Severe Acute Respiratory News and Research

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SARS-CoV-2 viral mutations shown to have a limited effect on T cell immunity

New research suggests that viral mutations have a minimal effect on T cell immunity, which could explain the protection provided by vaccination against severe COVID-19, despite the significant loss of neutralizing antibodies.

10 Jan 2022

Effectiveness of prior infection in preventing reinfection with Omicron and other SARS-CoV-2 variants in Qatar

Researchers estimate the effectiveness of prior infection in preventing reinfection (PEs) with Omicron and other SARS-CoV-2 variants for the resident population of Qatar.

10 Jan 2022

Efficacy of surgical masks and N95 respirators in lowering SARS-CoV-2 transmission

In a new study, researchers determined the adherence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant to masks and respirators and the role of buccal protection in controlling SARS-CoV-2 transmission.

10 Jan 2022

Neutralization of SARS-CoV-2 variants by three-dose mRNA vaccinated kidney transplant recipient sera

In a new study, researchers determined three-dose messenger ribonucleic acid (mRNA) vaccinated kidney transplant recipients’ (KTRs) neutralizing responses against SARS-COV-2 variants, breakthrough coronavirus disease 2019 infection rate, and transplant rejection rate.

10 Jan 2022

Incidence rates of psychiatric diagnoses and drugs in Israeli adolescents before and during the COVID-19 pandemic

Researchers investigated the incidence of psychiatric diagnoses of Israeli adolescents before and during the COVID-19 pandemic.

10 Jan 2022

Mathematical modeling the vaccination of children against SARS-CoV-2

Researchers evaluated the safety of mRNA vaccination against SARS-CoV-2 in children using mathematical modeling.

10 Jan 2022

Durability of vaccine protection against COVID-19 breakthrough infections and hospitalizations

In a new study, researchers investigated the duration of protection provided by the coronavirus disease 2019 vaccines available in the United States against breakthrough infections, hospitalizations, and intensive care unit admissions.

10 Jan 2022

Humoral and cellular response to primary and booster COVID-19 vaccination in immunosuppressed patients

Researchers posted the results of a retrospective observational cohort study in which they determined the humoral and cellular responses in ISP to primary and booster doses of COVID-19 vaccines.

10 Jan 2022

SARS-CoV-2 Omicron variant's infectivity, vaccine breakthrough, and antibody resistance

A recent study uses an artificial intelligence model to investigate Omicron's mutations and its infectivity, vaccine escape capability, and susceptibility to monoclonal antibodies.

10 Jan 2022

SARS-CoV-2 omicron variant predicted to cause fewer deaths in Florida

Scientists have predicted a lower number of infections and deaths caused by the omicron variant of severe acute respiratory syndrome coronavirus 2 in Florida

10 Jan 2022

SARS-CoV-2 shown to spread through cell-to-cell transmission

A new study investigated SARS-CoV-2 cell-to-cell transmission in the context of cell-free infection and compared it to SARS-CoV.

10 Jan 2022

Declining effectiveness of the BNT162b2 vaccine in adolescents infected with COVID-19

Researchers have conducted a retrospective matched case-control study to determine the protection period conferred by the BNT162b2 vaccine on adolescents aged 12 to 16.

10 Jan 2022

SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

In a new study, researchers used a cell-cell fusion assay to extract potentially cleaved spike protein products from syncytia in order to explore the functional and biochemical characteristics of spike (S) protein when it engages its receptor ACE2 in living cells.

10 Jan 2022

Association of vaccination status with Long COVID symptoms

Scientists examined whether vaccination was associated with reporting long-term symptoms post-SARS-CoV-2 infection.

10 Jan 2022

Researchers plan to review the effect of SARS-CoV-2 on male reproductive health

In a protocol published in BMJ Open, researchers from the Chengdu University of Traditional Chinese Medicine plan to review current studies in this area.

10 Jan 2022

Strategy for capturing SARS-CoV-2 through functionalized cellulose materials

Researchers from Northeastern University have developed a new, more cost-effective method for immobilizing SARS-CoV-2.

10 Jan 2022

SARS-CoV-2 Delta sublineage AY.4.2 shows no increase in cell entry or antibody evasion

Researchers from Germany, in their recent study published in the journal Cellular & Molecular Immunology, have evaluated the mutations in the S protein of one such SARS-CoV-2 strain, a Delta sublineage AY.4.2, which is currently expanding in the UK, and have found that it neither contains any potential for increased cell entry nor antibody escape.

10 Jan 2022

New lab-on-a-chip platform for detecting SARS-CoV-2 in resource-limited settings

A recent study shows how a novel and integrated lab-on-a-chip platform can represent a rapid, affordable, and exact molecular diagnostic tool for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The paper is currently available for free on the medRxiv* preprint server while it undergoes peer review.

9 Jan 2022

History of SARS-CoV-2 infection affects longitudinal responses to BNT162b2 vaccine

In a recently published article in the journal Cell Reports, scientists have demonstrated that individuals with or without a history of coronavirus disease 2019 (COVID-19) exhibit differential humoral and cellular immune responses 14 days after receiving mRNA-based COVID-19 vaccine developed by Pfizer/BioNTech. However, at a later time point, the responses become comparable between the two groups.

9 Jan 2022

Influenza vaccination does not affect risk of SARS-CoV-2 infection or COVID-19

A new study published in The Journal of Infectious Diseases examined if influenza vaccination altered the risk of SARS-CoV-2 infection and clinical outcomes of COVID-19. The study included health care workers (HCWs) from Denmark who were offered influenza vaccination.

9 Jan 2022

Severe Acute Respiratory News and Research

SARS-CoV-2 viral mutations shown to have a limited effect on T cell immunity

Effectiveness of prior infection in preventing reinfection with Omicron and other SARS-CoV-2 variants in Qatar

Efficacy of surgical masks and N95 respirators in lowering SARS-CoV-2 transmission

Neutralization of SARS-CoV-2 variants by three-dose mRNA vaccinated kidney transplant recipient sera

Incidence rates of psychiatric diagnoses and drugs in Israeli adolescents before and during the COVID-19 pandemic

Mathematical modeling the vaccination of children against SARS-CoV-2

Durability of vaccine protection against COVID-19 breakthrough infections and hospitalizations

Humoral and cellular response to primary and booster COVID-19 vaccination in immunosuppressed patients

SARS-CoV-2 Omicron variant's infectivity, vaccine breakthrough, and antibody resistance

SARS-CoV-2 omicron variant predicted to cause fewer deaths in Florida

SARS-CoV-2 shown to spread through cell-to-cell transmission

Declining effectiveness of the BNT162b2 vaccine in adolescents infected with COVID-19

SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

Association of vaccination status with Long COVID symptoms

Researchers plan to review the effect of SARS-CoV-2 on male reproductive health

Strategy for capturing SARS-CoV-2 through functionalized cellulose materials

SARS-CoV-2 Delta sublineage AY.4.2 shows no increase in cell entry or antibody evasion

New lab-on-a-chip platform for detecting SARS-CoV-2 in resource-limited settings

History of SARS-CoV-2 infection affects longitudinal responses to BNT162b2 vaccine

Influenza vaccination does not affect risk of SARS-CoV-2 infection or COVID-19

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