbil), also known as XP13512, as a potential treatment for restless legs syndrome (RLS).

19 Nov 2009

Microarray analysis can identify chromosome abnormalities in children with Pitt-Hopkins syndrome

Researchers at Signature Genomic Laboratories, which performs diagnostic genetic testing of chromosome abnormalities in individuals with unexplained physical and developmental disabilities, recently showed that microarray analysis can identify small DNA alterations in individuals with Pitt-Hopkins syndrome, a rare and poorly characterized genetic disorder.

19 Nov 2009

Possible new approach to slow the progression of cognitive decline in Down's syndrome

A study by neuroscientist William C. Mobley, MD, PhD, chair of the Department of Neurosciences at the University of California, San Diego School of Medicine, and colleagues at Stanford University Medical School has demonstrated a possible new approach to slowing the inevitable progression of cognitive decline found in Down's syndrome.

19 Nov 2009

Diagnosing patients with syndrome similar to neurofibromatosis type 1 may be difficult

An analysis of patients with a syndrome similar to the genetic disorder, neurofibromatosis type 1, indicates that diagnosis may be difficult because of shared clinical findings, such as certain pigmentary characteristics, according to a study in the November 18 issue of JAMA.

19 Nov 2009

Protein content of women's saliva changes with advancing age, describe scientists

In a step toward using human saliva to tell whether those stiff joints, memory lapses, and other telltale signs of aging are normal or red flags for disease, scientists are describing how the protein content of women's saliva change with advancing age.

19 Nov 2009

Sildenafil drug improves cardiac performance in young adults with congenital heart disease

Heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia.

19 Nov 2009

Results from Phase IIa clinical trial evaluating VT-111 reported by Viron Therapeutics

Viron Therapeutics Inc., a biotechnology company pioneering the development of immune-modulating protein therapeutics derived from pathogens, today reported results from a Phase IIa clinical trial evaluating VT-111 (Serp-1), an anti-inflammatory protein derived from the myxoma virus.

19 Nov 2009

Baby's sleep position can predict misshapen skull condition

A baby's sleep position is the best predictor of a misshapen skull condition known as deformational plagiocephaly - or the development of flat spots on an infant's head - according to findings reported by Arizona State University scientists in the December issue of the journal Pediatrics.

18 Nov 2009

Albireo completes A3309 phase 1b study in patients with chronic idiopathic constipation

Albireo today announced the completion of a phase 1b study showing a favorable tolerability and safety profile of A3309 in patients with chronic idiopathic constipation. In addition, the data revealed appropriate efficacy signals in this patient population. A3309 is a first in class compound developed for the treatment of chronic idiopathic constipation and constipation-predominant Irritable Bowel Syndrome (IBS-C).

18 Nov 2009

Study to test anti-tumor effects of AEOL 10150 initiated

Aeolus Pharmaceuticals, Inc. announced today the initiation of a study to test the anti-tumor effects of AEOL 10150 when combined with radiation and chemotherapy in nude mice bearing human non-small cell lung cancer (NSCLC) xenografts.

18 Nov 2009

Sildenafil improves heart function in youngsters with single ventricle congenital heart disease

Heart function significantly improved in children and young adults with single ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia.

18 Nov 2009

Combination of night work, overtime and shortened sleep can increase risk of stroke and heart disease

A new study published in the current issue of Archives of Environmental & Occupational Health (vol. 64, No. 3) shows that this combination of night work, overtime and shortened sleep can contribute to the development among police officers of the metabolic syndrome, a combination of unhealthful factors that increase the risk of cardiovascular disease (CVD), primarily heart disease and stroke.

18 Nov 2009

Tips on how to prevent household members from getting sick during flu season

someone at home who has H1N1 (swine) flu, it is important for you to prevent other people in the house from getting sick, according to Gary Kalkut, MD, MPH, Senior Vice-President, Chief Medical Officer of Montefiore Medical Center.

