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New insights into biophysical origins of the genome's organization inside the cell nucleus

A team of scientists has uncovered the physical principles - a series of forces and hydrodynamic flows - that help ensure the proper functioning of life's blueprint.

19 Dec 2022

First cell-type specific multiomic study of the HIV brain

Researchers identify cell-type-specific differences in HIV integration sites in the brain.

19 Dec 2022

Modulation of insect immunity to control vector-borne diseases

Discussed the current research on the role of molecular mechanisms in mediating immune priming in insects and regulating vector-borne disease transmission.

19 Dec 2022

Study shows SARS-CoV-2 infection, replication and persistence in human brain tissues

Researchers investigated the cellular tropism, replication competence, persistence and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, and associated histopathological changes in infected tissues.

16 Dec 2022

New mutations near known genes could contribute to the increase in cleft lip and palate risk

Cleft lip and palate are among the most common congenital malformations, which are mainly due to genetic causes.

16 Dec 2022

Changing heart cell programming can reverse the lasting damage caused by heart attacks

Back in 1971, the Bee Gees asked, "How can you mend a broken heart?". Now, researchers from Japan reveal that they may just have found a way to repair cardiac damage in patients suffering from chronic heart attack and heart failure.

16 Dec 2022

Study reports that delaying surgery post-COVID-19 reduces the risk of postoperative cardiovascular issues

Researchers assessed the temporal relationship between COVID-19 diagnosis and surgery time with the risk of occurrence of cardiovascular morbidity events within 30 days of surgery.

16 Dec 2022

Using synthetic gene circuits to better control the timing of immunotherapy

In two separate studies, researchers demonstrate how synthetic biology can be used to tackle a difficult issue in cancer immunotherapy: the way immunotherapy-related approaches focused on short-term killing of tumor cells may fail to eradicate tumors because growth of tumors happens on longer timescales.

16 Dec 2022

mRNA vaccine methodologies: Production, value and spectrometer use

To be decided by the editor

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 16 Dec 2022

Scientists uncover how FoxH1 factor binds to specific points in the genome

Transcription factors are proteins that interact with DNA to regulate the function of some genes. Generally, a single transcription factor binds to several regions in the genome as it orchestrates complex cellular responses, which require the activation or inhibition of several genes.

15 Dec 2022

Extraordinary plasticity of the glucocorticoid receptor revealed

Glucocorticoids —such as cortisone— are among the most widely used anti-inflammatory drugs, and are used to treat asthma, psoriasis, organ transplantation and even COVID-19.

15 Dec 2022

The implications of pulmonary tissue-resident memory T lymphocytes in COVID-19 and other respiratory diseases

Researchers elucidated the mechanisms of long-term T lymphocyte lodgement in tissues other than lymphoid tissues and the reasons for the transient residency of specific subsets of tissue-resident memory T (TRM) lymphocytes.

14 Dec 2022

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Researchers isolated SARS-CoV-2 spike protein-targeted mAbs from convalescent healthcare workers, emphasizing the IGHV1-69 gene, the gene with the greatest structural and allelic variation.

14 Dec 2022

Scientists use single-cell multi-omics data to map disease regulatory circuits

Researchers apply MAGICAL for the identification of modulated host response regulatory circuits in response to Staphylococcus aureus.

12 Dec 2022

Study of 1.1 million children finds no association between SARS-CoV-2 infection and type 1 diabetes risk

Researchers investigate whether the risk of new-onset type 1 diabetes is elevated by SARS-CoV-2 infections among children living in Denmark.

11 Dec 2022

What is the association between farnesoid X receptor inhibition and protection against COVID-19?

Researchers assessed the association between farnesoid X receptor (FXR) inhibition and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

9 Dec 2022

Better understanding of DNA repair mechanism may pave the way for effective cancer treatments

Better understanding of the mechanisms involved in DNA repair may pave the way for developing inhibitors to improve the effectiveness of radiation therapy.

9 Dec 2022

Study reveals how the HOXA5 gene may work to suppress breast cancer formation

Researchers at the Johns Hopkins Kimmel Cancer Center have revealed how the gene HOXA5 may work to suppress formation of breast cancers.

8 Dec 2022

Study looks at the possibility of promoting hair cell regeneration using cell reprograming

About 430 million people around the world experience disabling hearing loss. In the United States, approximately 37.5 million adults report some trouble hearing. Hearing loss can happen when any part of the ear or the nerves that carry information on sounds to the brain do not work in the usual way.

8 Dec 2022

New spatial cell atlas of the developing human lung identifies 144 cell states

The developing human lung has been mapped in unprecedented detail, identifying 144 cell states in the early stages of life, and uncovering new links between developmental cells and lung cancer.

8 Dec 2022

Transcription News and Research

New insights into biophysical origins of the genome's organization inside the cell nucleus

First cell-type specific multiomic study of the HIV brain

Modulation of insect immunity to control vector-borne diseases

Study shows SARS-CoV-2 infection, replication and persistence in human brain tissues

New mutations near known genes could contribute to the increase in cleft lip and palate risk

Changing heart cell programming can reverse the lasting damage caused by heart attacks

Study reports that delaying surgery post-COVID-19 reduces the risk of postoperative cardiovascular issues

Using synthetic gene circuits to better control the timing of immunotherapy

mRNA vaccine methodologies: Production, value and spectrometer use

Scientists uncover how FoxH1 factor binds to specific points in the genome

Extraordinary plasticity of the glucocorticoid receptor revealed

The implications of pulmonary tissue-resident memory T lymphocytes in COVID-19 and other respiratory diseases

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Scientists use single-cell multi-omics data to map disease regulatory circuits

Study of 1.1 million children finds no association between SARS-CoV-2 infection and type 1 diabetes risk

What is the association between farnesoid X receptor inhibition and protection against COVID-19?

Better understanding of DNA repair mechanism may pave the way for effective cancer treatments

Study reveals how the HOXA5 gene may work to suppress breast cancer formation

Study looks at the possibility of promoting hair cell regeneration using cell reprograming

New spatial cell atlas of the developing human lung identifies 144 cell states

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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