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Majority of gene faults not shared across other biopsies from same tumour

Taking a sample from just one part of a tumour may not give a full picture of its 'genetic landscape', according to a landmark study published in the New England Journal of Medicine.

2 May 2012

Breast-fed babies may have healthy gut microbial population

Early colonization of the gut by microbes in infants is critical for development of their intestinal tract and in immune development. A new study, published in BioMed Central's open access journal Genome Biology, shows that differences in bacterial colonization of formula-fed and breast-fed babies leads to changes in the infant's expression of genes involved in the immune system, and in defense against pathogens.

30 Apr 2012

Detrimental effect of tetracycline on male reproductive function, sperm viability of pseudoscorpions

In a paper published today in Nature's open access journal Scientific Reports, researchers at the University of Nevada, Reno report that male pseudoscorpions treated with the antibiotic tetracycline suffer significantly reduced sperm viability and pass this toxic effect on to their untreated sons. They suggest that a similar effect could occur in humans and other species.

30 Apr 2012

Gas NO plays a fundamental regulatory role in controlling bacterial function

Bacteria provide a well-known playground for scientists and the evolution of these earliest life forms has shed important perspective on potential therapies for some of the most common, deadly diseases. Researchers at Case Western Reserve University School of Medicine have now discovered that, the gas nitric oxide (NO), produced in all cells of the human body for natural purposes, plays a fundamental regulatory role in controlling bacterial function, via a signaling mechanism called S-nitrosylation (SNO), which binds NO to protein molecules.

27 Apr 2012

Seabirds play an important role in dispersal and biodiversity of parasites

According to a scientific paper published in the journal Biology Letters, in which have taken part Jacob González-Solís, professor at the Department of Animal Biology and at the Biodiversity Research Institute of the University of Barcelona (IRBio), due to their capacity to travel long distances, seabirds play an important role in the dispersal and biodiversity of parasites and of the infectious agents these may transmit.

27 Apr 2012

AAA to gather for anatomy meeting in conjunction with Experimental Biology 2012

The American Association of Anatomists will gather this week for its annual meeting in conjunction with the Experimental Biology 2012 conference, which will draw more than 14,000 scientists from industry, government and academia. Below are some programming highlights for the anatomy meeting. All presentations will be made at the San Diego Convention Center.

26 Apr 2012

Laws against cousin marriage are not supported by science: New book

The health risks of marrying a cousin have been grossly overstated, says a new book. A better understanding of the health effects of cousin marriage could mean more appropriate marriage laws and better medical care for cousin couples and their children.

26 Apr 2012

Body’s own DNA can cause inflammation in the heart

DNA from the heart's own cells plays a role in heart failure by mistakenly activating the body's immune system, according to a study by British and Japanese researchers, co-funded by the British Heart Foundation.

26 Apr 2012

Self-degradation response to antidepressant Zoloft observed in yeast cells

Princeton University researchers have observed a self-degradation response to the antidepressant Zoloft in yeast cells that could help provide new answers to lingering questions among scientists about how antidepressants work, as well as support the idea that depression is not solely linked to the neurotransmitter serotonin.

25 Apr 2012

Codexis receives FDA approval for sitagliptin manufacturing process

Codexis, Inc., a developer of industrial enzymes to enable the cost advantaged production of biofuels, bio-based chemicals, and pharmaceutical intermediates, today announced that the FDA has approved a new process co-developed by Codexis for the manufacture of sitagliptin, the active pharmaceutical ingredient in Merck's Januvia.

25 Apr 2012

Robot-assisted surgery more common and successful in treating prostate cancer

Robot-assisted surgery is now both more common and far more successful than radical "open" surgery to treat prostate cancer in the United States, according to a new Henry Ford Hospital study published in the current issue of the medical journal European Urology.

24 Apr 2012

Avocado oil protects against free radicals in mitochondria

Atmospheric oxygen facilitated the evolution and complexity of terrestrial organisms, including human beings, because it allowed nutrients to be used more efficiently by those organisms, which in turn were able to generate more energy. However, as we find out more about how oxygen molecules work inside the body, more attention is being paid to their not-so-good effects, and researchers are seeking ways to thwart them.

23 Apr 2012

New data shows consolidation of interferon-free revolution in HCV treatment

New data presented at the International Liver Congress 2012 shows consolidation of the interferon-free (IFN) revolution in HCV treatment. The much anticipated data from a number of clinical trials confirm that combinations of antivirals offer the hope of shorter, more effective treatment with fewer side effects.

20 Apr 2012

Connection between eating meat and faster weaning process

Carnivory is behind the evolutionary success of humankind. When early humans started to eat meat and eventually hunt, their new, higher-quality diet meant that women could wean their children earlier. Women could then give birth to more children during their reproductive life, which is a possible contribution to the population gradually spreading over the world.

20 Apr 2012

First neurobiological model for third-party punishment

In a paper published online on April 15 by the journal Nature Neuroscience, a pair of neuroscientists from Vanderbilt and Harvard universities has proposed the first neurobiological model for third-party punishment. It outlines a collection of potential cognitive and brain processes that evolutionary pressures could have re-purposed to make this behavior possible.

19 Apr 2012

Morphotek commences MORAb-004 Phase II study in metastatic colorectal cancer

Morphotek, Inc., a subsidiary of Eisai Inc., announced today that it has commenced a multi-center, Phase II study evaluating the safety and efficacy of MORAb-004 in the treatment of metastatic colorectal cancer that is refractory to all standard therapy.

17 Apr 2012

Gene function preserved despite structural differences in the DNA

Chloroplasts, the plant cell's green solar power generators, were once living beings in their own right. This changed about one billion years ago, when they were swallowed up but not digested by larger cells. Since then, they have lost much of their autonomy.

16 Apr 2012

Study examines cellular and molecular organization of human and mouse brain

Scientists at the Allen Institute for Brain Science have identified similarities and differences among regions of the human brain, among the brains of human individuals, and between humans and mice by analyzing the expression of approximately 1,000 genes in the brain.

16 Apr 2012

Missing tool helps sperm and eggs develop exactly 23 chromosomes each

Researchers at the University of California, Davis have discovered a key tool that helps sperm and eggs develop exactly 23 chromosomes each. The work, which could lead to insights into fertility, spontaneous miscarriages, cancer and developmental disorders, is published April 13 in the journal Cell.

16 Apr 2012

Researchers discover intra-cellular function of LOXL2 protein

Researchers at the Hospital de Mar Research Institute (IMIM) have discovered that the protein LOXL2 has a function within the cell nucleus thus far unknown. They have also described a new chemical reaction of this protein on histone H3 that would be involved in gene silencing, one of which would be involved in the progression of breast, larynx, lung and skin tumours.

16 Apr 2012