Severe Acute Respiratory News and Research

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How does hybrid immunity shape humoral immune response to SARS-CoV-2?

In a recent study posted to the medRxiv* preprint server, researchers illustrated that hybrid severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity widens effective humoral signatures of SARS-CoV-2 vaccinations.

6 Jul 2022

Research highlights importance of designing effective COVID vaccine allocation strategies

In a recent study posted to the medRxiv* pre-print server, researchers at the University of Melbourne used a modified Susceptible, Exposed, Infectious, and Recovered (SEIR) mathematical model to examine the impact of different vaccine mechanisms and disease characteristics on a population comprised of individuals at high and low risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

6 Jul 2022

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

In a recent study published in the bioRxiv* preprint server, researchers at the Medical University of Innsbruck assessed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3CLpro mutations responsible for Paxlovid resistance. The 3-chymotrypsin-like protease (3CLPro), or main protease (Mpro), is the main protease found in coronaviruses.

6 Jul 2022

Healthy, cancer, and immunosuppressed patients all benefit from COVID boosters

In a recent study posted to the medRxiv* pre-print server, researchers developed a mechanistic mathematical model to predict the course of vaccine-induced immunity in healthy and immunosuppressed patients for the long term, exceeding the time frames for which clinical data is currently available.

5 Jul 2022

Novel inhalable COVID-19 vaccine

A recent study published in the Nature Biomedical Engineering journal illustrated a novel inhalable SARS-CoV-2 vaccine candidate centered on exosomes (Exos) coupled with recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD).

5 Jul 2022

Has the COVID pandemic affected breastfeeding intention?

A new study discusses the impact of the pandemic on breastfeeding practices.

5 Jul 2022

SARS-Cov-2 Omicron variant raises significant concerns about high transmissibility in China

Omicron (B.1.1.529), the fifth variant of concern (VOC) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was firstly identified in November 2021 in South Africa. Omicron contains far more genome mutations than any other VOCs ever found, raising significant concerns about its increased transmissibility and immune evasion.

5 Jul 2022

Next-generation SARS-CoV-2 nucleocapsid-based vaccines may provide optimal protection against infection

In a new study,researchers suggested the inclusion of nucleocapsid protein in vaccines against SARS-CoV-2.

5 Jul 2022

Researchers explore long-term pulmonary sequelae of SARS-CoV-2 infection in the pediatric population

Researchers described the long-term pulmonary sequelae of COVID-19 in the pediatric population.

5 Jul 2022

Deep RNA sequencing with molecular dynamic simulations can detect neutralizing antibodies elicited by COVID-19 patients

In a new study, researchers reported on the non-ACE2 blocking neutralizing antibodies elicited in response to severe coronavirus disease 2019 using deep ribonucleic acid sequencing with >100 million reads per sample and molecular dynamic simulations.

5 Jul 2022

The dynamics of Delta and Omicron establishment and dominance in US states

Researchers analyzed the SARS-CoV-2 Delta and the Omicron VOCs establishment and predominance dynamics in the US.

5 Jul 2022

Effectiveness of two and three doses of BNT162b2 against hospital and ED admissions for BA.1 and BA.2 infection

Researchers compared the effectiveness of two and three-dose regimens of COVID-19 vaccine BNT1262b against Omicron BA.1 and BA.2-related hospital and ED admissions.

5 Jul 2022

Study finds hospitalizations for COVID-19–related croup increased after the onset of the Omicron variant

Researchers assessed whether croup infections among young children in the United States were associated with the emergence of new SARS-CoV-2 variants of concern Omicron.

5 Jul 2022

The evolution of COVID-19 epidemiology in Italy over the first two years of the pandemic

A recent study assessed the SARS-CoV-2 lethality and severity during the two years of the SARS-CoV-2 pandemic in Italy.

5 Jul 2022

The influence of immunosuppressive therapy on the development of adaptive immunity after SARS-CoV-2 vaccination

Researchers evaluated the impact of immunosuppressive therapies on the induction of adaptive immunity after COVID-19 vaccination.

5 Jul 2022

The varying patterns of acute respiratory infection hospitalizations before and during two pandemic years

Investigators analyzed the varying pattern of respiratory viruses resulting in hospitalizations from 2012-2013 to 2021-2022 in Canada.

5 Jul 2022

Vitamin D protects against H1N1 and SARS-CoV-2 infection in mice

Vitamin D supplementation reduces inflammation, after H1N1 and SARS-CoV-2 infections in mice.

5 Jul 2022

Modeling the influence of COVID superspreading events

In a recent study posted to the medRxiv* preprint server, University of Kansas researchers assessed the effect of superspreading events (SSEs) on the United States (US) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak dynamics.

5 Jul 2022

Study looks at pneumococcal carriage among over 60's during COVID pandemic

In a recent article posted to the medRxiv* preprint server, researchers in the United States analyzed the pneumococcal carriage in older adults in the Greater New Haven Area, United States (US), during the implementation of coronavirus disease 2019 (COVID-19) mitigation strategies.

4 Jul 2022

Patient-derived antibody cocktail active across SARS-CoV-2 variants of concern

In a recent study published in the journal Science Immunology, researchers in the United States described a rare anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) three antibody cocktail IMM-BCP-01.

4 Jul 2022

Severe Acute Respiratory News and Research

How does hybrid immunity shape humoral immune response to SARS-CoV-2?

Research highlights importance of designing effective COVID vaccine allocation strategies

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

Healthy, cancer, and immunosuppressed patients all benefit from COVID boosters

Novel inhalable COVID-19 vaccine

Has the COVID pandemic affected breastfeeding intention?

SARS-Cov-2 Omicron variant raises significant concerns about high transmissibility in China

Next-generation SARS-CoV-2 nucleocapsid-based vaccines may provide optimal protection against infection

Researchers explore long-term pulmonary sequelae of SARS-CoV-2 infection in the pediatric population

Deep RNA sequencing with molecular dynamic simulations can detect neutralizing antibodies elicited by COVID-19 patients

The dynamics of Delta and Omicron establishment and dominance in US states

Effectiveness of two and three doses of BNT162b2 against hospital and ED admissions for BA.1 and BA.2 infection

Study finds hospitalizations for COVID-19–related croup increased after the onset of the Omicron variant

The evolution of COVID-19 epidemiology in Italy over the first two years of the pandemic

The influence of immunosuppressive therapy on the development of adaptive immunity after SARS-CoV-2 vaccination

The varying patterns of acute respiratory infection hospitalizations before and during two pandemic years

Vitamin D protects against H1N1 and SARS-CoV-2 infection in mice

Modeling the influence of COVID superspreading events

Study looks at pneumococcal carriage among over 60's during COVID pandemic

Patient-derived antibody cocktail active across SARS-CoV-2 variants of concern

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