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Obesity and diabetes each double the risk of heart failure - patients with both conditions ‘very difficult’ to treat

The twin epidemics of obesity and type 2 diabetes will continue to fuel an explosion in heart failure, already the world's most prevalent chronic cardiovascular disease, according to John McMurray, professor of cardiology at the Western Infirmary, Glasgow, and President of the Heart Failure Association. He reported that around one-third of patients with heart failure have evidence of diabetes, and for them the outlook is very serious. For doctors, he added, effective treatment is "very difficult".

31 May 2009

DNA compounds show promise for Lupus

A research team led by a University of Iowa investigator has generated DNA-like compounds that effectively inhibit the cells responsible for systemic lupus erythematosus -- the most common and serious form of lupus. There currently is no cure for this chronic autoimmune condition that damages the skin, joints and internal organs and affects an estimated one million Americans.

27 May 2009

Pledges to reduce health care costs, spending growth could violate antitrust laws, lawyers say

U.S. antitrust laws could affect health care industry groups' efforts to work together to rein in health care costs, the New York Times reports (Pear, New York Times, 5/27).

27 May 2009

Common migraine pain condition allodynia also prevalent in cluster headache

A pain condition common in people with migraines also has a high prevalence in patients with cluster headache, according to a study conducted by researchers at the Jefferson Headache Center at Jefferson Hospital for Neuroscience.

27 May 2009

FDA grants full approval for Sprycel (dasatinib) for chronic myeloid leukemia

Bristol-Myers Squibb Company has announced that the U.S. Food and Drug Administration (FDA) has granted full approval for Sprycel (dasatinib) for the treatment of adults in all phases of chronic myeloid leukemia (CML) (chronic, accelerated, or myeloid or lymphoid blast phase) with resistance or intolerance to prior therapy including Gleevec (imatinib mesylate).

27 May 2009

1 in 7 Australians over 25 have chronic kidney disease

The latest report from the Australian Institute of Health and Welfare (AIHW) says between 2006 and 2007 more than a million hospital admissions in Australia were due to chronic kidney disease which was also a contributing factor in one in 10 deaths in 2006.

26 May 2009

Activated stem cells in damaged lungs could be first step toward cancer

Stem cells that respond after a severe injury in the lungs of mice may be a source of rapidly dividing cells that lead to lung cancer, according to a team of American and British researchers.

26 May 2009

Cancer drug capecitabine causes patient to lose fingerprints and be detained by U.S. immigration

Immigration officials held a cancer patient for four hours before they allowed him to enter the USA because one of his cancer drugs caused his fingerprints to disappear. His oncologist is now advising all cancer patients who are being treated with the commonly used drug, capecitabine, to carry a doctor's letter with them if they want to travel to the USA.

26 May 2009

The future of migraine: beyond just another pill

Patients living with migraine have strong reason for new optimism concerning a positive future. Two review articles and an accompanying editorial, "The Future of Migraine: Beyond Just Another Pill," in the current issue of Mayo Clinic Proceedings, are the basis for an ironic premise.

26 May 2009

Active ingredient in green tea shows promise in leukemia trials

Mayo Clinic researchers are reporting positive results in early leukemia clinical trials using the chemical epigallocatechin gallate (EGCG), an active ingredient in green tea.

26 May 2009

Novel chemotherapy and biological agents brings dramatic increase in metastatic colon cancer survival

Novel chemotherapy and biological agents for metastatic colorectal cancer, combined with surgical advances in liver resection, have resulted in a dramatic increase in survival for patients with advanced disease, according to researchers at The University of Texas M. D. Anderson Cancer Center.

26 May 2009

Discovery of biological markers that may indicate poor breast cancer prognosis

A team of researchers has found an association between breast cancer survival and two proteins that, when present in the blood in high levels, are indicators of inflammation.

