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RNA nanoparticles offer dual action against prostate tumors

Yang Zhang, PhD, and Jinjun Shi, PhD, both of the Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women's Hospital, are co-senior authors of a paper published in ACS Nanoscience Au, "Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer."

10 Jan 2025

Researchers identify shared genes driving cancer spread

Cancer metastasis-the spread of cancer to other organs-is the leading cause of death among cancer patients. Researchers have now uncovered a "genetic signature" of 177 genes shared across multiple cancer types that drives this deadly process.

10 Jan 2025

New AI method predicts gene activity in human cells

Using a new artificial intelligence method, researchers at Columbia University Vagelos College of Physicians and Surgeons can accurately predict the activity of genes within any human cell, essentially revealing the cell's inner mechanisms.

8 Jan 2025

Hidden culprit: Human metapneumovirus identified in severe adult pneumonia case

Severe pneumonia caused by human metapneumovirus in an immunocompetent adult highlights diagnostic challenges and underscores the need for rapid molecular diagnostics to improve outcomes.

6 Jan 2025

Novel hMPV strains linked to rising respiratory infections in young children

Researchers in India discovered novel hMPV lineages A2.2.1 and A2.2.2, emphasizing their role in pediatric respiratory infections and potential public health implications.

6 Jan 2025

Investigating the impact of CircRNAs on cancer progression and drug resistance

The researcher has given an overview on the regulatory network of extracellular circRNAs in cancer and their impact on cancer drug resistance.

6 Jan 2025

Rice researchers develop new construction kit for engineering smart cells

Rice University bioengineers have developed a new construction kit for building custom sense-and-respond circuits in human cells.

3 Jan 2025

KFF Health News' 'What the Health?': Francis Collins on supporting NIH and finding common ground

This week, KFF Health News' "What the Health?" presents a conversation with Francis Collins, former National Institutes of Health director and White House science adviser.

2 Jan 2025

Scientists pinpoint regions and species fueling coronavirus evolution in bats

Study uncovers the evolution, transmission, and geographic spread of bat coronaviruses in China, revealing key insights into hotspots and the origins of SARS-CoV-2.

1 Jan 2025

Lithocholic acid enhances health and lifespan, mimicking calorie restriction

Lithocholic acid (LCA), a metabolite induced by calorie restriction (CR), activates AMPK and mimics anti-aging benefits. A recent study highlights LCA's role in improving muscle performance, glucose tolerance, and lifespan in aged organisms.

1 Jan 2025

Linker histones found to regulate DNA transcription in apple cells

A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA transcription into RNA – the first step of the process by which an organism's genetic code expresses itself.

23 Dec 2024

Long-term green tea catechins prevent aging-related cardiac dysfunction

A new publication from Genes & Diseases; DOI 10.1016/j.gendis.2024.101284, discusses the effect of long-term administration of green tea catechins on aging-related cardiac diastolic dysfunction and decline of troponin I.

20 Dec 2024

A new link between brain health and mitochondrial function

New findings in mice have uncovered a crucial mechanism linking neuronal activity to mitochondrial function, researchers report, revealing a potential pathway to combat age-related cognitive decline. Mitochondria play a pivotal role in meeting the dynamic energy demands of neuronal activity, producing adenosine triphosphate (ATP) primarily via oxidative phosphorylation (OXPHOS).

19 Dec 2024