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Researchers discover key role of RAP1 gene in obesity

The discovery of an unexpected function for a gene that was associated to another process in the organism might be a solution in search of a problem, a clue to unsuspected connections. That is what has happened with RAP1, a gene that protects telomeres- the ends of chromosomes-after researchers from the Spanish National Cancer Research Centre surprisingly discovered its key role in obesity.

21 Jun 2013

New book explores experiences of polio victims alongside medical, scientific landmarks

Thanks to vaccination, polio has been pushed to the brink of extinction - but can we finish the job? This is one of the big questions which a Bristol academic addresses in his new book, published next week.

20 Jun 2013

Research: Fetal exposure to BPA causes inflammation in fat tissues after birth

New research suggests that fetal exposure to the common environmental chemical bisphenol A, or BPA, causes increased inflammation in fat tissues after birth, which can lead to obesity and metabolic syndrome. Results of the animal study were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco.

19 Jun 2013

Risk assessment scoring system may help identify adults at risk of developing type 2 diabetes

Researchers have developed a risk assessment scoring system that they believe may better identify certain adults-- especially African Americans-- at high risk of developing type 2 diabetes, heart disease and stroke than does the current system of diagnosing the metabolic syndrome.

19 Jun 2013

Special type of IVF may increase risk for insulin resistance among children

A special type of in vitro fertilization, or IVF, may increase the risk for insulin resistance among children conceived in this way, according to a new study from Greece. The results will be presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco.

18 Jun 2013

Women with polycystic ovary syndrome lose more weight when they take two drugs

Women with polycystic ovary syndrome, or PCOS, lost significantly more weight when they took two drugs that are traditionally used to treat diabetes, rather than either drug alone, a study from Slovenia demonstrates. The results will be presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco.

18 Jun 2013

kisspeptin hormone effectively induces egg maturation during infertility treatment, shows study

The naturally occurring hormone kisspeptin effectively induces egg maturation during infertility treatment, according to a clinical in vitro fertilization (IVF) study. The results were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco.

18 Jun 2013

New study identifies possible treatment to block deposition of calcium in arterial wall

HGPS is a rare genetic disease that affects one in every 4-8 million births. The disease is caused by a spontaneous mutation in one of the two copies (alleles) of the gene LMNA, which codes for lamin A, a protein important for the integrity and function of the envelope surrounding the cell nucleus. The mutation causes incorrect processing of the messenger RNA for lamin proteins, resulting in the synthesis of an anomalous protein, called progerin.

18 Jun 2013

Drug increases amount of energy burned by fat tissue and promotes weight loss

A drug that mimics the activity of thyroid hormone significantly increases the amount of energy burned by fat tissue and promotes weight loss, an animal study of metabolism finds. The results were presented Sunday at The Endocrine Society's 95th Annual Meeting in San Francisco.

18 Jun 2013

Researchers identify genetic mutation responsible for MDP Syndrome

National Paracycling Champion Tom Staniford has an extremely rare condition which, until now, has puzzled his doctors. He is unable to store fat under his skin - yet has type 2 diabetes - and suffered hearing loss as a child. Now, thanks to advances in genome sequencing, an international research team led by the University of Exeter Medical School has identified Tom's condition and pinpointed the single genetic mutation that causes it.

17 Jun 2013

Weekend reading: Seeking better health outcomes for homeless people; What becomes of the women denied abortions?

Even before President Obama signed the Affordable Care Act into law, Republicans were vowing to repeal it. It's no wonder, because polls showed that the basic elements of the ACA were quite popular, and there was a real danger that it would become more so as people found out that the plan denounced as a "monstrosity" by the National Republican Senatorial Committee would not trample on their liberties so much as help protect their health.

15 Jun 2013

Celgene reports results from placebo-controlled phase II trial in patients with Behçet's disease

Celgene International Sàrl, a subsidiary of Celgene Corporation today presented results from a randomized, placebo-controlled phase II trial in patients with Behçet's disease at EULAR, the European Congress of Rheumatology annual meeting in Madrid.

14 Jun 2013

CSHL scientists solve the mystery of why some infants born with grave syndrome

By identifying a protein that acts as a genetic modifier, scientists at Cold Spring Harbor Laboratory have solved the mystery of why some infants are born with a grave syndrome consisting of cleft palate and major deformities of the skin and limbs, while other infants bearing the same predisposing genetic mutation bear little or no sign of the illness, called EEC.

