Neurodegeneration News and Research

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Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons.

Investigational drug ameliorates neuronal DNA damage and inflammation in Alzheimer's model

Accumulation of DNA damage in the brain's neurons may contribute to the development of Alzheimer's disease.

8 Jul 2026

New review shows why antidepressants often fail in Alzheimer’s and Parkinson’s depression

A Molecular Psychiatry review shows that depression in Alzheimer’s and Parkinson’s disease may reflect disease-specific molecular, neurotransmitter, inflammatory, and circuit-level disruptions rather than standard depression biology alone. It argues that broad antidepressants often show limited efficacy in these patients and that future trials should use biomarkers, neuroimaging, and symptom profiling to guide targeted treatments.

7 Jul 2026

Study offers insight into how long-term inflammation may contribute to cognitive decline

The King's College London study, published in Nature Communications, offers insight into how long-term inflammation may contribute to cognitive decline in disorders such as Alzheimer's disease, aging, depression, and the lingering neurological effects of viral infections.

7 Jul 2026

Study identifies promising drug target to prevent neurodegenerative conditions

Parkinson's disease (PD) is the second most common form of neurodegenerative disease and afflicts more than ten million people worldwide. While current therapies address disease symptoms, they do not prevent the underlying neurodegeneration that drives the disease.

6 Jul 2026

Study provides new insights into biological processes linked to Huntington’s disease

A study conducted by the Sant Pau Research Institute (IR Sant Pau) and Hospital de Sant Pau has identified for the first time in living individuals a brain pattern related to the tau protein that changes according to the stage of Huntington's disease.

6 Jul 2026

BCG vaccine may remodel the human brain's immune environment

New research led by Mass General Brigham investigators suggests that the Bacillus Calmette-Guérin (BCG) vaccine - which is delivered through the skin to prevent tuberculosis - may remodel the human brain's immune environment, offering a potential biological explanation for previously observed associations between BCG vaccination and lower Alzheimer's disease risk.

6 Jul 2026

Alzheimer’s disease biomarkers predict rapid cognitive decline in very old adults

Cognitive decline in very old adults has been considered for decades to be an almost inevitable consequence of aging.

1 Jul 2026

Blood biomarker may predict Alzheimer's progression differently in men

A blood test does not lie, exactly. It reports a number. The question raised by a new mini-review in Brain Medicine, which gathers and weighs a decade of scattered findings, is whether clinicians have been reading the same number in two different ways without realizing it.

30 Jun 2026

Niigata University study updates Alzheimer's risk for APOE-e4 homozygotes

Researchers at Niigata University have conducted the first comprehensive reappraisal in nearly 30 years of the risk of Alzheimer's disease (AD) associated with APOE-e4 homozygosity (e4*4) in the Japanese population.

30 Jun 2026

Blood metabolism maps how lifestyle tracks function in cognitive aging

A new study used pathway-level blood metabolomics to identify lifestyle-associated metabolic patterns linked to physical, cognitive, and daily functional performance across CN, MCI, and AD. The findings suggest that diet- and activity-linked pathway signals span energy, amino acid, lipid, inflammatory, oxidative stress, and microbiome-related metabolism, but require independent and longitudinal validation.

29 Jun 2026

Longer hormone exposure linked to healthier brain aging in women

Research indicates that hormonal therapies and later menopause are associated with increased brain volume and thickness, promoting healthier aging.

26 Jun 2026

Iron overload gradually increases neurons' vulnerability to neurodegeneration

Neurodegenerative diseases affect tens of millions of people worldwide. Among these, Alzheimer's and Parkinson's diseases are the most common; in the United States alone, the Alzheimer's Disease Association and Parkinson's Foundation report roughly 7 million people with Alzheimer's and another million with Parkinson's.

25 Jun 2026

Peacemaker immune cells offer new hope for restoring immune tolerance

'Peacemaker' immune cells could help treat diseases ranging from type 1 diabetes to neurodegeneration by restoring immune tolerance, according to a new paper in Frontiers in Science.

25 Jun 2026

Discovery of karyoptosis opens new therapeutic targets for Alzheimer's and frontotemporal dementia

Markers of a new mechanism for cell death, called karyoptosis, have been found in brains of patients with Alzheimer's disease and frontotemporal dementia (FTD).

25 Jun 2026

High-dose DHA reaches the brain but fails to protect memory

High-dose DHA effectively increased brain levels in older adults at Alzheimer's risk, but did not lead to cognitive or structural brain health improvements.

25 Jun 2026

Researchers identify molecular cause of age-related cognitive decline

A research team from University Hospitals, Case Western Reserve University and the Louis Stokes Cleveland VA Medical Center has identified a critical molecular cause of age-related cognitive decline, potentially paving the way for new treatments to protect brain health as we age.

23 Jun 2026

Pheno Therapeutics granted FDA IND clearance for lead multiple sclerosis therapeutic candidate PTD802

Pheno Therapeutics Limited. (Pheno), a clinical stage biotechnology company focused on the discovery and development of small molecule therapeutics for the treatment of neurological diseases, today announced that the US Food and Drug Administration (FDA) has cleared the Investigational New Drug (IND) application for PTD802, the Company's lead therapeutic candidate.

From Pheno Therapeutics 22 Jun 2026

Neurodegeneration News and Research

Further Reading

Investigational drug ameliorates neuronal DNA damage and inflammation in Alzheimer's model

New review shows why antidepressants often fail in Alzheimer’s and Parkinson’s depression

Study offers insight into how long-term inflammation may contribute to cognitive decline

Study identifies promising drug target to prevent neurodegenerative conditions

Study provides new insights into biological processes linked to Huntington’s disease

BCG vaccine may remodel the human brain's immune environment

Alzheimer’s disease biomarkers predict rapid cognitive decline in very old adults

Blood biomarker may predict Alzheimer's progression differently in men

Niigata University study updates Alzheimer's risk for APOE-e4 homozygotes

Blood metabolism maps how lifestyle tracks function in cognitive aging

Longer hormone exposure linked to healthier brain aging in women

Iron overload gradually increases neurons' vulnerability to neurodegeneration

Peacemaker immune cells offer new hope for restoring immune tolerance

Discovery of karyoptosis opens new therapeutic targets for Alzheimer's and frontotemporal dementia

High-dose DHA reaches the brain but fails to protect memory

Researchers identify molecular cause of age-related cognitive decline

Pheno Therapeutics granted FDA IND clearance for lead multiple sclerosis therapeutic candidate PTD802

AI discovers hidden antibiotic candidates inside disease-causing prions

Indiana University researchers investigate immune cell aging in Parkinson's disease

Key Alzheimer's protein actively protects neurons from nuclear damage

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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