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Tyk2 enzyme helps regulate obesity through differentiation of brown adipose tissue

Approximately 68 percent of U.S. adults are overweight or obese, according to the National Cancer Institute, which puts them at greater risk for developing cancer, cardiovascular disease, diabetes and a host of other chronic illnesses. But an international team of scientists led by Virginia Commonwealth University Massey Cancer Center researcher Andrew Larner, M.D., Ph.D., has successfully reversed obesity in mice by manipulating the production of an enzyme known as tyrosine-protein kinase-2 (Tyk2).

6 Dec 2012

WHO assists Middle East authorities with coronavirus investigation

The World Health Organization has sent a team to Jordan at the request of the country’s Ministry of Health to help investigate the emergence of a novel coronavirus that resulted in the deaths of two people earlier this year, and to assist with further epidemiologic surveillance.

5 Dec 2012

METACARDIS project to develop and implement personalized treatments for patients with CMDs

Thanks to the support of the European Commission, fourteen partners in six European countries will work together over a five-year period to translate the results obtained with novel CMD diagnosis and treatment methods and pave the way for personalised medicine in CMDs. Researchers and clinicians from the Institute of Cardiometabolism and Nutrition (ICAN) will also be involved in the METACARDIS project.

5 Dec 2012

Study identifies factors that can predict postpartum pelvic girdle pain in working women

A new study of working women has identified factors during pregnancy and postpartum that can predict pain in the joints that comprise the pelvic girdle. While 90 percent of working women in the Netherlands return to work after the birth of their first child, health issues during the postpartum period often require sick leave. Chief among these health issues is pelvic girdle pain (PGP).

5 Dec 2012

Parasympathetic dysfunction underpins Gulf War Syndrome

Gulf War veterans with self-reported symptoms of autonomic dysfunction have objective evidence of underlying damage to central and peripheral cholinergic function, a study shows.

4 Dec 2012

Family history best discriminator of bipolar disorder from depression in young people

A family history of bipolar, psychotic, or substance use disorders best differentiates adolescents and young adults with emerging bipolar disorder from those with unipolar depression, say Australian researchers.

4 Dec 2012

Combined oral contraceptives increase risk of blood clots in women with PCOS

Women with polycystic ovary syndrome (PCOS) who are taking combined oral contraceptives have a 2-fold risk of blood clots compared with women without the disorder who take contraceptives, states a study published in CMAJ (Canadian Medical Association Journal).

4 Dec 2012

Vasculitis and the metabolic syndrome frequently co-exist

The metabolic syndrome is significantly more common in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis than healthy individuals, researchers have found.

3 Dec 2012

Study examines role of inflammation in chronic fatigue syndrome

A new study published in the current issue of Psychotherapy and Psychosomatics has examined the role of inflammation in chronic fatigue syndrome, a disorder that affects many people and does not seem to have an explanation that is likely to yield satisfactory treatment.

1 Dec 2012

Researchers uncover molecular structure of master regulator central to melanoma

With the X-ray vision of DESY's light source DORIS, a research team from Hamburg and Iceland has uncovered the molecular structure of a master regulator central to the most deadly form of skin cancer, melanoma.

1 Dec 2012

New strains of HIV spreading in India, scientists warn

"While India has drastically reduced the spread of HIV over the past decade, new strains of the virus that cause acquired immunodeficiency syndrome (AIDS) are troubling medical scientists in this country," Inter Press Service reports (Devraj, 11/29).

1 Dec 2012

New genetic study defines biology behind brain developmental disorder in children

This study describes how a combination of sequencing and mouse models were used to identify the gene responsible for a brain developmental disorder seen in four patients.

1 Dec 2012

NAP and SAL injection during pregnancy improve memory, learning tasks in offsprings

Mice with a condition that serves as a laboratory model for Down syndrome perform better on memory and learning tasks as adults if they were treated before birth with neuroprotective peptides, according to researchers at the National Institutes of Health.

30 Nov 2012

Special issue of Disease Markers explores ASD genetics and biomarker development

Autism spectrum disorders (ASD) are neurodevelopmental disorders typically characterized by difficulties in social interactions and delayed or abnormal language development. Although ASD reportedly affects 1 in 88 people in the United States, to date there have been no distinctive biomarkers to diagnose the disease.

30 Nov 2012

Sucampo receives supplement approval from FDA for AMITIZA

Sucampo Pharmaceuticals, Inc. today announced that the Company received a supplement approval from the U.S. Food and Drug Administration (FDA) that removes pregnancy "warnings and precautions" and clarifies information regarding the use of AMITIZA (lubiprostone) by pregnant and/or nursing women. In addition, the FDA expanded the labeling text of the Mechanism of Action section in the prescribing information for AMITIZA.

30 Nov 2012

Membrane-proximal external region of HIV could be used to design vaccines

Beatriz Apellaniz, PhD holder of the UPV/EHU-University of the Basque Country, has studied in her PhD thesis HIV regions that could be used to design a vaccine. The researcher has focussed her research on a specific region of the surface protein of the Human Immunodeficiency Virus (HIV), which is responsible for the Autoimmune Deficiency Syndrome (AIDS), one of the diseases with the greatest human morbidity and mortality.

30 Nov 2012

Air quality in cities linked to inflammatory risk in diabetes

Exposure to traffic-related air pollutants is associated with a rapid increase in systemic inflammation in patients with diabetes, report Indian researchers.

30 Nov 2012

UBE3B gene linked to brain development disorder in children

Researchers have defined the gene responsible for a rare developmental disorder in children. The team showed that rare variation in a gene involved in brain development causes the disorder. This is the first time that this gene, UBE3B, has been linked to a disease.

30 Nov 2012

LP-211 compound shows promise against Fragile X syndrome

A potential new therapeutic strategy for treating Fragile X syndrome is detailed in a new report appearing in the current issue of Biological Psychiatry, from researchers led by Dr. Lucia Ciranna at University of Catania in Italy.

29 Nov 2012

AstraZeneca receives FDA approval for Cometriq to treat medullary thyroid cancer

The U.S. Food and Drug Administration today approved Cometriq (cabozantinib) to treat medullary thyroid cancer that has spread to other parts of the body (metastasized).

29 Nov 2012

Syndrome News and Research

Tyk2 enzyme helps regulate obesity through differentiation of brown adipose tissue

WHO assists Middle East authorities with coronavirus investigation

METACARDIS project to develop and implement personalized treatments for patients with CMDs

Study identifies factors that can predict postpartum pelvic girdle pain in working women

Parasympathetic dysfunction underpins Gulf War Syndrome

Family history best discriminator of bipolar disorder from depression in young people

Combined oral contraceptives increase risk of blood clots in women with PCOS

Vasculitis and the metabolic syndrome frequently co-exist

Study examines role of inflammation in chronic fatigue syndrome

Researchers uncover molecular structure of master regulator central to melanoma

New strains of HIV spreading in India, scientists warn

New genetic study defines biology behind brain developmental disorder in children

NAP and SAL injection during pregnancy improve memory, learning tasks in offsprings

Special issue of Disease Markers explores ASD genetics and biomarker development

Sucampo receives supplement approval from FDA for AMITIZA

Membrane-proximal external region of HIV could be used to design vaccines

Air quality in cities linked to inflammatory risk in diabetes

UBE3B gene linked to brain development disorder in children

LP-211 compound shows promise against Fragile X syndrome

AstraZeneca receives FDA approval for Cometriq to treat medullary thyroid cancer

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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