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Scientists solve structure of gene regulator that plays key role in cancer

Scientists at The Wistar Institute have collaborated on a major advance in understanding a gene regulator that contributes to some of the deadliest cancers in humans.

14 Feb 2008

Location location location, even for genes

Moving an active gene from the interior of the nucleus to its periphery can inactivate that gene report scientists from the University of Chicago Medical Center in an article to be published early online Feb.13, 2008, in the journal Nature.

14 Feb 2008

Gene regulators bind promiscuously, but often do nothing

Biologists are developing ever more sophisticated means to characterize molecular interactions in living systems.

13 Feb 2008

MIT applies engineering approach to studying biological pathways

An MIT team has used an engineering approach to show that complex biological systems can be studied with simple models developed by measuring what goes into and out of the system.

7 Feb 2008

Disrupted genetic regulation causes common disturbance in metabolism of fat

The disease familial combined hyperlipidemia (FCH) is a common cause of disturbed metabolism of fat and early heart attacks.

7 Feb 2008

Disrupted genetic regulation causes common disturbance in metabolism of fat

The disease familial combined hyperlipidemia (FCH) is a common cause of disturbed metabolism of fat and early heart attacks.

5 Feb 2008

Why your fertility cells must have 'radio silence'

Researchers in Kobe, Japan, and Montreal, Canada, have uncovered a previously unknown mechanism which causes embryonic germ cells which later develop into sperm or ova to go through a period of "transcriptional silence," during which information from the cell's DNA cannot be copied.

31 Jan 2008

Protein that controls hair growth also keeps stem cells slumbering

Like fine china and crystal, which tend to be used sparingly, stem cells divide infrequently.

25 Jan 2008

Cigarettes leave deadly path by purging protective genes

A University of Rochester scientist discovered that the toxins in cigarette smoke wipe out a gene that plays a vital role in protecting the body from the effects of premature aging.

24 Jan 2008

Smoking wipes out protective genes

A University of Rochester scientist discovered that the toxins in cigarette smoke wipe out a gene that plays a vital role in protecting the body from the effects of premature aging.

21 Jan 2008

Scientists uncover role of cancer stem cell marker: controlling gene expression

Scientists at Jefferson's Kimmel Cancer Center in Philadelphia have made an extraordinary advance in the understanding of the function of a gene previously shown to be part of an 11-gene "signature" that can predict which tumors will be aggressive and likely to spread.

18 Jan 2008

Cancer stem cell marker also drives transcription in normal cells

New research links the recently discovered function of a multi-faceted transcriptional complex to control of gene expression in both normal cells and cancer stem cells.

18 Jan 2008

New clues about BRCA1 role in breast cancer

A breast cancer gene's newly discovered role in repairing damaged DNA may help explain why women who inherit a mutated copy of the gene are at increased risk for developing both breast and ovarian cancer.

17 Jan 2008

Researchers find cell protein that blocks HIV virus generation

UCLA researchers have found that a key protein in the body's dendritic cells can stop the virus that causes AIDS from "budding" part of the virus' life cycle that is crucial to its ability to replicate and infect other cells.

16 Jan 2008

Molecular evolution of limb length

In the January 15th issue of G&D, a research team led by Dr. Richard Behringer at MD Anderson Cancer Center reports that they have successfully switched the mouse Prx1 gene regulatory element with the Prx1 gene regulatory region from a bat - and although these two species are separated by millions of years of evolution - the resulting transgenic mice displayed abnormally long forelimbs.

15 Jan 2008

microRNA molecules block breast cancer's ability to spread

Researchers have identified a specific group of microRNA molecules that are responsible for controlling genes that cause breast cancer metastasis.

10 Jan 2008

Evolution of the sexes: What a fungus can tell us

Fungi don't exactly come in boy and girl varieties, but they do have sex differences.

10 Jan 2008

New understanding on the mechanics of gene transcription

The molecular machinery behind gene transcription -- the intricate transfer of information from a segment of DNA to a corresponding strand of messenger RNA -- isn't stationed in special "transcription factories" within a cell nucleus, according to Cornell researchers.

9 Jan 2008

Two genes are important key to regulating immune response

A research team at Weill Cornell Medical College in New York City has identified two genes that may be crucial to the production of an immune system cytokine called interleukin-10 (IL-10)

2 Jan 2008

Model developed that predicts molecular response of living cells to genetic or environmental change

Scientists at the Institute for Systems Biology (ISB), in collaboration with researchers from New York University (NYU), have developed a model which rapidly characterizes and accurately predicts the molecular-level, mechanistic response of a free-living cell to genetic and environmental changes.

28 Dec 2007