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PathCentral releases APLIS platform to serve the needs of community pathologist

PathCentral, a technology-enabled company dedicated to the success of the pathology community, today introduced AP Anywhere, its bundled Anatomic Pathology Laboratory Information System technology offering.

20 May 2013

Study reveals how and why developmental genes often take inputs from 2 independent sources

Albert Erives, associate professor in the University of Iowa Department of Biology, and his graduate student, Justin Crocker, currently a postdoctoral researcher at the Howard Hughes Medical Institute Janelia Farm Research Campus, have conducted a study that reveals important and useful insights into how and why developmental genes often take inputs from two independent "morphogen concentration gradients."

16 May 2013

New study reveals another duet played by Notch and BMP signals

A small ensemble of musicians can produce an infinite number of melodies, harmonies and rhythms. So too, do a handful of workhorse signaling pathways that interact to construct multiple structures that comprise the vertebrate body.

15 May 2013

Better understanding of cells' development has implications in study of inflammatory diseases

Labs around the world, and a core group at Penn, have been studying recently described populations of immune cells called innate lymphoid cells. Some researchers liken them to foot soldiers that protect boundary tissues such as the skin, the lining of the lung, and the lining of the gut from microbial onslaught. They also have shown they play a role in inflammatory disease, when the body's immune system is too active.

15 May 2013

Study: Rb plays critical role in maintaining starvation-induced transcriptome

A particular tumor suppressor gene that fights cancer cells does more than clamp down on unabated cell division -- the hallmark of the disease -- it also can help make cells more fit by allowing them to fend off stress, says a University of Colorado Boulder study.

13 May 2013

Drug resistant brain tumors: an interview with Prof. Mischel, Ludwig Institute for Cancer Research and Prof. Bensinger, University of California

In cancer, mutations in proteins that control cell growth are common, leading to unrestrained cellular proliferation and tumor formation.

9 May 2013

Hospital Safety Score: Hospitals make only incremental progress in patient safety

When it comes to patient safety, all hospitals and U.S. states aren't created equal, according to the newly updated Hospital Safety Score. The Spring 2013 update to the Hospital Safety Score that assigns "A," "B," "C," "D" or "F" grades to more than 2,500 general hospitals in the United States showed hospitals have made only incremental progress in addressing errors, accidents, injuries and infections that kill or hurt their patients.

8 May 2013

Testing Stat5 gene amplification in prostate cancer patients could provide powerful therapy: Study

An international group of investigators, led by researchers at Thomas Jefferson University's Kimmel Cancer Center, have solved the mystery of why a substantial percentage of castrate-resistant metastatic prostate cancer cells contain abnormally high levels of the pro-growth protein Stat5.

8 May 2013

Study offers new hope to patients suffering from laminopathies

Laminopathies are hereditary diseases that affect mainly the muscle tissue. These diseases include for example Emery-Dreifuss Muscular dystrophy, dilated cardiomyopathy, limb-girdle muscular dystrophy and Hutchison-Gilford progeria syndrome.

7 May 2013

Expert to explain how drugs induce damage to DNA in public lecture on May 16

Anticancer drugs save lives and/or improve the quality of life for many cancer patients. Many anti-cancer drugs work by killing tumor cells after inducing damage to DNA.

4 May 2013

Gene study may uncover regulatory network that influences development of cardiovascular disease

University of North Carolina researchers have discovered that disrupting a gene that acts as a regulatory switch to turn on other genes can keep blood vessels from forming and developing properly.

30 Apr 2013

Study: Blocking certain enzymes in cell may prevent cancer cell division and growth

Blocking certain enzymes in the cell may prevent cancer cell division and growth, according to new findings from researchers at the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai.

26 Apr 2013

New hope for patients with chronic HBV infection

Exciting new data presented today at the International Liver Congress- 2013 include rults from early in vitro and in vivo studies targeting covalently closed circular DNA (cccDNA), which may form the basis of a cure for chronic hepatitis B virus (HBV) infection.

25 Apr 2013

Research supports polygenic phenotype in schizophrenia

Cumulative genetic risk for schizophrenia has been linked to impaired prefrontal brain activity, in findings that support an additive genetic risk model for a polygenic phenotype.

25 Apr 2013

Individuals with MEN1 are at increased risk of developing neuroendocrine tumors

A mutation in a protein called menin causes a hereditary cancer syndrome called MEN1 (multiple endocrine neoplasia type 1).

25 Apr 2013

Researchers decode toggle switch that can stimulate fat burning

For a long time, scientists have dreamt of converting undesirable white fat cells into brown fat cells and thus simply have excess pounds melt away. Researchers at the University of Bonn have now gotten a step closer to this goal: They decoded a "toggle switch" in mice which can significantly stimulate fat burning.

24 Apr 2013

Exposure to chemical pesticide has impacts that span multiple generations, say researchers

North Carolina State University researchers studying aquatic organisms called Daphnia have found that exposure to a chemical pesticide has impacts that span multiple generations - causing the so-called "water fleas" to produce more male offspring, and causing reproductive problems in female offspring.

23 Apr 2013

High dietary salt combined with ulcer infection greatly increases risk of gastric cancer

Numerous epidemiologic studies have shown that a diet high in salt is associated with an increased risk of gastric cancer.

19 Apr 2013

Three missense variants of BRCA1 gene linked to breast or ovarian cancer risk, study shows

Researchers of the hereditary cancer research group at the Bellvitge Biomedical Research Institute and the Catalan Institute of Oncology conducted a functional and structural study of seven missense variants of the BRCA1 gene concluding that three of these variants are pathogenic, linked to the risk of suffering breast or ovarian cancer.

19 Apr 2013

Investigators report that cell-permeable NLS peptide shows promise in controlling atherosclerotic disease

Atherosclerosis - sometimes called "hardening of the arteries" - is a leading cause of death and morbidity in Western countries. A cell-permeable peptide containing the NF-ĸB nuclear localization sequence (NLS) shows promise as a potential agent in controlling the development of atherosclerotic disease.

18 Apr 2013

Transcription News and Research

PathCentral releases APLIS platform to serve the needs of community pathologist

Study reveals how and why developmental genes often take inputs from 2 independent sources

New study reveals another duet played by Notch and BMP signals

Better understanding of cells' development has implications in study of inflammatory diseases

Study: Rb plays critical role in maintaining starvation-induced transcriptome

Drug resistant brain tumors: an interview with Prof. Mischel, Ludwig Institute for Cancer Research and Prof. Bensinger, University of California

Hospital Safety Score: Hospitals make only incremental progress in patient safety

Testing Stat5 gene amplification in prostate cancer patients could provide powerful therapy: Study

Study offers new hope to patients suffering from laminopathies

Expert to explain how drugs induce damage to DNA in public lecture on May 16

Gene study may uncover regulatory network that influences development of cardiovascular disease

Study: Blocking certain enzymes in cell may prevent cancer cell division and growth

New hope for patients with chronic HBV infection

Research supports polygenic phenotype in schizophrenia

Individuals with MEN1 are at increased risk of developing neuroendocrine tumors

Researchers decode toggle switch that can stimulate fat burning

Exposure to chemical pesticide has impacts that span multiple generations, say researchers

High dietary salt combined with ulcer infection greatly increases risk of gastric cancer

Three missense variants of BRCA1 gene linked to breast or ovarian cancer risk, study shows

Investigators report that cell-permeable NLS peptide shows promise in controlling atherosclerotic disease

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