18 Nov 2009

Presentations to highlight durability and efficacy of urethral bulking agents

Uroplasty, Inc. (AMEX: UPI), a medical device company developing, manufacturing and marketing innovative proprietary products for the treatment of voiding dysfunctions, today announced that nine abstracts outlining study results submitted by various researchers have been accepted for presentation at the 2010 Annual Meeting of the Society for Urodynamics and Female Urology (SUFU), February 23-27, 2010 in St. Petersburg, FL. Presentations accepted were for both Uroplasty's Urgent® PC Neuromodulation System and Macroplastique® urethral bulking agent products.

17 Nov 2009

Cold weather can trigger Raynaud's disease

Cold weather triggers a painful and sometimes debilitating disorder for millions of Americans who suffer from Raynaud's disease (also known as Raynaud's syndrome or phenomenon). Raynaud's is an autoimmune disorder in which spasms in the blood vessels can interrupt blood flow to the fingers, toes, nose and ears. Exposure to cold triggers the spasms, typically causing the affected area to turn white, then blue, then bright red. Emotional stress can also cause an attack.

17 Nov 2009

PPD, Janssen Pharmaceutica to develop therapeutic compounds for IBS and bacterial infections

PPD, Inc. today announced it has entered an agreement with Janssen Pharmaceutica N.V. to develop and commercialize two Phase II-ready therapeutic compounds, one to treat diarrhea-predominant irritable bowel syndrome (IBS-d) and the other to treat complicated skin and skin structure and respiratory infections.

17 Nov 2009

Pet therapy can have a positive effect on patients’ physical and psychosocial well being

Adults who use pet therapy while recovering from total joint-replacement surgery require 50 percent less pain medication than those who do not. These findings were presented at the 18th Annual Conference of the International Society of Anthrozoology and the First Human Animal Interaction Conference (HAI) in Kansas City, Mo.

17 Nov 2009

Genetic test for familial Dilated Cardiomyopathy launched by PGxHealth

PGxHealth, a division of Clinical Data, Inc., today announced the launch of its genetic test for familial Dilated Cardiomyopathy, an inherited heart disease which is the leading cause of heart transplants and a possible cause of sudden cardiac death.

16 Nov 2009

Postmortem genetic testing to identify genetic mutations after SUD effective in identifying risk

Targeted postmortem testing to identify genetic mutations associated with sudden unexplained death (SUD) is an effective and less expensive way to determine risk to relatives than comprehensive cardiac testing of first degree relatives, according to research presented at the American Heart Association's Scientific Sessions 2009.

16 Nov 2009

Syndrome News and Research

First comprehensive, international baseline evidence about pandemics published

Astellas Pharma and XenoPort submit NDA in Japan for PMDA approval

Microarray analysis can identify chromosome abnormalities in children with Pitt-Hopkins syndrome

Possible new approach to slow the progression of cognitive decline in Down's syndrome

Diagnosing patients with syndrome similar to neurofibromatosis type 1 may be difficult

Protein content of women's saliva changes with advancing age, describe scientists

Sildenafil drug improves cardiac performance in young adults with congenital heart disease

Results from Phase IIa clinical trial evaluating VT-111 reported by Viron Therapeutics

Baby's sleep position can predict misshapen skull condition

Albireo completes A3309 phase 1b study in patients with chronic idiopathic constipation

Study to test anti-tumor effects of AEOL 10150 initiated

Sildenafil improves heart function in youngsters with single ventricle congenital heart disease

Combination of night work, overtime and shortened sleep can increase risk of stroke and heart disease

Tips on how to prevent household members from getting sick during flu season

Presentations to highlight durability and efficacy of urethral bulking agents

Cold weather can trigger Raynaud's disease

PPD, Janssen Pharmaceutica to develop therapeutic compounds for IBS and bacterial infections

Pet therapy can have a positive effect on patients’ physical and psychosocial well being

Genetic test for familial Dilated Cardiomyopathy launched by PGxHealth

Postmortem genetic testing to identify genetic mutations after SUD effective in identifying risk

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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