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Impact of exogenous antibody therapy by convalescent plasma against SARS-CoV-2

Researches have been investigating the possibility of using convalescent plasma to help patients recover from COVID-19.

15 Dec 2021

How fast has the Omicron strain been spreading in South Africa?

Scientists have shown the exponential growth of the Omicron strain found in Gauteng. They reported the doubling time of this strain to be equal to 3.38 days by analyzing its growth from November 8 to December 5, 2021. Based on the mutation accumulation profile, researchers revealed that this strain began to diverge between October 28 and November 5, 2021.

15 Dec 2021

The evolution of SARS-CoV-2 variants during slow and fast epidemics

Researchers discuss an analytical framework to investigate the contribution of the transmissibility advantage SARS-CoV-2 variants.

14 Dec 2021

Nanotrap particles can improve current sequencing workflows of SARS-CoV-2

New research uses an affinity-based magnetic hydrogel particle enrichment technology (Nanotrap particle enrichment technology) that can concentrate viral particles, leading to improved detection of many viral agents including SARS-CoV-2

14 Dec 2021

Assay for the identification of SARS-CoV-2 Spike reactive T and B cells

An interesting new paper presents a new assay for B and T lymphocytes in individuals infected with SARS-CoV-2.

14 Dec 2021

Machine learning method for determining impact of mutations in the SARS-CoV-2 RBD on binding and antibody escape

Deep mutational learning (DML) is a technique developed by researchers from multiple institutions that combines experimental yeast display screening of RBD mutagenesis libraries with deep sequencing and machine learning.

14 Dec 2021

Scientists describe dynamic genomic landscape of tumor heterogeneity in hepatocellular carcinoma

Clinician scientists and scientists from the National Cancer Centre Singapore and A*STAR's Genome Institute of Singapore, in collaboration with Singapore General Hospital, the National University Health System, Duke-NUS Medical School, Nanyang Technological University, and collaborators from China, Malaysia, Thailand and the Philippines, have described a dynamic genomic landscape of tumour heterogeneity in hepatocellular carcinoma (HCC).

13 Dec 2021

Characteristics of vaccine breakthroughs in fully vaccinated individuals in France with delta variant

In a recent observational study, scientists have described the characteristics of VBIs in fully vaccinated individuals in France.

13 Dec 2021

Proactive wins over reactive responses to COVID-19

A new study looks at how the impact of non-pharmaceutical interventions can be quantified and assessed for robustness and resilience.

12 Dec 2021

Autonomous genome annotation of SARS-CoV-2 genes, proteins and domains

In a new research paper, a group of scientists from various institutions offers a semi-supervised custom pipeline for annotating all SARS-CoV-2 genes, proteins, and functional domains.

12 Dec 2021

A pandemic-scale phylogenetic analysis tool

Researchers develop a phylogenetic package that incorporated several pandemic-specific optimization and parallelization techniques.

12 Dec 2021

Machine-learning model could help identify treatments that pose higher risk than other options

Sepsis claims the lives of nearly 270,000 people in the U.S. each year. The unpredictable medical condition can progress rapidly, leading to a swift drop in blood pressure, tissue damage, multiple organ failure, and death.

11 Dec 2021

Study finds mutational changes in Omicron variant likely increase transmissibility

A new study presented evidence for a large number of mutational changes in the Omicron variant which will likely increase its transmissibility and significantly decrease the neutralization capacity of monoclonal antibodies, leading to a decline in vaccine efficacy.

10 Dec 2021

Breathlessness in long COVID patients may be linked to decrease in heart performance

A small study has suggested that COVID-19 patients who continue to be short of breath during physical activity one year after recovering from the infection may have suffered heart damage.

9 Dec 2021

Evolution of the SARS-CoV-2 omicron variant

Study shows that the omicron variant shares a common ancestry with the VOI lambda and has evolved mainly because of non-synonymous mutations.

9 Dec 2021

Novel waveform-based approach to determine the propensity of betacoronaviruses to infect humans

Scientists attempt to understand the evolution of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2.

9 Dec 2021

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

A review article focuses on the efficacy of neutralizing antibodies and vaccines against the SARS-CoV-2 variants.

9 Dec 2021

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

The N-terminal domain has a fold that can bind sugar, and new research led by Jonathan Lees from Oxford Brookes University found the sugar-binding pockets near the N-terminal domain help to increase viral infectivity. Furthermore, the findings show that the SARS-CoV-2 sugar-binding pockets are evolving with added loops observed in the pockets of new variants.

9 Dec 2021

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

Continued replication of severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2) under selective pressure from natural and vaccine-induced immunity has led to the emergence of variants of concern (VOCs) with increased transmissibility or virulence.

8 Dec 2021

Researchers identify a molecular culprit for COVID-19's seasonal nature

Not to pile on, but winter is coming and the COVID-19 pandemic is about to get worse. Not necessarily because of omicron – scientists are still working that one out – but because there’s more evidence than ever that COVID-19 is a seasonal disease.

8 Dec 2021

Evolution News and Research

Impact of exogenous antibody therapy by convalescent plasma against SARS-CoV-2

How fast has the Omicron strain been spreading in South Africa?

The evolution of SARS-CoV-2 variants during slow and fast epidemics

Nanotrap particles can improve current sequencing workflows of SARS-CoV-2

Assay for the identification of SARS-CoV-2 Spike reactive T and B cells

Machine learning method for determining impact of mutations in the SARS-CoV-2 RBD on binding and antibody escape

Scientists describe dynamic genomic landscape of tumor heterogeneity in hepatocellular carcinoma

Characteristics of vaccine breakthroughs in fully vaccinated individuals in France with delta variant

Proactive wins over reactive responses to COVID-19

Autonomous genome annotation of SARS-CoV-2 genes, proteins and domains

A pandemic-scale phylogenetic analysis tool

Machine-learning model could help identify treatments that pose higher risk than other options

Study finds mutational changes in Omicron variant likely increase transmissibility

Breathlessness in long COVID patients may be linked to decrease in heart performance

Evolution of the SARS-CoV-2 omicron variant

Novel waveform-based approach to determine the propensity of betacoronaviruses to infect humans

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

Researchers identify a molecular culprit for COVID-19's seasonal nature

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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