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AI tool promises to accelerate the development of gene therapies on a large scale

An artificial intelligence (AI) program may enable the first simple production of customizable proteins called zinc fingers to treat diseases by turning genes on and off.

26 Jan 2023

Study reveals why hypoglycemic episodes worsen diabetic retinopathy

People with diabetes who experience periods of low blood sugar — a common occurrence in those new to blood sugar management — are more likely to have worsening diabetic eye disease.

26 Jan 2023

Prenatal MRI helps visualize SARS-CoV-2 infection-induced abnormalities in the placenta and fetuses

Researchers performed a prospective case-control study on pregnant women with confirmed coronavirus disease 2019 (COVID-19).

26 Jan 2023

Scientists use next-generation protein degradation technology to study CTCF's role in transcription

CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children's Research Hospital used a next-generation protein degradation technology to study CTCF.

26 Jan 2023

Updated bivalent mRNA booster protects against circulating SARS-CoV-2 variants

Researchers discuss the efficacy of the bivalent COVID-19 vaccine against symptomatic infection with SARS-CoV-2 variants.

25 Jan 2023

F-box gene mediates dietary restriction effects on extending the health span of C. elegans

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 1, entitled, "The innate immune signaling component FBXC-58 mediates dietary restriction effects on healthy aging in Caenorhabditis elegans."

25 Jan 2023

Scientists demonstrate how microbiome and feeding patterns impact circadian rhythms in the gut

A study published in the journal PNAS reveals that the gut microbiome stabilizes the synchronization between gut and brain circadian rhythms.

24 Jan 2023

Researchers review the association between endogenous retrovirus reactivation and aging

Researchers explored the role of endogenous retrovirus (ERV) reactivation in the aging process.

24 Jan 2023

Review on lateral flow test use spearheaded by SARS-CoV-2 pandemic

Researchers assessed the changing landscape of lateral flow tests (LFTs), and the development of next-generation LFTs based on lessons learnt from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

23 Jan 2023

Researchers evaluate retrospectively obtained health-related quality-of-life data from COVID-19 patients

Researchers evaluated retrospective EQ-5D-5L data collection among COVID-19 patients.

23 Jan 2023

Study suggests Alzheimer’s disease diagnosis is associated with higher levels of soluble ACE2 in the human brain

Researchers investigated ACE2 (angiotensin-converting enzyme 2) levels among individuals with AD (Alzheimer’s disease).

23 Jan 2023

Genetic disorder that causes immunodeficiency and susceptibility to opportunistic infections discovered

An international consortium co-led by Vanderbilt University Medical Center immunogeneticist Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including a life-threatening fungal pneumonia.

23 Jan 2023

Study reveals how neural networks play a key role in the regulation of circadian rhythms

Circadian rhythms are inherent cycles of approximately 24 hours that regulate various biological processes, such as sleep and wakefulness.

19 Jan 2023

Several genes and individual genetic variations associated with atrial fibrillation discovered

In the largest genetic study of heart arrhythmia to date, researchers led by Kazuo Miyazawa and Kaoru Ito at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan report the discovery of several genes and individual genetic variations that are associated with atrial fibrillation.

19 Jan 2023

Partial genetic reprogramming might extend lifespan and reverse aging in old mice

Researchers performed age-reversing experiments, in vivo and in vitro, in progeroid mice using gene therapy.

19 Jan 2023

Research explores the utility of epigenetically predicted BMI

DNA methylation is an accurate predictor of current BMI and a poor predictor of future BMI.

18 Jan 2023

Epitope mapping reveals the humoral responses against the main SARS-CoV-2 structural proteins in infected patients from Africa

Researchers performed immunoglobulin (Ig)M and IgG epitope mapping against 487 SARS-CoV-2 peptides.

18 Jan 2023

The diverse mechanisms by which galectins can regulate adaptive and innate immune responses

Researchers explored ways galectins can impact immunity and discussed the opportunities and challenges in the field.

18 Jan 2023

Combination of multiple maps uncovers new genetic risk factor for AMD

Combining a map of gene regulatory sites with disease-associated loci has uncovered a new genetic risk factor of adult-onset macular degeneration (AMD), according to a new study publishing January 17th in the open access journal PLOS Biology by Ran Elkon and Ruth Ashery-Padan of Tel Aviv University, Israel, and colleagues.

18 Jan 2023

Exploring bioinformatics approach for evaluating binding affinities of probable COVID-19 therapeutic decoys

Researchers developed a computational workflow based on molecular dynamic (MD) simulations and artificial neural network (ANN) to assess the SARS-CoV-2 spike (S) protein receptor-binding domain (RBD)-human angiotensin-converting enzyme 2 (hACE2) binding affinities of SARS-CoV-2 variants.

17 Jan 2023

Transcription News and Research

AI tool promises to accelerate the development of gene therapies on a large scale

Study reveals why hypoglycemic episodes worsen diabetic retinopathy

Prenatal MRI helps visualize SARS-CoV-2 infection-induced abnormalities in the placenta and fetuses

Scientists use next-generation protein degradation technology to study CTCF's role in transcription

Updated bivalent mRNA booster protects against circulating SARS-CoV-2 variants

F-box gene mediates dietary restriction effects on extending the health span of C. elegans

Scientists demonstrate how microbiome and feeding patterns impact circadian rhythms in the gut

Researchers review the association between endogenous retrovirus reactivation and aging

Review on lateral flow test use spearheaded by SARS-CoV-2 pandemic

Researchers evaluate retrospectively obtained health-related quality-of-life data from COVID-19 patients

Study suggests Alzheimer’s disease diagnosis is associated with higher levels of soluble ACE2 in the human brain

Genetic disorder that causes immunodeficiency and susceptibility to opportunistic infections discovered

Study reveals how neural networks play a key role in the regulation of circadian rhythms

Several genes and individual genetic variations associated with atrial fibrillation discovered

Partial genetic reprogramming might extend lifespan and reverse aging in old mice

Research explores the utility of epigenetically predicted BMI

Epitope mapping reveals the humoral responses against the main SARS-CoV-2 structural proteins in infected patients from Africa

The diverse mechanisms by which galectins can regulate adaptive and innate immune responses

Combination of multiple maps uncovers new genetic risk factor for AMD

Exploring bioinformatics approach for evaluating binding affinities of probable COVID-19 therapeutic decoys

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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