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How did SARS-CoV-2 first evolve in humans?

In a perspective article recently published in the journal Science, Hyeryun Choe and Michael Farzan from the Scripps Research Institute, USA, have described the early-stage evolution of SARS-CoV-2 in humans. They have provided a detailed overview of how early mutations in SARS-CoV-2 spike protein facilitate its adaptation in human systems.

7 May 2021

Immunosuppression in COVID-19 promotes emergence of multiple immune escape mutants

An interesting new study describes the emergence of several such variants from a chronically immunosuppressed COVID-19 patient, who remained infected for over 170 days before clearing the virus.

7 May 2021

The ancestor of SARS-CoV-2’s Wuhan strain was circulating in late October 2019

The SARS-CoV-2 was first reported in a case from Wuhan, China, in December 2021, and subsequently became the cause of the COVID-19 pandemic that is ravaging the world today. A new study in the journal Molecular Biology and Evolution tracks its variants all over the world since the onset of the pandemic.

7 May 2021

Bubonic plague had long-term impact on human immune genes, indicates study

Scientists examining the remains of 36 bubonic plague victims from a 16th century mass grave in Germany have found the first evidence that evolutionary adaptive processes, driven by the disease, may have conferred immunity on later generations of people from the region.

7 May 2021

Researchers study the evolutionary origins of tooth and jaw development in living sharks

The origins of a pretty smile have long been sought in the fearsome jaws of living sharks which have been considered living fossils reflecting the ancestral condition for vertebrate tooth development and inference of its evolution.

7 May 2021

About 84% of antibodies in plasma target non-RBD epitopes on SARS-CoV-2 spike protein, finds study

In a new study recently published in the journal Science, a team of researchers in the U.S. found that most of the antibodies circulating in the blood target areas of the viral spike protein outside the receptor-binding domain (RBD), the part of the spike that binds directly to human cell receptors.

6 May 2021

Research shows how the world’s population has created an ideal breeding ground for infectious diseases

The way that many of us live has created the “perfect storm” for the evolution and transmission of infectious diseases like Covid-19 according to a researcher at the University of East Anglia.

6 May 2021

Mammalian olfactory system is also crucial in processing space and surroundings, indicates study

Researchers at the Francis Crick Institute and UCL (University College London) have found that mice can sense extremely fast and subtle changes in the structure of odors and use this to guide their behavior.

6 May 2021

Study could pave way for new therapies for kidney disease

Our kidneys are charged with the extraordinary task of filtering about 53 gallons of fluid a day, a process that depends on podocytes, tiny, highly specialized cells in the cluster of blood vessels in the kidney where waste is filtered that are highly vulnerable to damage.

5 May 2021

Researchers identify new immunotherapy treatment target for acute myeloid leukemia in children

Researchers have identified a gene expressed in children with acute myeloid leukemia (AML) that could serve as a new immunotherapy treatment target, according to a new study published today in Blood Advances, a journal of the American Society of Hematology.

5 May 2021

Study shows how politicization and social mobilization affect the incidence of COVID-19 infection

Measures to contain the Corona pandemic are the subject of politically charged debate and tend to polarize segments of the population.

5 May 2021

Study highlights mechanisms that explain the rise and fall in temporary disability rates

Working conditions, mass layoffs and other economy-related reasons could explain the rises and falls in temporary disability rates.

4 May 2021

Researchers demonstrate real-world effectiveness of Johnson & Johnson COVID-19 vaccine

Researchers in the United States and India have conducted a study demonstrating the real-world effectiveness of a single dose of Johnson & Johnson’s Ad26.COV2.S vaccine at preventing infection with severe acute respiratory syndrome coronavirus 2 – the agent that causes coronavirus disease 2019 (COVID-19).

3 May 2021

New study launched to more accurately diagnose early hepatocellular carcinoma

A first of its kind cohort study on patients at high risk of developing primary liver cancer also known as hepatocellular carcinoma (HCC), has been launched to diagnose HCC more accurately at an earlier stage and to predict an individual's likelihood of developing the cancer.

3 May 2021

Social cognition may exert a central role in the daily lives of MS patients

An international team of multiple sclerosis (MS) researchers showed that longitudinal changes in social cognition are associated with psychological outcomes of daily living, suggesting that social cognition may exert a central role in people with MS.

3 May 2021

Study shows that heart transplantation using donation after cardiac death with NRP is feasible in the U.S.

A new study, presented today at the AATS 101st Annual Meeting, found that heart transplantation using donation after cardiac death (DCD) with normothermic regional perfusion (NRP) is feasible in the United States.

3 May 2021

Low-profile thoracic aortic endograft minimizes complications, increases patient pool

Preliminary results of a clinical trial, presented today at the AATS 101st Annual Meeting, showed that a new, low-profile thoracic aortic endograft is safe and effective in the treatment of descending thoracic aortic aneurysm or penetrating atherosclerotic ulcer (PAU) diseases.

3 May 2021

Study quantifies the true incidence of venous thromboembolism post esophagectomy

A new study presented today at the AATS 101st Annual Meeting, found that the percentage of patients undergoing esophagectomy for cancer who suffer Venous Thromboembolism (VTE) post-operatively is much higher than previously reported, with as many as 24 percent suffering from Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE).

3 May 2021

Researchers identify novel SARS-CoV-2 variant with mutations in membrane protein-encoding gene

A recent study published in the Journal Emerging Microbes and Infections has highlighted the emergence of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant with mutations in the membrane protein-encoding gene. Two potential mutations, M:I82T and M:V70L, have been identified within the transmembrane helices, which are expected to improve viral fitness by modulating glucose uptake during replication.

3 May 2021

Could CRISPR be used as a SARS-CoV-2 antiviral?

The potential of using this gene manipulation technology as a SARS-CoV-2 inhibitor or prophylactic is investigated in a review recently uploaded to the journal Experimental Biology and Medicine (April 25th, 2021) by Arnab Banerjee and colleagues.

2 May 2021

Evolution News and Research

How did SARS-CoV-2 first evolve in humans?

Immunosuppression in COVID-19 promotes emergence of multiple immune escape mutants

The ancestor of SARS-CoV-2’s Wuhan strain was circulating in late October 2019

Bubonic plague had long-term impact on human immune genes, indicates study

Researchers study the evolutionary origins of tooth and jaw development in living sharks

About 84% of antibodies in plasma target non-RBD epitopes on SARS-CoV-2 spike protein, finds study

Research shows how the world’s population has created an ideal breeding ground for infectious diseases

Mammalian olfactory system is also crucial in processing space and surroundings, indicates study

Study could pave way for new therapies for kidney disease

Researchers identify new immunotherapy treatment target for acute myeloid leukemia in children

Study shows how politicization and social mobilization affect the incidence of COVID-19 infection

Study highlights mechanisms that explain the rise and fall in temporary disability rates

Researchers demonstrate real-world effectiveness of Johnson & Johnson COVID-19 vaccine

New study launched to more accurately diagnose early hepatocellular carcinoma

Social cognition may exert a central role in the daily lives of MS patients

Study shows that heart transplantation using donation after cardiac death with NRP is feasible in the U.S.

Low-profile thoracic aortic endograft minimizes complications, increases patient pool

Study quantifies the true incidence of venous thromboembolism post esophagectomy

Researchers identify novel SARS-CoV-2 variant with mutations in membrane protein-encoding gene

Could CRISPR be used as a SARS-CoV-2 antiviral?

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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