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Researchers investigate effects of new steroid treatment on children with ARDS

Acute Respiratory Distress Syndrome (ARDS) affects hundreds of thousands of people each year, many of them children. Those with this life threatening condition have severely injured and wet lungs, and are treated with mechanical ventilation.

9 May 2016

Wolff-Parkinson-White patients continue to have atrial fibrillation risk even after catheter ablation, study finds

Patients with Wolff-Parkinson-White syndrome who receive catheter ablation to cure their abnormal heart rhythms are just as likely as non-ablated patients to develop atrial fibrillation no matter what age they receive ablation, according to a new study.

6 May 2016

Detailed digital models of human organs could bring substantial benefits to clinical trials

Computer simulations of disease processes and detailed digital models of our organs could provide more accurate monitoring and outcome measurements for clinical trials, according to research being presented in Sheffield today.

5 May 2016

Bayer-new phase 3 liver cancer data

Bayer has announced that a Phase III trial evaluating its oncology compound Stivarga® (regorafenib) tablets for the treatment of patients with unresectable hepatocellular carcinoma (HCC) has met its primary endpoint of a statistically significant improvement in overall survival. The study, called RESORCE, evaluated the efficacy and safety of regorafenib in patients with HCC whose disease has progressed after treatment with sorafenib. The safety and tolerability were generally consistent with the known profile of regorafenib. Detailed efficacy and safety analyses from this study are expected to be presented at an upcoming scientific congress.

4 May 2016

Real risk of rebound syndrome following fingolimod cessation for MS

Rebound syndrome following cessation of fingolimod for multiple sclerosis occurs at a clinically relevant rate, shows research, prompting the need for further study on how best to sequence and discontinue such drugs.

4 May 2016

New study links cathepsin S protein to tear secretion in Sjogren's syndrome patients

The autoimmune disorder Sjogren's syndrome is often overlooked or misdiagnosed because the symptoms are similar to other conditions. Its characteristic symptoms are dry eyes and dry mouth, and reduced tear production is used as part of the diagnosis.

4 May 2016

Researchers identify 43 specific genes associated with both autism and cancer

Autism and cancer share more than 40 risk genes, suggesting that common mechanisms underlying the functions of some of these genes could conceivably be leveraged to develop therapies not just for cancer but for autism as well, an extensive assessment by researchers with the UC Davis MIND Institute and Comprehensive Cancer Center has found.

4 May 2016

Researchers explore effects of adolescent obesity on cognitive performance in adulthood

The Franco-Mexican research explores the cognitive performance in adulthood when the subjects have been exposed to an obesogenic environment during adolescence.

30 Apr 2016

Black raspberry intake can lower key measure of arterial stiffness in patients with metabolic syndrome

A new study shows that black raspberry extract can significantly lower a key measure of arterial stiffness-an indicator of cardiovascular disease. Black raspberry intake was also associated with increased levels of circulating endothelial progenitor cells (EPCs), which help repair and regenerate damaged arteries, according to the study published in Journal of Medicinal Food, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Medicinal Food website until May 28, 2016.

29 Apr 2016

More neurological resources needed to manage Zika virus infections

WFN Zika-Info-Service: World Federation of Neurology establishes Work Group on Zika virus to support international efforts - Lack of neurological resources in countries most concerned by the virus.

28 Apr 2016

Novel spoken-language intervention could benefit children, adolescents with developmental disabilities

Sean Sawicki, who has fragile X syndrome, can be hard to understand and doesn't always have the attention span to carry on a sustained conversation. But a novel intervention developed by UC Davis MIND Institute researchers seems to be making a difference.

28 Apr 2016

Diagnosing heart attacks in 1 hour: an interview with Dr Richard Body

Cardiac troponin is a highly sensitive and specific biomarker for myocardial injury but concentrations in the blood rise over several hours after the onset of an acute myocardial infarction.

28 Apr 2016

Experimental cancer drug Nutlin-3 shows promise in cancelling effects of fragile X syndrome

A University of Wisconsin-Madison researcher who studies the most common genetic intellectual disability has used an experimental drug to reverse — in mice — damage from the mutation that causes the syndrome.

