Adipose News and Research

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GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders

Senescent cells accumulate in organs during aging, promote tissue dysfunction, and cause numerous aging-related diseases like cancer. The cells arise through a process called "cellular senescence," a permanent cell cycle arrest resulting from multiple stresses.

5 Feb 2021

Immune profiling shows differences in COVID-19 and influenza pathologic pathways

A study conducted at Johns Hopkins University School of Medicine in Baltimore has revealed distinct differences in the immune pathways that are activated by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and those that are activated by influenza.

2 Feb 2021

Pancreatic β cell-derived exosomal miR-29s manipulate glucose homeostasis

In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs).

22 Jan 2021

Omega-3 diet helps Arctic ground squirrels to hibernate a little warmer than normal

By feeding arctic ground squirrels special diets, researchers have found that omega-3 fatty acids, common in flax seed and fish oil, help keep the animals warmer in deep hibernation.

15 Jan 2021

Scientists identify animal model to study human musculoskeletal aging

There are many components to aging, both mental and physical. When it comes to the infrastructure of the human body - the musculoskeletal system that includes muscles, bones, tendons and cartilage - age-associated decline is inevitable, and the rate of that decline increases the older we get.

14 Jan 2021

Vimentin could be a major co-factor that aids SARS-CoV-2 infection

A recent study has found that extracellular vimentin can bind to SARS-CoV-2 spike protein in vitro, and antibodies against vimentin can decrease virus infectivity by up to 80%. This suggests vimentin could aid the virus’s binding to host cells and help in infection.

11 Jan 2021

Scientists discover cell responsible for triggering chronic, low-level inflammation in fat tissue

When fat cells in the body are stuffed with excess fat, the surrounding tissue becomes inflamed. That chronic, low-level inflammation is one of the driving factors behind many of the diseases associated with obesity.

4 Jan 2021

UVA researcher evaluates a new approach to managing type 2 diabetes

A researcher at the University of Virginia School of Medicine is testing what he calls a "radically different" approach to managing type 2 diabetes for those who can't or don't want to lose weight.

18 Dec 2020

Xenon positively affects the properties of coatings deposited on titanium implants

Scientists of Tomsk Polytechnic University jointly with the colleagues from Siberian State Medical University (SSMU) and Immanuel Kant Baltic Federal University studied the properties of calcium phosphate coatings deposited on titanium implants in various inert gases environment.

15 Dec 2020

Study explores link between aging, obesity, and metabolic diseases

Unraveling the links among obesity, aging, telomere lengths and metabolic diseases is the subject of the study published today in Nature Metabolism by a collaborative research team at The University of Texas Health Science Center at Houston (UTHealth).

14 Dec 2020

Study links insulin resistance and ozone exposure to interstitial lung disease

People with pre-diabetes or diabetes who live in ozone-polluted areas may have an increased risk for an irreversible disease with a high mortality rate.

9 Dec 2020

Lipid metabolite in human breast milk can benefit the offspring in early postnatal period

A lipid metabolite called 12,13-diHOME is in human breast milk and appears to be associated with beneficial infant weight gain and body composition in the early postnatal period.

9 Dec 2020

Degenerative process can be reversed by practicing regular aerobic exercise, shows study

Adipose tissue is not just a simple reservoir of energy for periods of food scarcity. It contributes significantly to regulation of the metabolism, releasing various molecules into the bloodstream, including microRNAs that modulate the expression of key genes in different parts of the organism, including the liver, pancreas, and muscles.

8 Dec 2020

Study outlines a new role for pregnancy-associated plasma protein A in gestational diabetes

Laboratory research and analysis of epidemiological data by Silvia Corvera, MD, and Tiffany Moore Simas, MD, MPH, MEd, and colleagues show that low levels of a protein commonly seen in screening tests for chromosomal disorders during the first trimester of pregnancy is associated with adipose tissue remodeling, glucose resistance and gestational diabetes mellitus in pregnant women.

30 Nov 2020

Could the keto diet help prevent or mitigate severe COVID-19?

A new study published in the journal of Translational Medicine reports that the ketogenic diet (KD) may be useful in this area, with its track history of effectual reduction of fat mass, anti-inflammatory and immunomodulatory effects, and consequent improvement of cardiovascular health.

30 Nov 2020

Septic shock and pneumonia triggered by SARS-CoV-2 could be treated by radiation-activated MSCs

This study, published in the journal Cells, is based on others (all of which employed experimental models) previously conducted by researchers at the Biomedical Research Centre of the University of Granada, the ‘López-Neyra’ Institute of Parasitology and Biomedicine, and the ‘Virgen de las Nieves’ University Hospital in Granada

23 Nov 2020

Inflammatory factors that aggravate COVID-19 may come from adipose tissue

There is growing evidence that adipose tissue plays a key role in the aggravation of COVID-19. One of the theories under investigation is that fat cells (adipocytes) act as a reservoir for SARS-CoV-2 and increase viral load in obese or overweight individuals.

20 Nov 2020

Systematic review of epicardial adipose tissue in patients with obstructive sleep apnea

In a new publication from Cardiovascular Innovations and Applications, Bin Liu, Yingrui Li, Janlin Du, Qiang She and Songbai Deng from The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China consider epicardial adipose tissue in patients with obstructive sleep apnea.

20 Nov 2020

Study identifies new factor that offers potential strategy for treating obesity

Obesity is a serious global health problem and a risk factor for diseases such as type II diabetes, heart disease and fatty liver disease.

17 Nov 2020

Combined physical activity and dietary intervention attenuates the rise in insulin resistance in children

A new study from the University of Eastern Finland shows that individualised and family-based physical activity and dietary counselling considerably slows down the development of insulin resistance, which is a precursor of type 2 diabetes, in 6-9-year-old children.

5 Nov 2020