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Absence of Shp-2 enzyme near cartilage cells can lead to multiple benign cartilage tumors in mice

Rhode Island Hospital researchers have found that the absence of the Shp-2 enzyme near specialized cartilage cells can lead to the development of multiple benign cartilage tumors in mice, a model that recapitulates the rare human tumor syndrome metachondromatosis.

20 Jul 2013

Boston Scientific initiates OPTIMISE trial to study ONS using Precision System for chronic migraine

Boston Scientific Corporation has launched a clinical trial to determine whether occipital nerve stimulation using the Precision System can safely and effectively treat chronic migraine when used in conjunction with anti-migraine medications.

20 Jul 2013

Keele researchers receive fund to find effectiveness of common treatments for carpal tunnel

Researchers at Keele University, UK, have been awarded funding from Arthritis Research UK to find out more about the effectiveness of common treatments for carpal tunnel syndrome, a painful, common condition affecting trapped nerves in the hand and wrists.

20 Jul 2013

Teduglutide offers relief for patients with short-bowel syndrome

A new drug, teduglutide, offers significant relief for patients with short-bowel syndrome intestinal failure who are reliant on intravenous nutrition, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

19 Jul 2013

FDA grants orphan drug designation to ARMAGEN's AGT-182 for treatment of Hunter syndrome

ARMAGEN announced today that the U.S. Food and Drug Administration has granted orphan drug designation to its lead product AGT-182 for the treatment of mucopolysaccharidosis type II (also known as Hunter syndrome or MPS II).

19 Jul 2013

Bausch + Lomb obtains option to license MIM-D3 for treatment of dry eye syndrome

Bausch + Lomb, the global eye health company, and Mimetogen Pharmaceuticals Inc. today announced that Bausch + Lomb has acquired an option to license an investigational compound currently in Phase 2 development for the treatment of dry eye syndrome, a condition that affects millions of people worldwide.

19 Jul 2013

Safe Life FZC employs NanoSeptic self-cleaning products to combat MERS outbreak

Safe Life FZC, a new breed of healthcare distributors based in United Arab Emirates, is employing the latest technology to combat dangerous outbreaks like the deadly Coronavirus or MERS (Middle East Respiratory Syndrome).

18 Jul 2013

New book examines links between violence against women and mental health

The book, written and supported by international leaders in mental health and women's issues, provides the first comprehensive overview on this crisis, examining the links between violence against women and mental health and the underlying causes, as well as the implications of these findings for mental health policies and programs.

18 Jul 2013

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

Scientists at the University of Massachusetts Medical School are the first to establish that a naturally occurring X chromosome "off switch" can be rerouted to neutralize the extra chromosome responsible for trisomy 21, also known as Down syndrome, a genetic disorder characterized by cognitive impairment.

18 Jul 2013

UCI-led study point to new approach for treating foodborne illnesses

UC Irvine microbiologists have learned how a probiotic bacterium used to treat irritable bowel syndrome can soothe gut bacterial infections caused by Salmonella, paving the way for potential relief from foodborne illnesses that affect millions of people annually.

18 Jul 2013

Long-term cannabis use, dopamine and motivation: an interview with Dr Michael Bloomfield, Department of Medicine at Imperial

We classified ‘long-term’ cannabis use as being regular, at least weekly, cannabis use for over 12 months. This is the period of time that’s used in the DSM-IV psychiatric diagnostic manual to classify substance use disorders. In our study the average duration of at least weekly use was just over four and a half years.

17 Jul 2013

Alize Pharma initiates AZP-531 Phase I clinical trial for treatment of type 2 diabetes

Alize Pharma, a company specialized in the development of drugs for the treatment of metabolic diseases and rare diseases, announces today the launch of the first Phase I clinical trial for AZP-531, its unacylated ghrelin analog, in type 2 diabetes.