26 May 2009

Hospital refuses admission to young adults with thalassemia and sickle cell disease

Young adults with thalassemia and sickle cell diease have been trying for up to 10 years to gain admission to the only adult hospital program in central and southwestern Toronto specialized to treat their blood disorders. Since 1999, the Toronto General Hospital (TGH) has restricted the inherited blood disorders program to 99 patients requiring blood transfusions. As a result, about 150 young adults with complex disorders receive blood transfusions at the Hospital for Sick Children but no adult services.

25 May 2009

Discovery of genetic link between periodontitis and heart attack

The relationship between the dental disease periodontitis and coronary heart disease (CHD) has been known for several years. Although a genetic link seemed likely, until now its existence was uncertain. Now, for the first time, scientists have discovered a genetic relationship between the two conditions, a researcher told the annual conference of the European Society of Human Genetics today (Monday 25 May).

25 May 2009

Development of innovative nanotechnology drug delivery system for the treatment of pain

Z-Cube Srl, the corporate venture arm of Zambon Company SpA, and Yissum Research Development Company Ltd., the technology transfer company of the Hebrew University of Jerusalem, announced today that they have entered into a license agreement for Z-Cube to develop and commercialize an innovative nanotechnology drug delivery system for the treatment of pain.

25 May 2009

Researchers unlock mystery of potentially fatal reaction to smallpox vaccine

Researchers from the La Jolla Institute for Allergy & Immunology have pinpointed the cellular defect that increases the likelihood, among eczema sufferers, of developing eczema vaccinatum, a severe and potentially fatal reaction to the smallpox vaccine.

25 May 2009

Call for vaccination against HPV 16 in young men and women to prevent head and neck cancers

Researchers at Roswell Park Cancer Institute (RPCI) in Buffalo, New York, are strongly advocating a national discussion about the need to vaccinate both young men and women against HPV 16 to prevent head & neck cancers.

22 May 2009

Tuberculosis can evade immune response

Current research suggests that Mycobacterium tuberculosis can evade the immune response. The related report by Rahman et al, "Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory T cells in the granulomatous lesions," appears in the June 2009 issue of The American Journal of Pathology.

22 May 2009

Novel method stimulates growth of new neurons in adult brain

University at Buffalo researchers have identified a new mechanism that plays a central role in adult brain stem cell development and prompts brain stem cells to differentiate into neurons.

21 May 2009

Study offers new insights into morphine-induced tolerance and increased pain sensitivity

A study published in the June issue of Anesthesiology has shown that a drug metabolite of the opioid morphine may be a key factor in the paradoxical increased sensitivity to pain caused by chronic morphine use. For the first time, this metabolite (called morphine-6 glucuronide, or M6G) was shown to act independently of the pain receptors typically targeted during morphine administration.

21 May 2009

Chronic News and Research

Obesity and diabetes each double the risk of heart failure - patients with both conditions ‘very difficult’ to treat

DNA compounds show promise for Lupus

Pledges to reduce health care costs, spending growth could violate antitrust laws, lawyers say

Common migraine pain condition allodynia also prevalent in cluster headache

FDA grants full approval for Sprycel (dasatinib) for chronic myeloid leukemia

1 in 7 Australians over 25 have chronic kidney disease

Activated stem cells in damaged lungs could be first step toward cancer

Cancer drug capecitabine causes patient to lose fingerprints and be detained by U.S. immigration

The future of migraine: beyond just another pill

Active ingredient in green tea shows promise in leukemia trials

Novel chemotherapy and biological agents brings dramatic increase in metastatic colon cancer survival

Discovery of biological markers that may indicate poor breast cancer prognosis

Hospital refuses admission to young adults with thalassemia and sickle cell disease

Discovery of genetic link between periodontitis and heart attack

Development of innovative nanotechnology drug delivery system for the treatment of pain

Researchers unlock mystery of potentially fatal reaction to smallpox vaccine

Call for vaccination against HPV 16 in young men and women to prevent head and neck cancers

Tuberculosis can evade immune response

Novel method stimulates growth of new neurons in adult brain

Study offers new insights into morphine-induced tolerance and increased pain sensitivity

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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