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Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by targeting immunosuppressive dendritic cells

This new article publication from Acta Pharmaceutica Sinica B, discusses how single-cell RNA sequencing reveals that Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131-TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells.

12 Jul 2025

New insights into how cells silence dangerous genomic elements

An international research team led by Freiburg biologists Dr. Wenjing Qi and Prof. Ralf Baumeister has discovered how the LINE1 retrotransposon exploits a cell protein to become active itself, as occurs in tumors.

12 Jul 2025

WHO maintains global emergency status for mpox following June 2025 IHR Emergency Committee meeting

The Director-General of the World Health Organization (WHO) is hereby transmitting the report of the fourth meeting of the International Health Regulations (2005) (IHR) Emergency Committee (Committee) regarding the upsurge of mpox 2024, held on Thursday, 5 June 2025, from 12:00 to 17:00 CEST.

12 Jul 2025

AlphaFold2 enables large scale analysis of enzyme evolution

Enzymes catalyze chemical reactions in organisms - without which life would not be possible. Leveraging AlphaFold2 artificial intelligence, researchers at Charité – Universitätsmedizin Berlin have now succeeded in analyzing the laws of their evolution on a large scale.

10 Jul 2025

Australian scientists use AI to create protein that kills superbugs

In the last year, there has been a surge in proteins developed by AI that will eventually be used in the treatment of everything from snakebites to cancer. What would normally take decades for a scientist to create – a custom-made protein for a particular disease – can now be done in seconds.

9 Jul 2025

Understanding the human brain architecture through gene coexpression analysis

In a comprehensive Genomic Press Interview published in Brain Medicine, Dr. Michael C. Oldham shares his unconventional journey from advertising executive to computational neuroscientist and his groundbreaking contributions to understanding the human brain's cellular and molecular architecture through gene coexpression analysis.

8 Jul 2025

Smallest known protein-based enzyme HARP reveals dual role in tRNA processing

To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where they read the genetic instructions from messenger RNA, mRNA, and deliver the right amino acids to ribosomes, the cell's protein-making factories.

7 Jul 2025

New AI-informed method accelerates protein engineering

A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences has developed a groundbreaking method that could transform the field of protein engineering.

7 Jul 2025

Unlocking the brain’s language to fight Alzheimer’s

June is Alzheimer's and Brain Awareness Month. With an estimated 55 million people living with Alzheimer's Disease and other forms of dementia worldwide, advancing understanding of these complex diseases is critical to finding new treatments, and potentially, cures.

7 Jul 2025

Synthetic Biology and the Pursuit of Living Diagnostics and Therapeutics

In this interview, Professor James J. Collins, founder of the field of Synthetic Biology, discusses his journey to founding the field of synthetic biology and the potential of living diagnostics.

From Pittcon 7 Jul 2025

Biosynth expands Berlin site with a new commercial bioconjugation suite

Biosynth, a leading developer and supplier of critical raw materials and services for life sciences and diagnostics, is pleased to announce the opening of its expanded GMP bioconjugation facility at its existing Berlin site.

7 Jul 2025

Mitochondria depletion in stem cells offers insights into cellular energy and evolution

By using a genetic technique developed at UT Southwestern Medical Center that forces cells to rid themselves of mitochondria, researchers are gaining new insights into the function of these critical organelles.

7 Jul 2025

Study uncovers the molecular evolutionary strategies of the OxPhos system

Mitochondria are the body's "energy factories," and their proper function is essential for life. Inside mitochondria, a set of complexes called the oxidative phosphorylation (OxPhos) system acts like a biochemical assembly line, transforming oxygen and nutrients into usable energy.

4 Jul 2025

New insights into nature's most remarkable innovation- the ability to sustain a successful pregnancy

An international research team led by scientists from the University of Vienna has uncovered new insights into how specialized cell types and communication networks at the interface between mother and fetus evolved over millions of years.

4 Jul 2025

The clever ways Neanderthals got their fat long before modern humans

Neanderthals at Neumark-Nord, Germany, systematically transported and processed the bones of at least 172 large mammals to extract nutrient-rich "bone grease" nearly 125,000 years ago. This finding rewrites the timeline for large-scale fat processing, revealing unexpectedly complex resource strategies among Neanderthals.

3 Jul 2025

Hepatitis E virus also attacks organs other than the liver, study finds

A research team from Bochum and Hannover shows that the hepatitis E virus also attacks organs other than the liver.

3 Jul 2025

Scientists reveal how chemotherapy causes genetic damage in healthy blood

For the first time, scientists have systematically studied the genetic effects of chemotherapy on healthy tissues.

2 Jul 2025

Researchers find gut bacteria rapidly soak up ‘forever chemicals’

Scientists have demonstrated that select human gut bacteria can bioaccumulate and sequester PFAS ‘forever chemicals’, increasing faecal excretion in humanized mice. The findings reveal a potential microbiome-based strategy to reduce PFAS body burden, though clinical benefit in humans remains unproven.

1 Jul 2025

Scientists trace leprosy’s roots in South America back 4,000 years

Researchers have recovered and sequenced Mycobacterium lepromatosis genomes from 4,000-year-old human remains in Chile, providing the first molecular evidence of ancient leprosy in the Americas. The findings reveal the deep evolutionary roots and complex spread of Hansen’s disease long before European contact.

1 Jul 2025

Macrophage-derived lipocalin 2 drives severe pneumonia in SARS-CoV-2 infection

Since the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), understanding the mechanisms underlying severe pneumonia has remained a major research challenge.

1 Jul 2025