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Understanding the genetic basis of hereditary diffuse gastric cancer

Gastric cancer, a significant global health burden, claims over 7% of cancer-related deaths annually. Although only 1-3% of cases have a genetic basis, understanding these genetic drivers is crucial for developing preventative strategies.

26 Dec 2023

Shedding new light on the hidden organization of the cytoplasm

Back in 2018, the lab of Christine Mayr, MD, PhD, at Memorial Sloan Kettering Cancer Center (MSK) introduced the world to a key cellular component that had been hiding in plain sight.

21 Dec 2023

D-alanine linked to gluconeogenesis in the kidney and circadian clock

Only recently was it discovered that amino acids, the building blocks of proteins, exist in two different forms: L- and D-forms.

21 Dec 2023

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

19 Dec 2023

Transgenic carrots producing nisin protein show promise as natural food preservatives

Study explores the production of nisin protein in transgenic carrots, demonstrating its potential as a natural preservative effective against bacterial pathogens in food and juices.

18 Dec 2023

Single-cell RNA sequencing generates comprehensive atlas of zebrafish development

Researchers at the National Institutes of Health have published an atlas of zebrafish development, detailing the gene expression programs that are activated within nearly every cell type during the first five days of development, a period in which embryos mature from a single cell into distinct cell types.

18 Dec 2023

Study points to the possibility of using cholesterol-lowering drugs to treat aggressive colorectal tumors

Hard-to-detect colorectal pre-cancerous lesions known as serrated polyps, and the aggressive tumors that develop from them, depend heavily on the ramped-up production of cholesterol, according to a preclinical study from researchers at Weill Cornell Medicine.

18 Dec 2023

Wnt signaling holds promise for tailored immunotherapy in microsatellite-instable colorectal cancer

Colorectal cancer presents with varying clinical characteristics due to tumor heterogeneity. Microsatellite instability (MSI), present in 10%-15% of CRC cases, indicates a different clinical trajectory than microsatellite stable (MSS) patients.

15 Dec 2023

Alzheimer's may worsen COVID-19 outcomes via olfactory mucosa changes

A new study identifies alterations in the transcriptomic signatures in human olfactory mucosal cells of individuals with Alzheimer's disease following SARS-CoV-2 infection, potentially contributing to exacerbated COVID-19 outcomes.

15 Dec 2023

Intranasal COVID-19 vaccine shows promise in reducing severe symptoms

Study evaluates the single-dose intranasal spray vaccine dNS1-RBD, finding it effective against symptomatic COVID-19, particularly in reducing severe symptoms and respiratory issues.

15 Dec 2023

Study finds key gene deletion shields mice from diet-induced obesity and liver disease

Study in the International Journal of Obesity reveals that BMAL1 deletion in mice protects against obesity and non-alcoholic fatty liver disease caused by a high-fat diet, highlighting its potential as a therapeutic target.

13 Dec 2023

Targeting cholesterol metabolism for the treatment of serrated colorectal neoplasms

13 Dec 2023

Organoid study opens new avenues in pulmonary neuroendocrine cancer therapy

Researchers performed a molecular analysis of neuroendocrine neoplasm (NEN) patient-derived tumor organoids (PDTOs) and their parental neoplasms.

13 Dec 2023

MIT scientists develop nanoparticles to reduce inflammation in the brain

Some Covid-19 vaccines safely and effectively used lipid nanoparticles (LNPs) to deliver messenger RNA to cells. A new MIT study shows that different nanoparticles could be used for a potential Alzheimer's disease (AD) therapy.

11 Dec 2023

Study provides a better understanding of how the brain responds to injuries

A new study published in Proceedings of the National Academy of Sciences Nexus provides a better understanding of how the brain responds to injuries.

11 Dec 2023

Breakthrough in pancreatic cancer treatment: Inhibiting specific enzymes slows tumor progression

Study demonstrates that inhibiting stromal class I histone deacetylases (HDACs) can effectively slow down pancreatic cancer progression, shedding light on a new therapeutic approach targeting the tumor microenvironment.

10 Dec 2023

Study sheds light on the molecular workings at play when oxygen exceeds normal levels

It only takes holding your breath for slightly too long to understand that too little oxygen is bad for you. But can you also have too much? Indeed, breathing air with a higher oxygen level than your body needs can cause health problems or even death.

8 Dec 2023

Transcription News and Research

Understanding the genetic basis of hereditary diffuse gastric cancer

Shedding new light on the hidden organization of the cytoplasm

D-alanine linked to gluconeogenesis in the kidney and circadian clock

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Transgenic carrots producing nisin protein show promise as natural food preservatives

Single-cell RNA sequencing generates comprehensive atlas of zebrafish development

Study points to the possibility of using cholesterol-lowering drugs to treat aggressive colorectal tumors

Wnt signaling holds promise for tailored immunotherapy in microsatellite-instable colorectal cancer

Alzheimer's may worsen COVID-19 outcomes via olfactory mucosa changes

Intranasal COVID-19 vaccine shows promise in reducing severe symptoms

Study finds key gene deletion shields mice from diet-induced obesity and liver disease

Targeting cholesterol metabolism for the treatment of serrated colorectal neoplasms

Organoid study opens new avenues in pulmonary neuroendocrine cancer therapy

MIT scientists develop nanoparticles to reduce inflammation in the brain

Study provides a better understanding of how the brain responds to injuries

Breakthrough in pancreatic cancer treatment: Inhibiting specific enzymes slows tumor progression

Study sheds light on the molecular workings at play when oxygen exceeds normal levels

A step forward in vaccine technology: Exploring the effects of N1-methylpseudouridine in mRNA translation

From LED screens to genes: The effects of blue light on aging and m6A methylation in fruit flies

New genetic links to coronary artery calcification uncovered, offering treatment insights

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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