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Deep brain stimulation may improve quality of life in Parkinsons disease

Researchers compare the impact of medication alone or deep brain stimulation of the subthalamic nuclei in quality of life in Parkinson's patients.

22 Jan 2024

Diabetes drugs may help curb alcohol dependence

In social media posts on the community network Reddit, users reported reduced cravings for alcohol when taking drugs intended to treat Type 2 diabetes and obesity.

8 Jan 2024

GLP-1R agonist liraglutide rapidly improves insulin sensitivity in pre-diabetics, independent of weight loss

A new study published in the journal Diabetes demonstrates that a glucagon-like peptide-1 receptor (GLP-1R) agonist, a member of a class of medication used to treat Type 2 diabetes and obesity, can lead to a rapid improvement in insulin sensitivity.

4 Jan 2024

Scientists design non-hallucinogenic psychedelic treatments potentially accelerating research on mental health benefits

Researchers identified 5-hydroxytryptamine 2A (5-HT2A) receptor (5-HT2AR) signaling pathways associated with psychedelic potential.

19 Dec 2023

Only 1 in 18 people with opioid use disorder get effective treatment after overdose

In the week following any hospital visit for an overdose, only 1 in 18 people with opioid use disorder begin a treatment known to be highly effective in reducing illness and deaths, according to new research in CMAJ (Canadian Medical Association Journal).

18 Dec 2023

Simple trick supercharges T cells to fight stubborn solid tumors

Wistar researchers successfully tested a simple intervention that could unlock greater anti-tumor power in therapies that use T cells -; an approach known as "cell-based therapy," which uses specially designed T cells to fight cancer.

13 Dec 2023

Women undergoing chemotherapy may not benefit from common fertility protection drug

A new study from Karolinska Institutet in Sweden has found no evidence that a common drug used to protect the ovaries of women undergoing chemotherapy increases their chances of having children after cancer treatment.

8 Dec 2023

Carrot juice boosts immune response, cuts inflammation, new study reveals

A study in the journal Nutrients by Danish researchers shows that consuming carrot juice, rich in falcarinol and falcarindiol, influences acute inflammatory mediators and innate immune responses in human blood.

4 Dec 2023

MU researchers unveil the immune system's secret weapon against lung cancer

As one of the most insidious diseases in the world, cancer has few treatments that work to eradicate it completely.

4 Dec 2023

Groundbreaking studies indicate Semaglutide and Tirzepatide may reduce alcohol consumption in individuals with obesity

The impact of semaglutide and tirzepatide and glucagon-like peptide-1 receptor agonist medications on alcohol consumption.

1 Dec 2023

Reducing cholesterol esters protects the brain against Alzheimer's-like damage

In Alzheimer's disease and related dementias, cognitive decline is driven by the overaccumulation of a normal brain protein known as tau.

22 Nov 2023

Machine learning uncovers potent immunomodulators for vaccines and immunotherapy

Small molecules called immunomodulators can help create more effective vaccines and stronger immunotherapies to treat cancer.

17 Nov 2023

SELECT trial: Semaglutide reduces cardiovascular events by 20% in overweight or obese patients without diabetes

Findings from a multi-center, international clinical trial reported by a Cleveland Clinic physician show that semaglutide reduced cardiovascular events by 20% in adults with overweight or obesity and established cardiovascular disease who do not have diabetes.

13 Nov 2023

Cannabis and derivatives show promise in reducing weight and waist circumference, with nuanced effects on body fat

The study in the International Journal of Obesity reports that cannabis and its derivatives may influence weight and waist circumference, with different effects on body fat, suggesting potential as a therapeutic aid in obesity management.

8 Nov 2023

Scientists identify progenitor cells that could revolutionize osteoarthritis treatment

Researchers report that osteoarthritis is caused by the loss of Gremlin 1 (Grem1)-lineage chondrogenic progenitor cells.

3 Nov 2023

Does the timing of prenatal exposure to corticosteroids and β2-agonists impact a child's neurodevelopment by age 3?

Researchers investigated the association between the timing of in-utero exposure to β2-agonists and corticosteroids and offspring neurodevelopmental milestones during the initial three years of life.

26 Oct 2023

Researchers discover new way to trigger programmed cell death in cancer cells

A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die.

24 Oct 2023

Ketamine's long-lasting antidepressant effects unveiled in new study

Persistent blocking of NMDAR and burst-type firing by lateral habenula (LHb) neurons may offer a basis for the long-lasting antidepressant effects of ketamine.

22 Oct 2023

Skyrocketing demand for weight-loss drugs prompts calls for informed prescribing

The study reveals a significant increase in the usage of GLP-1 receptor agonists, particularly Ozempic and Trulicity, for weight management and Type 2 diabetes in the U.S. from 2014 to 2022. Amidst rapid growth and shortages, the paper calls for evidence-based decision-making to ensure stable medication supply and effective treatment.

17 Oct 2023

Tirzepatide boosts weight loss in lifestyle intervention patients, but comes with a catch

In a groundbreaking 84-week-long study, researchers found that tirzepatide, a medication initially designed for treating type 2 diabetes, significantly bolstered weight loss in overweight and obese patients already on intensive lifestyle programs. While the drug showed promise in further reducing body weight and improving cardiometabolic factors, mild to moderate gastrointestinal side effects were the most common drawback.

16 Oct 2023