Small Intestine News and Research

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Nanocellulose fibers can reduce fat absorption, research finds

A novel method of reducing the absorption of fat from the gut has recently been granted a US provisional patent. Researchers have demonstrated that the addition of nanocellulose fibres to the food of animals significantly reduces the amount of ingested fat that reaches the bloodstream.

8 Aug 2018

Access to soil increases mice's resistance to allergic inflammations

When mice live in cages with an added earthen floor, it increases their resistance towards allergic inflammations. Close contact with micro-organisms in the soil triggers anti-inflammatory genes in the mice and stimulates their gut microbiota.

7 Aug 2018

Probiotic use could result in disorienting brain fogginess and rapid belly bloating

Probiotic use can result in a significant accumulation of bacteria in the small intestine that can result in disorienting brain fogginess as well as rapid, significant belly bloating, investigators report.

6 Aug 2018

Digestive hormone influences pancreatic cancer growth and spread

A high-fat diet may promote the growth of pancreatic cancer independent of obesity because of the interaction between dietary fat and cholecystokinin, a digestive hormone.

3 Aug 2018

Scientists map regulatory landscape of mouse genome at single-cell resolution

Scientists have completed a major effort to map the regulatory landscape of the mouse genome at a single-cell resolution.

2 Aug 2018

Researchers discover key piece for slowing colorectal cancer subtype

Inhibiting the Jagged 1 protein in mice prevents the proliferation and growth of colon and rectal tumors. What is more, this approach to the disease permits the removal of existing tumors.

2 Aug 2018

Bile acids from the gut may offer new treatment for cocaine abuse

Bile acids that aid fat digestion are also found to reduce the rewarding properties of cocaine use, according to a study publishing on July 26 in the open-access journal PLOS Biology by India Reddy, Nicholas Smith, and Robb Flynn of Vanderbilt University, Aurelio Galli of the University of Alabama at Birmingham, and colleagues.

27 Jul 2018

PureTech Health collaborates with Roche to advance oral administration of antisense oligonucleotides

PureTech Health plc, a clinical-stage biopharmaceutical company developing novel medicines focused on the Brain-Immune-Gut Axis, today announced that it has entered into a multiyear collaboration with F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc., to advance PureTech's milk-derived exosome platform technology for the oral administration of Roche's antisense oligonucleotide platform.

20 Jul 2018

Researchers discover immune cells that create and sustain chronic inflammatory bowel disease

In preclinical experiments, Laurie Harrington, Ph.D., and colleagues at the University of Alabama at Birmingham have discovered a subset of immune cells that create and sustain chronic inflammatory bowel disease.

27 Jun 2018

New FDA-approved therapy provides better quality of life for patients with midgut neuroendocrine tumors

Midgut neuroendocrine tumors are a rare type of cancer that develops in the small intestine and colon. Roughly 12,000 people are diagnosed with this disease each year. In January, the United Stated Food and Drug Administration approved Lutathera, a first-of-its-kind peptide receptor radionuclide therapy.

12 Jun 2018

Researchers develop 'surgery in a pill' to reverse type 2 diabetes

Over the last decade, bariatric surgeons have made strides in performing weight loss surgery that not only reverses obesity but can also reverse type 2 diabetes in patients with both conditions.

11 Jun 2018

Cedars-Sinai study identifies gut gas associated with diarrhea

Cedars-Sinai investigators have for the first time identified a gas produced in gut that could improve the diagnosis and treatment of patients with two common intestinal illnesses - small intestine bacterial overgrowth and irritable bowel syndrome.

6 Jun 2018

Opdivo plus low-dose Yervoy shows promising results in treating renal cell carcinoma patients

Bristol-Myers Squibb Company today announced patient-reported outcomes data from the Phase 3 CheckMate -214 trial in intermediate- and poor-risk patients with advanced renal cell carcinoma treated with the Immuno-Oncology combination Opdivo plus low-dose Yervoy versus sunitinib over a two-year follow-up period.

1 Jun 2018

FDA authorizes marketing of Hemospray device for treating GI bleeding

Today, the U.S. Food and Drug Administration permitted marketing of Hemospray, a new device used to help control certain types of bleeding in the gastrointestinal (GI) tract.

8 May 2018

University of Pennsylvania expert investigates novel treatment for cocaine addiction

Cocaine and other drugs of abuse hijack the natural reward circuits in the brain. In part, that's why it's so hard to quit using these substances.

28 Apr 2018

Western diets promote bacterial growth in the small intestine, increase fat digestion and absorption

A researcher at Midwestern University led a new study showing that Western diets, high in fat and simple sugar, promote the growth of bacteria in the small intestine that increase fat digestion and absorption.

27 Apr 2018

Researchers target and kill disease-causing bacteria using cocktail of viruses

Imagine that you have become ill because you have eaten some food that contained pathogenic bacteria. You keep running to the toilet and you may also throw up. You go to the doctor and are prescribed broad-spectrum antibiotics, which - in addition to killing the bad bacteria in your intestinal flora - carpet bomb the complex community of commensal bacteria forming a healthy intestinal flora.

26 Apr 2018

UA researchers aim to predict and prevent fatal disease in premature babies

A new $1.9 million grant at the University of Arizona Steele Children's Research Center will help researchers discover ways to prevent a deadly disease that affects thousands of premature infants annually.

25 Apr 2018

'Gut-on-a-chip' model recreates intestinal matrix critical for nutrient absorption

The difficulties of conducting research on the human gut are substantial: the presence of trillions of bacterial cells interacting with human cells and each other, constant environmental changes every time food is consumed and zero chance of conducting trials that control for all those moving parts.

18 Apr 2018

Specific small-bowel microbes regulate digestion and absorption of fats, study shows

Although the vast majority of research on the gut microbiome has focused on bacteria in the large intestine, a new study - one of a few to concentrate on microbes in the upper gastrointestinal tract - shows how the typical calorie-dense western diet can induce expansion of microbes that promote the digestion and absorption of high-fat foods.

11 Apr 2018