Transcription News and Research

RSS

Transcription factors may drive development of different colorectal cancer subtypes

New research in colorectal cancers directed by investigators at the Johns Hopkins Kimmel Cancer Center suggests that expression of transcription factors — proteins that help turn specific genes on or off by binding to nearby DNA — may play a central role in the degree of DNA methylation across the genome, contributing to the development of different subtypes of these cancers.

27 Jul 2023

Core promoter variation may drive development of triple-negative breast cancer

TNBC is a particularly aggressive subtype of breast cancer, characterized by the absence of three key receptors: estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).

26 Jul 2023

Can epigenetic changes explain the strong link between age and cancer?

Researchers reported the link between aging, cancer, and epigenomic changes.

26 Jul 2023

Cervical fibroblasts in cervical insufficiency patients show impaired responses to progesterone

The study described in Scientific Reports highlights an impaired response to the hormone progesterone (P4) in cervical fibroblasts from patients with refractory cervical insufficiency (CI).

26 Jul 2023

Tumor-derived GDF-15 suppresses immunotherapy response

Researchers evaluate the impact of tumor-derived GDF-15 on responses to anti-PD-1 immunotherapy.

26 Jul 2023

New technique improves bone regeneration in rats

Although bones have the ability to regenerate and repair themselves, they are generally unable to do so when the injury is larger than a small break or chip.

25 Jul 2023

Targeting chronic endometritis: study reveals potential diagnostic markers

Researchers investigated the gene expression signatures and immune cell involvement in chronic endometritis (CE) for potential diagnostic markers.

25 Jul 2023

Unlocking the secrets of asymptomatic COVID-19 infections: HLA-B*15:01 connection revealed

Researchers describe the findings of the COVID-19 Citizen Science Study.

25 Jul 2023

Lactate plays a critical role in helping neural stem cells develop into specialized neurons

Scientists at Tohoku University have discovered the critical role that lactate plays in helping neural stem cells develop into specialized neurons, a process dubbed neuronal differentiation.

24 Jul 2023

Community COVID-19 disease is associated with increased risks of post-viral-illness, fatigue, embolism, and respiratory conditions

Researchers determined the magnitude of changes in healthcare utilization attributable to severe acute respiratory syndrome coronavirus 2.

24 Jul 2023

Breakthrough stress sensor discovery reveals new mechanism of antimicrobial resistance

Researchers from the Antimicrobial Resistance (AMR) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with Singapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University Singapore (NTU Singapore) and Massachusetts Institute of Technology (MIT), have discovered a new stress signaling system that enables bacteria cells to adapt and protect themselves against the immune system and certain antibiotics.

24 Jul 2023

Researchers uncover novel targets for treatment of schistosomiasis

The worms that cause schistosomiasis (Schistosoma mansoni) are unusual in several ways, especially the fact that male and female adults must stay paired together throughout their lives for reproduction to be successful.

21 Jul 2023

Six new Damon Runyon Clinical Investigators announced for 2023

The Damon Runyon Cancer Research Foundation has named six new Damon Runyon Clinical Investigators.

20 Jul 2023

New brain-penetrant agonist shows promise in protecting dopamine neurons for Parkinson's disease treatment

Researchers reported on Nurr1 as a promising therapeutic target for managing Parkinson's disease (PD).

20 Jul 2023

Understanding the mechanisms behind rising antifungal drug resistance

In a recent study, researchers addressed the issue of the rise of antifungal drugs-resistant infections and the advent of multidrug-resistant fungal pathogens.

19 Jul 2023

Study identifies potential immune biomarker for pulmonary tuberculosis: a step towards early detection

Researchers have identified a potential immune biomarker associated with pulmonary TB in active patients compared to controls.

19 Jul 2023

Eternal youth? Chemical cocktails prove effective in cell age reversal

Researchers identified chemical drug combinations that could reverse cellular aging.

19 Jul 2023

Genes that influence pain perception linked to alcohol use disorders

An estimated 16 million people in the United States have alcohol use disorders (AUDs), according to the National Institutes on Alcohol Abuse and Alcoholism (NIAAA).

17 Jul 2023

Unveiling the key defender: PLSCR1 identified as a potent anti-SARS-CoV-2 factor in COVID-19 immunity

Researchers identified the anti-SARS-CoV-2 function of phospholipid scramblase 1 (PLSCR1).

14 Jul 2023

Study uncovers pathogenic variants in the chromatin modifier EZH1 as the cause of neurodevelopmental disorders

Study identified pathogenic variants in the EZH1 as a cause of neurodevelopmental disorders.

14 Jul 2023

Transcription News and Research

Transcription factors may drive development of different colorectal cancer subtypes

Core promoter variation may drive development of triple-negative breast cancer

Can epigenetic changes explain the strong link between age and cancer?

Cervical fibroblasts in cervical insufficiency patients show impaired responses to progesterone

Tumor-derived GDF-15 suppresses immunotherapy response

New technique improves bone regeneration in rats

Targeting chronic endometritis: study reveals potential diagnostic markers

Unlocking the secrets of asymptomatic COVID-19 infections: HLA-B*15:01 connection revealed

Lactate plays a critical role in helping neural stem cells develop into specialized neurons

Community COVID-19 disease is associated with increased risks of post-viral-illness, fatigue, embolism, and respiratory conditions

Breakthrough stress sensor discovery reveals new mechanism of antimicrobial resistance

Researchers uncover novel targets for treatment of schistosomiasis

Six new Damon Runyon Clinical Investigators announced for 2023

New brain-penetrant agonist shows promise in protecting dopamine neurons for Parkinson's disease treatment

Understanding the mechanisms behind rising antifungal drug resistance

Study identifies potential immune biomarker for pulmonary tuberculosis: a step towards early detection

Eternal youth? Chemical cocktails prove effective in cell age reversal

Genes that influence pain perception linked to alcohol use disorders

Unveiling the key defender: PLSCR1 identified as a potent anti-SARS-CoV-2 factor in COVID-19 immunity

Study uncovers pathogenic variants in the chromatin modifier EZH1 as the cause of neurodevelopmental disorders

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Latest News