Transcription News and Research

RSS

Huntington's disease study shows animal models on target

An international team of researchers has published a benchmark study showing that gene expression in several animal models of Huntington's Disease (HD) closely resembles that of human HD patients.

1 Aug 2007

Researchers genetically modify a plant to halt reproduction of HIV related virus

In a study that could lead to new ways to prevent infection by human immunodeficiency virus (HIV) and similar organisms, Purdue University researchers have been able to genetically modify a plant to halt reproduction of a related virus.

31 Jul 2007

Researchers watch bacteria and antibiotics at the atomic level

A new understanding of an enzyme important for the transfer of genetic information in bacteria may help scientists improve current antibiotics and also create antibiotics that are less vulnerable to resistance.

27 Jul 2007

New findings on gene-transcription machinery

For some time, scientists have been tracking down the sequence of biochemical steps required to attract and assemble at the head end of a gene the molecular machinery needed to transcribe that gene to put to work the information it encodes.

26 Jul 2007

New gene therapy for 200 inherited forms of blindness

An improved approach to gene therapy may one day treat some of the nearly 200 inherited forms of blindness, scientists at Washington University School of Medicine in St. Louis suggest.

26 Jul 2007

Powerful proteomics research promises to revolutionize biomedical discovery

Human cells function through the concerted action of thousands of proteins that control their growth and differentiation.

20 Jul 2007

Researchers identify gene-regulating protein in the brain that triggers ability to cope with

Researchers have identified a gene-regulating protein in the brains of mice that triggers the animals' ability to cope with the "behavioral despair" caused by inescapable stress.

19 Jul 2007

Plumber protein uses different tools to turn on genes

St. Jude investigators have discovered how a single molecular "on switch" triggers gene activity that might cause effects ranging from learning and memory capabilities to glucose production in the liver.

18 Jul 2007

Scientists discover human genes hover between "on"and "off" in any given cell

Biologists have long thought that a simple on/off switch controls most genes in human cells.

13 Jul 2007

Magnetic nano tweezers show how cancer drug works

The annoying bulges of an over-wound telephone cord that shorten its reach and limit a caller's motion help to explain why drugs called camptothecins are so effective in killing cancer cells, according to investigators at St. Jude Children's Research Hospital and Delft University of Technology.

10 Jul 2007

New insights into acute promyelocytic leukemia

Results from two new studies provide key mechanistic insights into the complex molecular events that cause a deadly type of leukemia.

10 Jul 2007

Biomira files NDA for novel inhibitor of hypoxia-inducible factor-1 alpha

Biomira Inc. has announced that it has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration for PX-478. PX-478 has been shown in preclinical studies to inhibit hypoxia-inducible factor (HIF)-1 alpha, a protein that controls the transcription of a number of genes whose products are important for tumor growth and survival.

4 Jul 2007

Physician order entry system reduces error

The incidence of medication errors can be reduced by implementing a computerized physician order entry (CPOE) system, according to a review of several studies conducted by researchers at the University of Minnesota.

28 Jun 2007

New type of mouse embryonic stem cell discovered

Scientists have discovered a new type of mouse embryonic stem cell that is the closest counterpart yet to human embryonic stem (ES) cells, the National Institutes of Health (NIH) have announced.

28 Jun 2007

Scientists discover role of ataxia telangiectasia mutated protein in DNA repair

Scientists from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Cancer Institute (NCI), and Integrative Bioinformatics Inc. have made an important discovery about the role of an enzyme called ataxia telangiectasia mutated protein (ATM) in the body's ability to repair damaged DNA.

28 Jun 2007

Electronics to the rescue of sloppy doctors

Doctors are famous for sloppy scribbling - and handwritten prescriptions lead to thousands of medication errors each year.

28 Jun 2007

Genes play unexpected role in their own activation

Investigators at St. Jude Children's Research Hospital have discovered how a single molecular "on switch" triggers gene activity that might cause effects ranging from learning and memory capabilities to glucose production in the liver.

23 Jun 2007

Medical error is the fifth-leading cause of death in the U.S.

Millennium Research Group (MRG) has conducted a detailed and thorough analysis of the acute care clinical information systems (CIS) market and finds that a major driver in the US is the demand for improvement in patient safety.

23 Jun 2007

Key mechanism identified by which the body regulates iron metabolism

Scientists at the University of California, San Diego (UCSD) have determined a key mechanism by which the body regulates iron metabolism, a discovery that may provide new approaches for the treatment of anemia.

23 Jun 2007

Gamma-secretase acts as a tumor suppressor

Researchers at Burnham Institute for Medical Research (Burnham) have provided the first evidence that gamma-secretase, an enzyme key to the progression of Alzheimer's, acts as a tumor suppressor by altering the pathway of epidermal growth factor receptor (EGFR), a potential treatment target for cancer.

14 Jun 2007