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Transcription factors may drive development of different colorectal cancer subtypes

New research in colorectal cancers directed by investigators at the Johns Hopkins Kimmel Cancer Center suggests that expression of transcription factors — proteins that help turn specific genes on or off by binding to nearby DNA — may play a central role in the degree of DNA methylation across the genome, contributing to the development of different subtypes of these cancers.

27 Jul 2023

Study highlights need for integration of policy, behavior change, and risk communication in pandemic response

Researchers measured the association between reproduction number, a weekly measure of real-time severe acute respiratory syndrome coronavirus 2.

27 Jul 2023

How MGI boosts agrigenomics and food sustainability with sequencing technology: an Australian case study

In the wake of the recent UN Food Systems +2 Stocktaking Moment in Rome, the spotlight on global food security has never been more critical. Addressing the challenges of a burgeoning population and changing climate requires innovative solutions, and one area showing remarkable promise is agrigenomics.

From MGI 27 Jul 2023

How do De novo sequencing, QTL mapping, WGS, and lcWGS empower breakthroughs in agrigenomics

Sequencing technology is playing an increasingly important role in agriculture, including crops, livestock and poultry, aquatic organisms, and more.

From MGI 27 Jul 2023

Two infusions of IL-15-expressing CAR NK Cells boost survival in lymphoma mouse models

A new study led by researchers at The University of Texas MD Anderson Cancer Center discovered loss of metabolic fitness in chimeric antigen receptor (CAR) natural killer (NK) cells is a critical mechanism of resistance, with infused cells gradually losing the ability to compete with tumor cells for nutrients, leading to tumor relapse.

26 Jul 2023

Study identifies specific genetic variants that affect the skeletal form and ties a major evolutionary facet of human anatomical change to pathogenesis

Researchers evaluate imaging information and characterize skeletal proportions to assess the genetic root of these traits and their connections to each other.

26 Jul 2023

Designing vaccines to induce a stronger immune response to infecting pathogens

A new paper in Biology Methods & Protocols, published by Oxford University Press, shows it may be possible to design vaccines that will induce a stronger immune response to infecting pathogens, such as the virus causing COVID-19.

25 Jul 2023

$3 million grant to study how sleep and circadian rhythm affect chronic pain

Can poor sleep and circadian rhythm make chronic pain conditions worse? Edson College Assistant Professor Chung Jung Mun plans to find out through an innovative longitudinal study.

24 Jul 2023

Scripps Research scientists develop AI tool to track the detailed evolution of viral pandemics

Scripps Research scientists have developed a machine-learning system - a type of artificial intelligence (AI) application - that can track the detailed evolution of epidemic viruses and predict the emergence of viral variants with important new properties.

21 Jul 2023

AI-powered study pinpoints genes that shape bones

Using artificial intelligence to analyze tens of thousands of X-ray images and genetic sequences, researchers from The University of Texas at Austin and New York Genome Center have been able to pinpoint the genes that shape our skeletons, from the width of our shoulders to the length of our legs.

20 Jul 2023

Immune systems develop specific genes to fight against common bacteria, study finds

Immune systems develop specific genes to combat common bacteria such as those found in food, new research shows.

20 Jul 2023

Research illuminates the genetic basis of human skeletal proportions

Combining data from full-body x-ray images and associated genomic data from more than 30,000 UK Biobank participants, researchers have helped illuminate the genetic basis of human skeletal proportions.

20 Jul 2023

Researchers discover new way to target bacterial cell wall

The bacterial cell wall must be constantly remodeled in order to grow and divide. This involves the close coordination of lytic enzymes and peptidoglycan synthesis.

20 Jul 2023

Finger prick blood sample can detect Alzheimer's biomarkers

Advancements in technology and practice reported for the first time at AAIC 2023 demonstrate the simplicity, transportability and diagnostic value of blood-based biomarkers for Alzheimer's, including the future potential for at-home testing by a patient or a family member.

19 Jul 2023

Understanding the mechanisms behind rising antifungal drug resistance

In a recent study, researchers addressed the issue of the rise of antifungal drugs-resistant infections and the advent of multidrug-resistant fungal pathogens.

19 Jul 2023

Mobile app uses AI to detect eye diseases

Two students on the Master's Degree in Bioinformatics and Biostatistics at the Universitat Oberta de Catalunya (UOC) have developed a mobile app capable of detecting in a matter of seconds whether someone is suffering from glaucoma, diabetic retinopathy or cataracts, three of the world's most common causes of vision loss and blindness.

18 Jul 2023

Meta-analysis confirms 17 key metabolites as strong predictors of gout

Researchers summarized the use of metabolomics to detect metabolites in gout patients.

18 Jul 2023

Normothermic machine preservation shows promise in liver transplantation

A groundbreaking clinical trial comparing conventional low temperature storage of transplant donor livers with storage at physiological body temperature has revealed promising results for the evolution of liver transplantation.

17 Jul 2023

Omicron subvariant BA.5 can cause more severe disease

Omicron-derived virus variants are currently responsible for most SARS-CoV-2 infections worldwide. Compared to earlier virus variants, Omicron rarely causes severe disease.

17 Jul 2023

Primate brain cell atlas provides molecular and cellular basis for neural circuit research

A team of nearly 100 scientists recently mapped the cell-type taxonomy in the macaque cortex and revealed the relationship between cell-type composition and various primate brain regions by using the self-developed spatial transcriptome sequencing technology Stereo-seq and snRNA-seq technology, which provides a molecular and cellular basis for further investigation into neural circuits.

14 Jul 2023

Evolution News and Research

Transcription factors may drive development of different colorectal cancer subtypes

Study highlights need for integration of policy, behavior change, and risk communication in pandemic response

How MGI boosts agrigenomics and food sustainability with sequencing technology: an Australian case study

How do De novo sequencing, QTL mapping, WGS, and lcWGS empower breakthroughs in agrigenomics

Two infusions of IL-15-expressing CAR NK Cells boost survival in lymphoma mouse models

Study identifies specific genetic variants that affect the skeletal form and ties a major evolutionary facet of human anatomical change to pathogenesis

Designing vaccines to induce a stronger immune response to infecting pathogens

$3 million grant to study how sleep and circadian rhythm affect chronic pain

Scripps Research scientists develop AI tool to track the detailed evolution of viral pandemics

AI-powered study pinpoints genes that shape bones

Immune systems develop specific genes to fight against common bacteria, study finds

Research illuminates the genetic basis of human skeletal proportions

Researchers discover new way to target bacterial cell wall

Finger prick blood sample can detect Alzheimer's biomarkers

Understanding the mechanisms behind rising antifungal drug resistance

Mobile app uses AI to detect eye diseases

Meta-analysis confirms 17 key metabolites as strong predictors of gout

Normothermic machine preservation shows promise in liver transplantation

Omicron subvariant BA.5 can cause more severe disease

Primate brain cell atlas provides molecular and cellular basis for neural circuit research

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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