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Study explains the structural basis of higher ACE2 binding affinity of Omicron sub-variants

A team of scientists from China has recently deciphered the structural basis of comparatively higher binding affinity of two Omicron sub-variants, namely B.1.1 and B.2, for human angiotensin-converting enzyme 2 (ACE2).

17 Jun 2022

Effectiveness of a hybrid vaccine against COVID-19 and influenza

Researchers assessed the efficiency of a hybrid vaccine against influenza and COVID-19 viruses.

16 Jun 2022

SARS-CoV-2 damages cilia

Researchers determine whether the interaction between ORF10 and ZYG11B promotes the dissemination of SARS-CoV-2.

15 Jun 2022

Scientists characterize type I IFN response during SARS-CoV-2 infection

In a recent study posted to the bioRxiv* preprint server, Canadian researchers assessed the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on interferon (IFN) response.

15 Jun 2022

The virucidal effects of tea tree oil against FCoVII and HCoV-OC43

Researchers assessed the probable efficacy of tea tree oil (TTO) as a natural disinfectant against SARS-CoV-2 using the human coronavirus OC43 (HCoV-OC43) and feline coronavirus (FCoVII) as surrogate models.

14 Jun 2022

The evolution of the physicochemical mechanism of interaction of the SARS-CoV-2 spike protein with ACE2

Researchers assessed the interactions between SARS-CoV-2 and ACE2.

14 Jun 2022

The potential mechanisms of SARS-CoV-2 to induce DNA damage

Researchers described potential mechanisms of coronaviruses that could lead to DNA damage and the potential link between SARS-CoV-2 activity and such mechanisms.

14 Jun 2022

The role of ARF6 in SARS-CoV-2 endocytosis and infection

Researchers assessed the role of adenoside diphosphate (ADP)-ribosylation factor 6 (ARF6) in SARS-CoV-2 infection.

14 Jun 2022

Molecular snapshots of the productive infectious entry pathway of SARS-CoV-2 into cells

In a recent study posted to the bioRxiv* pre-print server, researchers in the United States demonstrated that the acidic milieu of the nasal cavity is critical for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tropism.

14 Jun 2022

The severity of COVID-19 compared to seasonal influenza

In a recent study under review at the Archives of Virology journal and currently posted to the Research Square* preprint server, investigators in Israel assessed the disparities and similarities between seasonal influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

14 Jun 2022

SARS-CoV-2 BA.4/5 variants escape vaccine and BA.1 infection induced antibodies

In a recent work published in the Cell journal, investigators examined the severe acute respiratory syndrome coronavirus (SARS-CoV-2) Omicron BA.5/4 variants escape from neutralizing antibodies induced by SARS-CoV-2 vaccines and natural infection.

13 Jun 2022

Study reports robust immunity to SARS-CoV-2 including Omicron BA.1 for all three primary vaccines

In a recent study posted to the medRxiv* pre-print server, researchers in the United Kingdom investigated the effect of two Pfizer/BioNTech BNT162b2 vaccine doses or Oxford/AstraZeneca AZ1222 coronavirus disease 2019 (COVID-19) vaccination and a subsequent BNT162b2 booster dose in a cohort of healthcare workers (HCWs) over six to nine months.

10 Jun 2022

Gastrointestinal complications caused by SARS-CoV-2

scientists discuss the gastrointestinal complications associated with COVID-19.

7 Jun 2022

De novo-designed mini-protein against SARS-CoV-2

Researchers characterized truncated forms of LCB1, a de novo-designed mini-protein, against SARS-CoV-2.

7 Jun 2022

Omicron lineage spike proteins use ACE2 receptors more efficiently

A recent study posted to the bioRxiv* preprint server demonstrated various traits, including the entry pathways and sensitivity to vaccination-elicited antibody responses by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants.

7 Jun 2022

Link between COVID-19 severity and microbiome of saliva and nasopharynx

In a recent study posted to the bioRxiv* preprint server, researchers profiled the salivary and nasopharyngeal microbiomes of coronavirus disease 2019 (COVID-19) patients and determined the association between the microbiomes and COVID-19 severity.

6 Jun 2022

Safety and efficacy of SCB-2019 COVID vaccine candidate as a ChAdOx1-S booster

In a recent study posted to the medRxiv* pre-print server, researchers evaluated the immunogenicity of booster doses of alum-adjuvanted SCB-2019 vaccine candidate's three formulations.

6 Jun 2022

The effects of accessory protein mutations and other non-spike mutations on SARS-CoV-2 pathogenesis

Researchers looked into the role played by the accessory proteins using synthetic genomics assembly technology

2 Jun 2022

People with food allergies less likely to become infected with SARS-CoV-2, study finds

A National Institutes of Health-funded study has found that people with food allergies are less likely to become infected with SARS-CoV-2, the virus that causes COVID-19, than people without them. In addition, while previous research identified obesity as a risk factor for severe COVID-19, the new study has identified obesity and high body mass index (BMI) as associated with increased risk for SARS-CoV-2 infection.

1 Jun 2022