14 Jun 2013

Novel antibody biomarkers could significantly improve diagnosis in RA, study shows

Data presented at EULAR 2013, the Annual Congress of the European League Against Rheumatism, show that novel antibody biomarkers could significantly improve diagnosis in rheumatoid arthritis.

14 Jun 2013

Ambry Genetics introduces BRCA1 and BRCA2 analysis

Ambry Genetics announced today the launch of BRCA1 and BRCA2 analysis as part of their comprehensive cancer-testing menu. Two genes will be offered as a stand alone test comprising of full gene sequencing and deletion/duplication analyses in addition to being incorporated as part of multiple hereditary cancer panels that test cancer susceptibility genes using next-generation sequencing technology.

14 Jun 2013

NACC recommendations address established pain therapies and preview potential future advances

Recommendations of the Neuromodulation Appropriateness Consensus Committee (NACC), announced at the 11th World Congress of the International Neuromodulation Society (INS), address established therapies and preview emerging and potential future advances.

13 Jun 2013

Omeros gets regulatory clearance to begin Phase 1 clinical trial of OMS721

Omeros Corporation today announced that it has obtained regulatory clearance to start the Phase 1 clinical trial evaluating OMS721, the Company's lead human monoclonal antibody from its mannan-binding lectin-associated serine protease-2 (MASP-2) program.

13 Jun 2013

Constella® (linaclotide), for the symptomatic treatment of Irritable Bowel Syndrome with Constipation (IBS-C), is now available in Germany, UK and Nordic countries

Almirall, S.A. (ALM:MC) and Ironwood Pharmaceuticals, Inc. (NASDAQ: IRWD) announced the launch of Constella® (linaclotide 290mcg capsules once daily), the first approved prescription therapy in a new class of treatments for adults suffering from moderate to severe IBS-C,(1) in Europe. Constella® is now available in Germany, the UK and Nordic countries and is expected to be launched in several other European countries in 2013.

13 Jun 2013

Viewpoints: Administration 'finally' comes around on Plan B; 'Legal loophole' creates another compounded drug scare

Reluctantly yielding to a federal-court decision, the Obama administration announced on Monday that it will take steps to allow a version of the so-called morning-after pill, known as Plan B One-Step, to be sold over the counter to girls and women of all ages. They will not need a prescription, nor will they be required to show any identification to obtain the emergency contraceptive. There will be no restrictions on where the drug can be sold; it will be up to the manufacturer to propose appropriate venues (6/11).

13 Jun 2013

Green coffee bean dietary supplements does not prevent weight gain in obese mice: Study

A major ingredient in those green coffee bean dietary supplements - often touted as "miracle" weight-loss products - doesn't prevent weight gain in obese laboratory mice fed a high-fat diet when given at higher doses.

13 Jun 2013

Syndrome News and Research

Researchers discover key role of RAP1 gene in obesity

New book explores experiences of polio victims alongside medical, scientific landmarks

Research: Fetal exposure to BPA causes inflammation in fat tissues after birth

Risk assessment scoring system may help identify adults at risk of developing type 2 diabetes

Special type of IVF may increase risk for insulin resistance among children

Women with polycystic ovary syndrome lose more weight when they take two drugs

kisspeptin hormone effectively induces egg maturation during infertility treatment, shows study

New study identifies possible treatment to block deposition of calcium in arterial wall

Drug increases amount of energy burned by fat tissue and promotes weight loss

Researchers identify genetic mutation responsible for MDP Syndrome

Weekend reading: Seeking better health outcomes for homeless people; What becomes of the women denied abortions?

Celgene reports results from placebo-controlled phase II trial in patients with Behçet's disease

CSHL scientists solve the mystery of why some infants born with grave syndrome

Novel antibody biomarkers could significantly improve diagnosis in RA, study shows

Ambry Genetics introduces BRCA1 and BRCA2 analysis

NACC recommendations address established pain therapies and preview potential future advances

Omeros gets regulatory clearance to begin Phase 1 clinical trial of OMS721

Constella® (linaclotide), for the symptomatic treatment of Irritable Bowel Syndrome with Constipation (IBS-C), is now available in Germany, UK and Nordic countries

Viewpoints: Administration 'finally' comes around on Plan B; 'Legal loophole' creates another compounded drug scare

Green coffee bean dietary supplements does not prevent weight gain in obese mice: Study

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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