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Scientists identify key cell signaling pathway that drives muscle loss

Researchers at the University of Nebraska Medical Center have identified a key cell signaling pathway that drives the devastating muscle loss, or cachexia, suffered by many cancer patients.

22 May 2020

New review analyzes evidence and strategies to manage the SARS-CoV-2 virus

How should orthopaedic surgeons respond to the COVID-19 pandemic? A review in The Journal of Bone & Joint Surgery analyzes evidence and strategies for managing the novel SARS-CoV-2 virus - including critical lessons from past pandemics.

22 May 2020

New clinical trial to test treatment that targets overactive immune response to COVID-19

For some COVID-19 patients, the body's immune response may be as destructive as the virus that causes the disease.

22 May 2020

IL-6 blocker use in severe COVID-19 increases risk of secondary infections

With many hundreds of thousands of deaths due to the current COVID-19 pandemic, there is a rush to find an effective vaccine or drug against the virus. A new study on the preprint server medRxiv* in May 2020 shows that the use of some biologically plausible drugs may be counterproductive, and care should be taken when trying out unproven therapies.

22 May 2020

Study evaluates the effectiveness of interferon beta 1b in COVID-19 pneumonia

As the world struggles to overcome the current COVID-19 pandemic with non-pharmacological interventions, in the absence of an effective drug or vaccine, existing immunomodulators are being repurposed. A new study published on the preprint server medRxiv* in May 2020 shows no clinical benefit to the use of one such drug, called interferon beta 1b (IFN beta1b).

22 May 2020

Preparing to meet SARS-CoV-2 head-on with a panel of neutralizing antibodies

A new study published on the preprint server bioRxiv in May 2020 describes a panel of neutralizing antibodies that bind to multiple attachment sites on the spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 disease pandemic.

22 May 2020

RAAS inhibitors are safe to use in COVID-19 patients, study shows

The coronavirus disease (COVID-19) is a novel illness that has spread across the globe in just five months. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the viral infection binds to the angiotensin-converting enzyme 2 (ACE2) to enter and invade cells.

21 May 2020

ELISA and CLIA antibody tests for SARS-CoV-2 perform best in terms of sensitivity

Testing for those who have developed antibodies against the coronavirus can help tackle the ongoing COVID-19 pandemic. Now, a new study has identified all the antibody tests available for the coronavirus disease (COVID-19) to determine which performs better and is more accurate.

21 May 2020

Excessive blood clotting and stroke in COVID-19 patients

The coronavirus disease COVID-19 is causing excessive blood clotting and stroke in young and healthy people, a new study has found.

21 May 2020

Study presents early data on SARS‐CoV ‐2 testing, outcomes at Australian children’s hospital

In the first 30 days since seeing their first patient, the number of children testing positive to COVID-19 at an Australian tertiary pediatric hospital has been low and none who contracted the virus required in-hospital treatment, according to a new study.

21 May 2020

COVID-19 may damage the central nervous system

Researchers at University Hospital Düsseldorf, Germany, have provided important insights into the potential impact that coronavirus disease 2019 (COVID-19) could have on the central nervous system.

21 May 2020

Mutations in SARS-CoV-2 may explain its dominance and spread

Researchers at Dokuz Eylül University, Turkey, have identified mutations in the genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may have contributed to its dominance in Europe and elsewhere.

21 May 2020

Study shows selenium-containing compounds inhibit SARS-CoV-2 replication and assembly

A recent paper by researchers from the Netherlands and Poland provides evidence that modified ebselen derivatives may serve as highly promising prospective drugs against coronavirus disease 2019 (COVID-19). The manuscript is freely available on the bioRxiv* preprint server.

21 May 2020

Computational immunology paves the way for SARS-CoV-2 peptide cocktail vaccine candidate

By employing an immunoinformatics approach, a new study available on the preprint server bioRxiv* shows how the combination of peptides designed from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid phosphoprotein and spike glycoprotein may trigger an improved immunological response with respectable safety profile, informing, in turn, further vaccine development.

21 May 2020

COVID-19 in farmed Mink in the Netherlands

A new study published on the preprint server bioRxiv in May 2020 reports the development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in farmed mink in two locations in the Netherlands.

21 May 2020

Does abdominal fat affect COVID-19 outcomes?

As the COVID-19 pandemic seems to be slowing down in some parts of the world slightly but accelerating in others, scientists are investigating the role played by a host of factors that might impact the final outcome. A new study published on the preprint server medRxiv* in May 2020 examines the role of abdominal fat (visceral obesity, VO) in severe COVID-19.

21 May 2020

Saliva testing allows quick, accurate and non-invasive SARS-CoV-2 detection

Saliva is one of the ways people can transmit the novel coronavirus to others, but it may also help combat coronavirus disease (COVID-19). Scientists are now looking into using saliva to test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for COVID-19 disease.

20 May 2020

Lifesaving innovation for COVID-19 will increase the already existing racial inequalities

As is the case with most fatal diseases, coronavirus disease (COVID-19) is already taking a disproportionate toll on black Americans and other disadvantaged minorities.

20 May 2020

Universal testing of asymptomatic pregnant women may not be necessary, study suggests

A study conducted by investigators at Cedars-Sinai suggests that universal testing of asymptomatic pregnant women in labor may not be necessary at every hospital.

20 May 2020

MIT researchers describe new methods for accelerating drug approvals during pandemics

In response to the COVID-19 pandemic, researchers from the Massachusetts Institute of Technology have published a pair of studies in a COVID-19 special issue of the Harvard Data Science Review, freely available via open access, describing new methods for accelerating drug approvals during pandemics and for providing more accurate measures of the probabilities of success for clinical trials of vaccines and other anti-infective therapies.

20 May 2020

Syndrome News and Research

Scientists identify key cell signaling pathway that drives muscle loss

New review analyzes evidence and strategies to manage the SARS-CoV-2 virus

New clinical trial to test treatment that targets overactive immune response to COVID-19

IL-6 blocker use in severe COVID-19 increases risk of secondary infections

Study evaluates the effectiveness of interferon beta 1b in COVID-19 pneumonia

Preparing to meet SARS-CoV-2 head-on with a panel of neutralizing antibodies

RAAS inhibitors are safe to use in COVID-19 patients, study shows

ELISA and CLIA antibody tests for SARS-CoV-2 perform best in terms of sensitivity

Excessive blood clotting and stroke in COVID-19 patients

Study presents early data on SARS‐CoV ‐2 testing, outcomes at Australian children’s hospital

COVID-19 may damage the central nervous system

Mutations in SARS-CoV-2 may explain its dominance and spread

Study shows selenium-containing compounds inhibit SARS-CoV-2 replication and assembly

Computational immunology paves the way for SARS-CoV-2 peptide cocktail vaccine candidate

COVID-19 in farmed Mink in the Netherlands

Does abdominal fat affect COVID-19 outcomes?

Saliva testing allows quick, accurate and non-invasive SARS-CoV-2 detection

Lifesaving innovation for COVID-19 will increase the already existing racial inequalities

Universal testing of asymptomatic pregnant women may not be necessary, study suggests

MIT researchers describe new methods for accelerating drug approvals during pandemics

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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