28 Apr 2016

Patients with impaired consciousness show uncontrolled communication between resting-state networks

An international research team has investigated interactions in different states of consciousness and has discovered that patients with severely impaired consciousness show a pathological or uncontrolled communication between resting-state networks.

28 Apr 2016

Rapamycin drug could target neural damage linked to Leigh syndrome

Salk Institute scientists showed how an FDA-approved drug boosts the health of brain cells by limiting their energy use. Like removing unnecessary lighting from a financially strapped household to save on electricity bills, the drug--called rapamycin--prolongs the survival of diseased neurons by forcing them to reduce protein production to conserve cellular energy.

27 Apr 2016

New fruit fly model study reveals metabolic pathway that can be targeted to treat FXS patients

Fragile X syndrome (FXS) is the most common genetically inherited cause of intellectual disability in humans. New research shows how the hormone insulin -- usually associated with diabetes -- is involved in the daily activity patterns and cognitive deficits in the fruitfly model of FXS, according to a new study from the Perelman School of Medicine at the University of Pennsylvania published online this month in Molecular Psychiatry in advance of the print issue.

27 Apr 2016

First small molecule targeted therapy holds promise for Usher syndrome

Usher syndrome (USH) is characterized by hearing loss or deafness at birth and progressive vision loss, and is the most common cause of inherited dual sensory deficit. No treatment is currently available to stop or slow the progression of vision or hearing loss in USH3, one of three clinical classifications for USH that are further divided into subtypes and all associated with different genes.

27 Apr 2016

Transforming MR images into body composition measurements: an interview with Olof Leinhard

Today's medical science utilizes relatively simple anthropometric measures that describe the body, such as body mass index (BMI) and waist circumference. All of these measures are approximations of the body with the intention to characterize what's inside reflecting underlying phenomena that underpin the risk for different diseases.

26 Apr 2016

Why don’t MS patients always engage with specialists? An interview with Dr Anita Rose

The recent survey you ask about was conducted by the MS Trust in 2012. It revealed that nearly one fifth of respondents had seen neither an MS specialist nurse (MSSN) nor a neurologist in the past year, and so will not have received the comprehensive annual review recommended by the National Institute for Health and Care Excellence (NICE).

25 Apr 2016

Sleep loss influences cholesterol metabolism, study finds

Lack of sleep has previously been found to impact the activation of the immune system, inflammation, carbohydrate metabolism and the hormones that regulate appetite. Now University of Helsinki researchers have found that sleep loss also influences cholesterol metabolism.

22 Apr 2016

Syndrome News and Research

Researchers investigate effects of new steroid treatment on children with ARDS

Wolff-Parkinson-White patients continue to have atrial fibrillation risk even after catheter ablation, study finds

Detailed digital models of human organs could bring substantial benefits to clinical trials

Bayer-new phase 3 liver cancer data

Real risk of rebound syndrome following fingolimod cessation for MS

New study links cathepsin S protein to tear secretion in Sjogren's syndrome patients

Researchers identify 43 specific genes associated with both autism and cancer

Researchers explore effects of adolescent obesity on cognitive performance in adulthood

Black raspberry intake can lower key measure of arterial stiffness in patients with metabolic syndrome

More neurological resources needed to manage Zika virus infections

Novel spoken-language intervention could benefit children, adolescents with developmental disabilities

Diagnosing heart attacks in 1 hour: an interview with Dr Richard Body

Experimental cancer drug Nutlin-3 shows promise in cancelling effects of fragile X syndrome

Patients with impaired consciousness show uncontrolled communication between resting-state networks

Rapamycin drug could target neural damage linked to Leigh syndrome

New fruit fly model study reveals metabolic pathway that can be targeted to treat FXS patients

First small molecule targeted therapy holds promise for Usher syndrome

Transforming MR images into body composition measurements: an interview with Olof Leinhard

Why don’t MS patients always engage with specialists? An interview with Dr Anita Rose

Sleep loss influences cholesterol metabolism, study finds

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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