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New method reverses insecticide resistance using CRISPR/Cas9 technology

Insecticides play a central role in efforts to counter global impacts of mosquito-spread malaria and other diseases, which cause an estimated 750,000 deaths each year. These insect-specific chemicals, which cost more than $100 million to develop and bring to market, also are critical to controlling insect-driven damage on crops that poses a challenge to food security.

18 Jan 2022

Quantification of SARS-CoV-2 variants in wastewater samples

In a new study, a team of researchers introduced a novel method to estimate the proportion of different SARS-CoV-2 strains in wastewater samples.

17 Jan 2022

Study finds evidence to strongly implicate OAS1 as an effector gene influencing COVID-19 severity

Researchers demonstrated that this splice variant is likely to be the single nucleotide polymorphism responsible for the association at this locus.

17 Jan 2022

Research provides compelling insights into the complex nature of genomic imprinting in mice

Mammalian offspring inherit two versions, or alleles, of each gene with one allele from each biological parent. However, gene expression is tightly regulated and certain genes undergo the phenomenon of "genomic imprinting", which is where only the allele received by the male or the female parent is expressed.

4 Jan 2022

APOE4 allele gene linked to increased risk of severe COVID-19

A study conducted at the University of Helsinki and the Helsinki University Hospital suggests that the APOE4 allele may also increase cerebral microhemorrhages related to COVID-19 and associate with mental fatigue related to long COVID.

27 Dec 2021

Single-patient pilot study shows the ability of antisense oligonucleotide to suppress mutant ALS gene

Using a short, synthetic chain of chemically modified nucleotides engineered in the RNA Therapeutics Institute at UMass Chan Medical School, Robert H. Brown Jr., DPhil, MD, Jonathan Watts, PhD, and colleagues have shown the ability to suppress mutant forms of an ALS gene known as C9ORF72 in a single-patient pilot study.

24 Dec 2021

Allele-specific RT-qPCR assay to identify SARS-CoV-2 Omicron variant in wastewater

Researchers develop a new allele-specific RT-qPCR to detect the SARS-CoV-2 Omicron variant in wastewater.

23 Dec 2021

Correlation between idiopathic pulmonary fibrosis and COVID-19

A new study investigates the genetic overlap between COVID-19 and idiopathic pulmonary fibrosis to identify possible shared biological mechanisms.

14 Dec 2021

Genetic variations affect and rewire phosphorylation signaling networks in SARS-CoV-2 infection

Researchers study human single nucleotide variants (SNVs) using machine learning to identify amino acid changes that alter kinase-bound sequence motifs.

29 Nov 2021

Two genetic risk variants in Black individuals may exacerbate sepsis and COVID-19 severity

Two genetic risk variants that are carried by nearly 40 percent of Black individuals may exacerbate the severity of both sepsis and COVID-19, a team of researchers from the University of Pennsylvania's Perelman School of Medicine have found.

16 Nov 2021

Scientists document the spread of atrial fibrillation risk gene across continents and over centuries

University of Utah Health scientists have documented the spread of a disease gene across continents and over centuries.

8 Nov 2021

Identification of a candidate effector gene at COVID-19 risk locus

A new study focuses on developing a comprehensive platform to decode the effects of sequence variation identified by GWAS.

8 Nov 2021

Study looks at how lupus genetics intersects with COVID-19

The study “Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19” was recently published on the preprint medRxiv* server.

8 Nov 2021

Highly-sensitive PCR-based method to detect SARS-CoV-2 variants

A team of UK-based scientists has recently developed an allele-specific probe polymerase chain reaction method that can accurately detect different variants/lineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in respiratory samples. Furthermore, the method can detect viral variants even in samples with low viral RNA or degraded viral RNA. The study is currently available on the medRxiv* preprint server.

7 Nov 2021

Experts gain insights into pathomechanisms of dilated cardiomyopathy

Titin is a "titanically large" protein – the largest in the human body – which enables elastic movements of our muscles, including the heart.

6 Nov 2021

Highly-sensitive PCR-based method to detect SARS-CoV-2 variants

A team of scientists has recently developed an allele-specific probe polymerase chain reaction method that can accurately detect different variants/lineages of SARS-CoV-2 in respiratory samples.

4 Nov 2021

Clinical assay validation for SARS-CoV-2 sequencing using Swift Biosciences amplicon panel

The current study used the guidelines of the FDA to validate the one-tube SARS-CoV-2 Swift Normalase Amplicon Panel Version 2.0 from Swift Biosciences.

31 Oct 2021

Genes play a significant role in how the body responds to exercise, finds study

A new study has found that genes play a significant role in how our bodies respond to exercise and has identified a number of specific genes that influence the outcomes of different kinds of physical activity.

15 Oct 2021

Assay for the sensitive and specific identification of SARS-CoV-2 Delta variant

Scientists described a quick and inexpensive method for accurately identifying the Delta variant by applying the double-mismatch allele-specific RT-PCR (DMAS-RT-PCR).

14 Oct 2021

Oxidation-antioxidant imbalance in the blood may be an early indicator of Alzheimer's disease

Research conducted by the Ph.D student Mohamed Raâfet Ben Khedher and the postdoctoral researcher Mohamed Haddad of the Institut national de la recherche scientifique has shown that an oxidation-antioxidant imbalance in the blood is an early indicator of Alzheimer's disease, rather than a consequence.

12 Oct 2021

Allele News and Research

New method reverses insecticide resistance using CRISPR/Cas9 technology

Quantification of SARS-CoV-2 variants in wastewater samples

Study finds evidence to strongly implicate OAS1 as an effector gene influencing COVID-19 severity

Research provides compelling insights into the complex nature of genomic imprinting in mice

APOE4 allele gene linked to increased risk of severe COVID-19

Single-patient pilot study shows the ability of antisense oligonucleotide to suppress mutant ALS gene

Allele-specific RT-qPCR assay to identify SARS-CoV-2 Omicron variant in wastewater

Correlation between idiopathic pulmonary fibrosis and COVID-19

Genetic variations affect and rewire phosphorylation signaling networks in SARS-CoV-2 infection

Two genetic risk variants in Black individuals may exacerbate sepsis and COVID-19 severity

Scientists document the spread of atrial fibrillation risk gene across continents and over centuries

Identification of a candidate effector gene at COVID-19 risk locus

Study looks at how lupus genetics intersects with COVID-19

Highly-sensitive PCR-based method to detect SARS-CoV-2 variants

Experts gain insights into pathomechanisms of dilated cardiomyopathy

Highly-sensitive PCR-based method to detect SARS-CoV-2 variants

Clinical assay validation for SARS-CoV-2 sequencing using Swift Biosciences amplicon panel

Genes play a significant role in how the body responds to exercise, finds study

Assay for the sensitive and specific identification of SARS-CoV-2 Delta variant

Oxidation-antioxidant imbalance in the blood may be an early indicator of Alzheimer's disease

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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