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Targeting cyclin-dependent kinases offers new pathways for cancer therapy

Cancer is the second leading cause of death in Germany. In the search for new therapeutic approaches that target the uncontrolled growth of tumor cells, a class of enzymes known as cyclin-dependent kinases (CDKs) has come into focus.

24 Aug 2026

Disrupted brain-immune signaling may help drive neurodegeneration

A Cell perspective argues that neurodegeneration can emerge from disrupted communication between neural and immune networks, with peripheral immunity, microglia, and gene-regulatory programs all shaping disease processes. The authors propose that restoring immune homeostasis and recalibrating neuroimmune circuits could create new therapeutic and diagnostic opportunities, while emphasizing that many mechanisms remain unresolved in humans.

24 Aug 2026

Review outlines how SIRT3 protein regulates global metabolic disorders

A comprehensive review published in Engineering systematically outlines the regulatory capacity of silent information regulator 3 (SIRT3), a mitochondrial deacetylase termed the "head goose molecule", and its negentropic mechanism for intervening global metabolic disorders including type 2 diabetes, obesity, and steatotic liver disease.

21 Aug 2026

Cryo-EM provides real-time glimpse of cellular machinery reading DNA inside living organisms

All living things have a fleet of tiny copy machines that turn instructions from DNA into RNA, the molecules responsible for helping build proteins that keep organisms alive.

20 Aug 2026

Glioma microenvironment emerges as key target for future therapies

The prognosis for glioma patients remains extremely poor despite aggressive multimodal standard therapy: maximal safe resection, radiotherapy, and temozolomide chemotherapy, with median survival rarely exceeding 15 to 18 months.

20 Aug 2026

Study provides new insights into how IL-26 reshapes the tumor immune landscape

While cancer cells acquire malignant traits through epigenetic remodeling, it remains unclear how immune-derived inflammatory factors regulate the epigenetics of colorectal cancer cells.

18 Aug 2026

First high-resolution cell-by-cell map tracks tomato root and fungal partnership

Scientists at VIB and Ghent University have produced the first high-resolution, cell-by-cell map of how tomato roots respond to colonization by arbuscular mycorrhizal fungi.

18 Aug 2026

Opening the black box of biological aging clocks

What do "epigenetic clocks" actually measure? These lab tests have become popular tools for studying biological aging, or how the body's cellular function changes at a faster or slower rate than expected.

14 Aug 2026

Salk scientists use DNA origami to track molecular movements

Scientists often describe life as a series of chemical reactions. Pallav Kosuri, PhD, describes life as movement. Chemical reactions are how you drive the movement of atoms, proteins, cells, and bodies-without movement, there is no life.

14 Aug 2026

New method enables more precise labeling of protein-protein interactions in cancer-specific cells

Using a photochemically driven labeling technique, a Cornell University-led research group has devised a strategy for capturing cancer-specific protein-to-protein interactions, which could one day spawn targeted therapies for prostate, small-cell lung, pancreatic and other deadly forms of the disease.

14 Aug 2026

Astrocytes found to directly regulate memory consolidation during sleep

Research has shown that a good night's sleep has many benefits, including memory consolidation. How sleep enables the brain to strengthen memories is still not completely understood, but a new study published in Neuron reveals how astrocytes, brain cells known for supporting neurons and their functions, can directly regulate brain circuits involved in memory consolidation.

13 Aug 2026

Mitochondrial rewiring may explain why orthoflaviviruses harm humans but persist in mosquitoes

Orthoflaviviruses reshape mitochondrial structure, metabolism, redox signaling, and quality control differently across human and mosquito models, helping explain their contrasting infection outcomes. The review highlights mitochondrial pathways that may support acute cellular damage in vertebrates but persistent, non-lethal infection in mosquitoes, pointing to potential antiviral targets.

12 Aug 2026

Exhausted T cells balance graft tolerance and infection risk

A comprehensive new review examines the complex role of T cell exhaustion in organ transplantation, highlighting how this dysfunctional immune state can both promote graft tolerance and create vulnerabilities to infection and malignancy.

7 Aug 2026

Researchers discover smart molecular glue that activates inside oxidative cancer cells

Investigators at Dana-Farber Cancer Institute have developed a platform for systematically discovering molecular glues that could become protein degradation drug candidates.

7 Aug 2026

Autophagy modulation emerges as a strategy against cisplatin-resistant gastric cancer

Drug resistance remains one of the greatest obstacles to successful treatment of gastric cancer, limiting the long-term effectiveness of the widely used chemotherapy drug cisplatin.

6 Aug 2026

Tuft cell-like cancers exhibit unique biological characteristics across multiple organs

A growing body of evidence suggests that a rare epithelial cell type known as the tuft cell may play a far more significant role in cancer than previously recognized.

6 Aug 2026

LMU researchers reveal how different organs customize their internal clocks

LMU researchers have elucidated how different organs adapt the same clock machinery to regulate their individual needs over the course of a day.

6 Aug 2026

Study identifies a novel direct drug target for head and neck squamous cell carcinoma

Chemotherapy remains a cornerstone of treatment for head and neck cancers, the seventh-most common cancer type worldwide.

6 Aug 2026

New review highlights FOXA2's role in glucose regulation pathways

A newly published review highlights the pivotal role of FOXA2, a key transcription factor, in coordinating pancreatic development, maintaining islet cell identity, and regulating glucose homeostasis.

6 Aug 2026

Restricting select amino acids may mimic protein restriction’s healthy aging benefits

A review finds that restricting protein, particularly methionine, isoleucine, and valine, may improve metabolism and influence key aging pathways, largely in experimental models. Short human studies suggest metabolic benefits, but effects on lifespan remain unknown and restriction may harm people with unmet or increased protein needs.

3 Aug 2026

Transcription News and Research

Targeting cyclin-dependent kinases offers new pathways for cancer therapy

Disrupted brain-immune signaling may help drive neurodegeneration

Review outlines how SIRT3 protein regulates global metabolic disorders

Cryo-EM provides real-time glimpse of cellular machinery reading DNA inside living organisms

Glioma microenvironment emerges as key target for future therapies

Study provides new insights into how IL-26 reshapes the tumor immune landscape

First high-resolution cell-by-cell map tracks tomato root and fungal partnership

Opening the black box of biological aging clocks

Salk scientists use DNA origami to track molecular movements

New method enables more precise labeling of protein-protein interactions in cancer-specific cells

Astrocytes found to directly regulate memory consolidation during sleep

Mitochondrial rewiring may explain why orthoflaviviruses harm humans but persist in mosquitoes

Exhausted T cells balance graft tolerance and infection risk

Researchers discover smart molecular glue that activates inside oxidative cancer cells

Autophagy modulation emerges as a strategy against cisplatin-resistant gastric cancer

Tuft cell-like cancers exhibit unique biological characteristics across multiple organs

LMU researchers reveal how different organs customize their internal clocks

Study identifies a novel direct drug target for head and neck squamous cell carcinoma

New review highlights FOXA2's role in glucose regulation pathways

Restricting select amino acids may mimic protein restriction’s healthy aging benefits

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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