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TFAP2C gene may be useful target for new breast cancer therapies

University of Iowa researchers have discovered a gene that plays a linchpin role in the ability of breast cancer cells to respond to estrogen.

17 Sep 2007

Novel mechanism discovered that balances the sizes of functional areas in the brain

In the cerebral cortex, the brain's powerful central processing unit responsible for higher functions, specialized subdivisions known as areas are laid out like a map, but little is known about the genetic forces that shape the geography of our brains.

11 Sep 2007

Research looks at prions and retroviruses

National Research Center for Environment and Health in Neuherberg/Munich (Helmholtz Association of German Research Centres) the group is continuing to search for cellular components whose make-up is changed as a result of a prion infection.

10 Sep 2007

Bad news for disease-causing bacteria!

Scientists have what could be some very bad news for disease-causing bacteria. All three major classes of antibiotics that kill infectious bacteria do so in part by ramping up the production of harmful free radicals, researchers report in the September 7, 2007, issue of Cell, a publication of Cell Press.

10 Sep 2007

Flies can turn off their immune response

The immune response is actively turned on to target and destroy foreign infectious elements, but in the interests of self-preservation, it is just as important to turn the immune system off to avoid damage to oneself by "friendly fire."

4 Sep 2007

Gene regulation in humans is closer than expected to simple organisms

Gene networks are some of the most basic features of a living organism. An external or internal stimulus activates some genes, which in turn control others genes whose activity turns on or off various biological processes (such as the cell cycle, energy production, DNA repair, cellular suicide etc).

30 Aug 2007

New understanding of factor YY1 in gene expression

The Conaway Lab - led by Joan Conaway, Ph.D., and Ron Conaway, Ph.D., Investigators - has published findings that shed light on the role of the much-studied transcription factor YY1 in gene expression.

28 Aug 2007

New Cockayne syndrome discovery

Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have shown that the genetic defect that causes Cockayne Syndrome affects a key function of the cell – the transcription of genes coding for ribosomal RNA.

21 Aug 2007

Reactivating a critical gene lost in kidney cancer reduces tumor growth

Researchers at Mayo Clinic Jacksonville, have found that a key gene is often silenced in clear cell renal cell carcinoma, the most common type of kidney cancer, and when they restored that gene in human kidney cancer cells in culture and animal experiments, tumors stopped growing and many disappeared.

17 Aug 2007

Sirtuin protein instrumental in fat production and metabolism

A new Joslin Diabetes Center-led study has identified a protein found in fat cells that may play a major role in how fat is produced and stored, offering a new target for treatments to prevent obesity and reduce the risk for type 2 diabetes.

17 Aug 2007

Discovery of new mechanism of resistance to endocrine or anti-hormonal therapies

When a woman receives a breast cancer diagnosis her entire life may change in the blink of an eye.

13 Aug 2007

Neuregulin 1 gene linked to schizophrenia

Scientists have provided new insight into how a gene is related to schizophrenia.

12 Aug 2007

Researchers discover how Bcl-3 protein stops inflammation

Researchers at the University of Pennsylvania School of Medicine recently identified how a regulatory protein called Bcl-3 helps to control the body's inflammation response to infection by interfering a critical biochemical process called ubiquitination.

12 Aug 2007

Chromatin remodeling complex connected to DNA damage control

When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at The University of Texas M. D. Anderson Cancer Center report in the August edition of Cell.

12 Aug 2007

Gene regulation drives evolution

It is not just what's in your genes, it's how you turn them on that accounts for the difference between species , at least in yeast , according to a report by Yale researchers in this week's issue of Science.

11 Aug 2007

Bcl-3 protein regulates inflammation by blocking ubiquitination

8 Aug 2007

New research may lead to future gene therapies for patients with sickle cell anemia and beta-thalassemia

Virginia Commonwealth University researchers studying hemoglobin genes, mutations of which play a role in genetic blood disorders like sickle cell anemia and beta-thalassemia, have identified two proteins that are responsible for regulating overlapping groups of genes during the development of red blood cells.

7 Aug 2007