16 Jul 2013

Furiex Pharmaceuticals enrolls patient for Phase III clinical trial of eluxadoline for treatment of diarrhea

Furiex Pharmaceuticals, Inc. (NASDAQ: FURX) today announced completion of patient enrollment in the company's two ongoing Phase III clinical trials studying eluxadoline for the treatment of diarrhea-predominant irritable bowel syndrome, or IBS-d. Both studies met their target enrollments and Furiex expects to release top line results in the first quarter of 2014.

16 Jul 2013

Fixed-ratio transfusion protocol in trauma patients is feasible, but wastes blood plasma

The use of a 1:1:1 blood transfusion protocol in patients with severe trauma is feasible in hospitals, although it is associated with higher waste of plasma, according to a randomized trial published in CMAJ (Canadian Medical Association Journal).

16 Jul 2013

'Defanged' HIV used to deliver gene therapy

Researchers are having success using a "defanged" version of HIV to deliver gene therapy to children suffering from genetic diseases, a development that could improve other such care.

15 Jul 2013

First Edition: July 12, 2013

Today's early morning highlights from the major news organizations, including articles on data tracking of doctors and comparing the rollout of the Medicare Part D drug plans to implementation of the federal health law.

12 Jul 2013

Scientists discover chain of molecular mechanisms set in motion by glucocorticoids

These scientists under the leadership of Martin Bilban from the Clinical Institute of Laboratory Medicine at the MedUni Vienna discovered a chain of molecular mechanisms, which is kick-started by the formation of glucocorticoids.

12 Jul 2013

Genome sequencing promises to identify rare mutations that give rise to autism

An international consortium, consisting of Autism Speaks, Duke University School of Medicine, The Hospital for Sick Children of Toronto, BGI and other institutes, has investigated the genetic variants in 32 families with Autism Spectrum Disorder (ASD).

12 Jul 2013

Risk-factor screening of high-risk children may delay or prevent chronic health conditions later in life

Mexican American children are experiencing substantial burdens of obesity, pre-diabetes, and other health problems which historically would have been expected to develop much later in life. The findings of a new study by Texas Biomed scientists in San Antonio argue for early screening and intervention to delay or avoid chronic health problems as these children age.

12 Jul 2013

Researchers develop new cry analyzer to look for clues about baby's health

To parents, a baby's cry is a signal of hunger, pain, or discomfort. But to scientists, subtle acoustic features of a cry, many of them imperceptible to the human ear, can hold important information about a baby's health.

12 Jul 2013

Syndrome News and Research

Absence of Shp-2 enzyme near cartilage cells can lead to multiple benign cartilage tumors in mice

Boston Scientific initiates OPTIMISE trial to study ONS using Precision System for chronic migraine

Keele researchers receive fund to find effectiveness of common treatments for carpal tunnel

Teduglutide offers relief for patients with short-bowel syndrome

FDA grants orphan drug designation to ARMAGEN's AGT-182 for treatment of Hunter syndrome

Bausch + Lomb obtains option to license MIM-D3 for treatment of dry eye syndrome

Safe Life FZC employs NanoSeptic self-cleaning products to combat MERS outbreak

New book examines links between violence against women and mental health

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

UCI-led study point to new approach for treating foodborne illnesses

Long-term cannabis use, dopamine and motivation: an interview with Dr Michael Bloomfield, Department of Medicine at Imperial

Alize Pharma initiates AZP-531 Phase I clinical trial for treatment of type 2 diabetes

Furiex Pharmaceuticals enrolls patient for Phase III clinical trial of eluxadoline for treatment of diarrhea

Fixed-ratio transfusion protocol in trauma patients is feasible, but wastes blood plasma

'Defanged' HIV used to deliver gene therapy

First Edition: July 12, 2013

Scientists discover chain of molecular mechanisms set in motion by glucocorticoids

Genome sequencing promises to identify rare mutations that give rise to autism

Risk-factor screening of high-risk children may delay or prevent chronic health conditions later in life

Researchers develop new cry analyzer to look for clues about baby's health

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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