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Unconventional wiring of the brain circuits that govern sleep and waking might explain the prevalence of insomnia

Unconventional wiring of the brain circuits that govern sleep and waking might explain the prevalence of insomnia and the condition's association with obesity, according to new work published in the April issue of Cell Metabolism. Characterized by a chronic inability to fall asleep or remain sleeping, insomnia is estimated to affect one in every eight Americans.

12 Apr 2005

Study predicted cardiovascular risk of Cox-2 inhibitors

Amid the recent controversy and confusion over serious side effects from pain medications, a new UCLA and Veterans Affairs Greater Los Angeles Healthcare System study demonstrates that for arthritis sufferers at high risk for gastrointestinal problems who traditionally may have used a drug like Vioxx, the most cost-effective and safest treatment is actually a common painkiller combined with an acid-reducing drug.

11 Apr 2005

Bextra withdrawn from market, strong warnings on popular painkillers

The U.S. Food and Drug Administration (FDA) has issued warnings that most popular painkillers can hurt the heart, stomach and skin, and they have told pharmaceutical giant Pfizer to withdraw Bextra a top selling painkiller.

10 Apr 2005

Hemodialysis causes antioxidant loss leading to long-term complications

An article published in Hemodialysis International discusses the role of oxidative stress (OS) in dialysis patients, an imbalance which can result in long-term health problems. Potential therapeutic options to restore balance in patients are also reviewed.

10 Apr 2005

Novel human kidney protein called renalase that regulates both heart contraction and blood pressure

Researchers at Yale School of Medicine and the VA Connecticut Healthcare System in West Haven identified a novel human kidney protein called renalase that regulates both heart contraction and blood pressure; it is a strong candidate for easily administered treatment of advanced kidney and cardiovascular disease.

10 Apr 2005

Cyclosporine inhalation solution (CyIS) significantly improves long-term survival in lung-transplant patients

Data presented for the first time at the 25th Annual Meeting and Scientific Session of the International Society for Heart and Lung Transplantation (ISHLT) show that cyclosporine inhalation solution (CyIS) significantly improves long-term survival in lung-transplant patients compared to placebo.

10 Apr 2005

Three out of every four adults over age 50 use some kind of alternative medicine

This study found that 71 percent of older adults used some form of alternative medicine in 2000. A study done in 2002, found a lower rate -- about 62 percent – among all adults.

10 Apr 2005

Teens feel most stress before HIV-infected parent dies

A UCLA AIDS Institute study has discovered that teens of HIV-infected parents are at the highest risk for depression and self-destructive behavior before their parent's death, not after. Published in the April issue of the Journal of Consulting and Clinical Psychology, the findings emphasize the importance of providing support services to HIV-affected families promptly after a parent's diagnosis and through the subsequent illness — not only after the parent's death.

7 Apr 2005

Pfizer withdraws Bextra from market

Despite an expert panel stating last month that the three COX-2 drugs Vioxx, Bextra and Celebrex were safe enough to be marketed, the U.S. Food and Drug Administration (FDA) has this week told drug manufacturer Pfizer to remove the drug Bextra from the market and a statement by Pfizer confirms that the European Union regulators have done the same.

7 Apr 2005

Role of oxidative stress (OS) in dialysis patients

7 Apr 2005

Fibril shape is the basis of prion strains and cross-species prion infection

New research on prions, the infectious proteins behind "mad cow" disease and Creutzfeld-Jakob disease in humans, suggests that the ability of prions in one species to infect other species depends on the shape of the toxic threadlike fibers produced by the prion. Two studies on the topic appear in the 8 April issue of the journal Cell.

7 Apr 2005

Epstein-Barr virus may increase risk of lupus

Almost everyone has been infected with Epstein-Barr virus (EBV), a member of the herpes family and one of the most common human viruses.

7 Apr 2005

Competition in health care may not result in better quality

For several decades, competition within the health care industry has been touted as the way to curb rising prices by reducing inefficient practices and improving quality and safety. But a study of 341 HMOs suggests that more competition may not automatically solve price and quality-of-care problems as hoped for by legislators, regulators and employers.

7 Apr 2005

Pneumonia jab now available for over 65s in UK

People over 65 in the UK are to be offered a routine jab to help protect against diseases, including pneumonia, meningitis and septicaemia. Two in 1,000 over-65s are admitted to hospital with pneumococcal pneumonia each year and the infection can cause serious diseases.

5 Apr 2005

Sildenafil prevents anti-cancer drug induced heart damage

Virginia Commonwealth University researchers have found that the popular impotence drug Viagra prevents damage to the heart from a potent chemotherapeutic agent frequently used in the treatment of breast cancer, leukemia and sarcomas.

5 Apr 2005

Weight loss surgery is the most effective treatment available for obesity say experts

A panel of experts charged with reviewing all the available evidence on morbid obesity and weight loss surgery today concluded weight loss surgery is the most effective treatment available and can result in the improvement or complete resolution of diseases associated with obesity, according to a consensus statement published in the April edition of the Journal of the American College of Surgeons (JACS).

5 Apr 2005

Certain combinations of genes increase the risk of developing cervical cancer

Certain combinations of genes that encode receptors on innate immune cells increase the risk of developing cervical cancer, according to a study by Mary Carrington and colleagues in the April 4 issue of The Journal of Experimental Medicine.

4 Apr 2005

Natural killer cells could lead to new Hepatitis treatments

Researchers have discovered that natural killer T (NKT) cells, the immune system's sentinels, patrol the labyrinthine blood vessels of the liver for invaders or signs of tissue damage and demonstrate a dogged behavior not seen before in other T cells.

4 Apr 2005

Effect of individualized diets on chronic disease risk

Today at the 2005 Experimental Biology Conference, the Dairy Council of California sponsored a thought-provoking symposium titled "Individualized nutrition as a tool to prevent and treat chronic disease."

4 Apr 2005

Chronic inflammation caused by too little stomach acid leads to gastric cancer

When it comes to gastric cancer, too little stomach acid can be just as dangerous as too much, according to scientists at the University of Michigan Medical School. Both extremes create inflammatory changes in the stomach lining and a condition called chronic atrophic gastritis, which over time often leads to cancer.

4 Apr 2005